Prognostic impact of albumin-bilirubin score in predicting the long-term survival of distal cholangiocarcinoma after radical surgery.

Background: The Albumin-Bilirubin Score (ALBI) serves as an indicator of nutritional status and is a widely recognized prognostic biomarker in cancer patients. The purpose of this research is to evaluate the association between ALBI and survival outcomes in patients with distal cholangiocarcinoma (dCCA) after radical surgery, and develop a nomogram model based on the ALBI to predict individual survival.

Methods: A total of 177 individuals with dCCA receiving surgery from Jan 2011 to Jan 2022 were enrolled in the research.

Recyclable Dynamic Covalent Networks Derived from Isocyanate Chemistry: The Critical Role of Electronic and Steric Effects in Reversibility.

The dynamic covalent networks (DCNs), featuring dynamic covalent bonds (DCBs) formed through isocyanate-involved chemistry, potentially contributes to a circular economy in polyurea and polyurethane industries, due to the inherent recyclability of DCNs. Over the past decade, remarkable progress has been made in the development of isocyanate-derived DCBs (IdDCBs) for the synthesis of recyclable DCNs, aiming to substitute conventional, non-recyclable materials. Herein, the fundamental aspect of the IdDCB-related chemistries reported to date is investigated, and it is found that their reversibility is governed by electronic and steric effects.

Structure-Property Relationships of Elastomeric Vinylogous Urethane Thermosets and Their Application as Closed-Loop Recyclable Strain Sensors.

Developing closed-loop recyclable thermosets and understanding their structure-property relationships are essential steps in advancing a circular materials economy. Here, we present a vinylogous urethane () thermoset with closed-loop recyclability, synthesized through the reaction of polytetrahydrofuran bisacetoacetate () and tris(2-aminoethyl)amine (). These polymers exhibit high elasticity, with only a 3-9% residual strain observed after cyclic tensile testing at a maximum strain of 100%, depending on the molecular weight of and network cross-link density.

A logistic regression model to predict long-term survival for borderline resectable pancreatic cancer patients with upfront surgery.

Background: The machine learning model, which has been widely applied in prognosis assessment, can comprehensively evaluate patient status for accurate prognosis classification. There still has been a debate about which predictive strategy is better in patients with borderline resectable pancreatic cancer (BRPC). In the present study, we establish a logistic regression model, aiming to predict long-term survival and identify related prognostic factors in patients with BRPC who underwent upfront surgery.

Photo-Cross-linked DNA Structures Greatly Improves Their Serum Nuclease Resistances and Gene Knock-In Efficiencies.

The stabilization and structural integrity of DNA architectures remain significant challenges in their biomedical applications, particularly when inserting functional units into the genome using long single-stranded DNA (lssDNA). To address these challenges, a site-specific photo-cross-linking method is employed. Single-stranded oligonucleotides, containing one or two photosensitive cyanovinylcarbazole nucleoside (K) molecules, are precisely incorporated and cross-linked at the specific sites of ssDNA through base-pairing, followed by rapid UV irradiation at 365 nm.

Direct Monomer Recovery from Ring-Closing Depolymerization of Thermosets.

Recovering monomers from the depolymerization of thermosets presents a significant challenge, which becomes even more daunting if one sets the goal of doing it directly, i.e., without complex chemical separation steps.

Emergent behaviors of two thermodynamically consistent inertial spin models.

We propose two thermodynamically consistent inertial spin models generalizing the inertial spin model for the ensemble of mechanical particles with spin. For the collective dynamics modeling consistent with an entropy principle, we use two modeling ideas based on Hamiltonian formulation and flocking formalism for the coupling of the inertial spin model and temperatures introduced by Ha and Ruggeri [Arch. Ration.

Reaction of β-Ketoester and 1,3-Diol to Access Chemically Recyclable and Mechanically Robust Poly(vinyl alcohol) Thermosets through Incorporation of β-(1,3-dioxane)ester.

The development of mechanically robust, chemically stable, and yet recyclable polymers represents an essential undertaking in the context of advancing a circular economy for plastics. Here, we introduce a novel cleavable β-(1,3-dioxane)ester (DXE) linkage, synthesized through the catalyst-free reaction of β-ketoester and 1,3-diol, to cross-link poly(vinyl alcohol) (PVA) for the formation of high-performance thermosets with inherent chemical recyclability. PVA, modified with β-ketoester groups through the transesterification reaction with excess tert-butyl acetoacetate, undergoes cross-linking reactions with the unmodified 1,3-diols within PVA itself upon thermal treatment.

Revolutionizing cancer treatment: enhancing CAR-T cell therapy with CRISPR/Cas9 gene editing technology.

CAR-T cell therapy, a novel immunotherapy, has made significant breakthroughs in clinical practice, particularly in treating B-cell-associated leukemia and lymphoma. However, it still faces challenges such as poor persistence, limited proliferation capacity, high manufacturing costs, and suboptimal efficacy. CRISPR/Cas system, an efficient and simple method for precise gene editing, offers new possibilities for optimizing CAR-T cells.

Clinical Value of Mean Platelet Volume to Platelet Ratio (MPR) in Distinguishing Mass-Forming Chronic Pancreatitis and Pancreatic Cancer.

Background: Correctly distinguishing mass-forming chronic pancreatitis (MFCP) from pancreatic cancer (PC) is of clinical significance to determine optimal therapy and improve the prognosis of patients. According to research, inflammation status in PC is different from that in MFCP. Mean platelet volume/platelet ratio (MPR) is a platelet-related inflammation index which has been proven to be valuable in the diagnosis and prognosis of various malignant cancers due to the change in mean platelet volume and platelet count under abnormal inflammatory conditions caused by tumors.

Extraction of the Microstructure of Wool Fabrics Based on Structure Tensor.

The trends of "fashionalization", "personalization" and "customization" of wool fabrics have prompted the textile industry to change the original processing design based on the experience of engineers and trial production. In order to adapt to the promotion of intelligent production, the microstructure of wool fabrics is introduced into the finishing process. This article presents an automated method to extract the microstructure from the micro-CT data of woven wool fabrics.

Closed-Loop Recycling of Vinylogous Urethane Vitrimers.

Devising energy-efficient strategies for the depolymerization of plastics and the recovery of their structural components in high yield and purity is key to a circular plastics economy. Here, we report a case study in which we demonstrate that vinylogous urethane (VU) vitrimers synthesized from bis-polyethylene glycol acetoacetates (aPEG) and tris(2-aminoethyl)amine can be degraded by water at moderate temperature with almost quantitative recovery (≈98 %) of aPEG. The rate of depolymerization can be controlled by the temperature, amount of water, molecular weight of aPEG, and composition of the starting material.

Prognostic value of perioperative serum low-density lipoprotein cholesterol level for postoperative prognosis of pancreatic cancer: a retrospective study.

Background: As a common malignant tumour, pancreatic cancer (PC) has the worst clinical outcome. Early evaluation of the postoperative prognosis has certain clinical value. Low-density lipoprotein cholesterol (LDL-c), which is mainly composed of cholesteryl esters, phospholipids, and proteins, plays an important role in transporting cholesterol into peripheral tissues.

Prognostic Value for Perioperative Serum Total Cholesterol Level on Postoperative Long-Term Prognosis of Pancreatic Cancer: A Retrospective Clinical Study.

Cholesterol correlates with occurrence and progression of pancreatic cancer and has predictive value for postoperative prognosis in various cancers. Our study intended to reveal the relationship between perioperative serum total cholesterol (TC) level and postoperative prognosis of pancreatic cancer. We retrospectively analyzed the data of pancreatic cancer patients who underwent surgical treatment at our hospital from January 2015 to December 2021.

Chemical Upcycling of Conventional Polyureas into Dynamic Covalent Poly(aminoketoenamide)s.

The chemical upcycling of polymers is an emerging strategy to transform post-consumer waste into higher-value chemicals and materials. However, on account of the high stability of the chemical bonds that constitute their main chains, the chemical modification of many polymers proves to be difficult. Here, we report a versatile approach for the upcycling of linear and cross-linked polyureas, which are widely used because of their high chemical stability.

Rapid Stress Relaxation, Multistimuli-Responsive Elastomer Based on Dual-Dynamic Covalent Bonds and Aniline Trimer.

Covalent adaptable networks (CANs) are an emerging kind of smart materials in which cross-links are reversible upon some stimuli and then provide malleability and a stimuli-responsive ability to the materials. There is a trend to endow CANs with multistimuli-responsive capabilities and rapid stress relaxation to pursue more advanced applications. To integrate these two features into one material, here, dual-dynamic covalent bonds (imines and boronic esters) and aniline trimer (ACAT) were incorporated into the styrene butadiene elastomer as dynamic cross-links.

Integrating Boronic Esters and Anthracene into Covalent Adaptable Networks toward Stimuli-Responsive Elastomers.

Stimuli-responsive polymer materials have a promising potential application in many areas. However, integrating multi-stimuli into one elastomer is still a challenge. Here, we utilized boronic esters and anthracene to prepare a cross-linked poly(styrene-butadiene-styrene) (SBS) which was endowed with responsiveness to three stimuli (light, heat, and alcohols).

Aminoesterenamide Achieved by Three-Component Reaction Heading toward Tailoring Covalent Adaptable Network with Great Freedom.

Covalent adaptable networks (CANs) have recently received extensive interests due to their reprocessability and repairability. Rethinking the libraries of the published CANs, most of them are fabricated by one/two-component reactions and few cases utilize multi-component reactions to construct CANs while multi-component reactions are conductive to tailoring the properties of polymers due to their structural designability and flexible choice of raw materials. A novel kind of dynamic covalent bond named aminoesterenamide is presented through three-component reaction between acetoacetyl, amine and isocyanate.

A high-resolution Asia-Pacific regional coupled prediction system with dynamically downscaling coupled data assimilation.

A regional coupled prediction system for the Asia-Pacific (AP-RCP) (38°E-180°, 20°S-60°N) area has been established. The AP-RCP system consists of WRF-ROMS (Weather Research and Forecast, and Regional Ocean Model System) coupled models combined with local observational information through dynamically downscaling coupled data assimilation (CDA). The system generates 18-day forecasts for the atmosphere and ocean environment on a daily quasi-operational schedule at Pilot National Laboratory for Marine Science and Technology (Qingdao) (QNLM), consisting of 2 different-resolution coupled models: 27 km WRF coupled with 9 km ROMS, 9 km WRF coupled with 3 km ROMS, while a version of 3 km WRF coupled with 3 km ROMS is in a test mode.

Restrains Apatinib Resistance in Human Gastric Cancer Cells Via Downregulating .

Repeated administration of apatinib has resulted in serious drug resistance in gastric cancer (GC). Previous studies showed that had a low expression in GC, and homeobox gene C10 (), a carcinogenic gene, was highly expressed in GC, while the molecular mechanism of involved in apatinib resistance in GC cells is still unclear. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression levels of and in GC tissues or cell lines.

Severity and incidence of complications assessed by the Clavien-Dindo classification following robotic and laparoscopic gastrectomy for advanced gastric cancer: a retrospective and propensity score-matched study.

Background: Robot-assisted gastrectomy (RAG) has been increasingly used for the treatment of advanced gastric cancer (AGC), and many advantages over laparoscopy-assisted gastrectomy (LAG) have been reported. However, its postgastrectomy complications still under investigation and the results remain controversial. This study aimed to objectively assess the incidence and severity of complications following RAG vs.