Preliminary safety risk assessment of parabens in children's cosmetics sold in China.

Since adverse health outcomes of parabens added in children's cosmetics have been reported, it is important to investigate preliminary risk characteristic assessment of parabens preservatives in children's cosmetics. This study aimed to calculate exposure parameters using a combination experimental data and an exposure assessment tool to make safety assessment for parabens in children's cosmetics. The paraben concentration of different formulation types of 63 products of children's cosmetic products were measured by High Performance Liquid Chromatography.

Chinese Named Entity Recognition for Dairy Cow Diseases by Fusion of Multi-Semantic Features Using Self-Attention-Based Deep Learning.

Named entity recognition (NER) is the basic task of constructing a high-quality knowledge graph, which can provide reliable knowledge in the auxiliary diagnosis of dairy cow disease, thus alleviating problems of missed diagnosis and misdiagnosis due to the lack of professional veterinarians in China. Targeting the characteristics of the Chinese dairy cow diseases corpus, we propose an ensemble Chinese NER model incorporating character-level, pinyin-level, glyph-level, and lexical-level features of Chinese characters. These multi-level features were concatenated and fed into the bidirectional long short-term memory (Bi-LSTM) network based on the multi-head self-attention mechanism to learn long-distance dependencies while focusing on important features.

Quantification of Losartan Potassium Polymorphs Using Powder X-Ray Diffraction.

Background: Losartan potassium, a common antihypertensive drug on the market, has multiple polymorphs, of which form I is used as a pharmaceutical crystal form. Form I can be partially converted to form III under some circumstances. The quantification of losartan potassium polymorphs is important to control the quality of pharmaceuticals.

Separation and characterization of forced degradation products in homoharringtonine injection by UHPLC-Q-TOF-MS.

A rapid ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed for separation and characterization of the degradation products in HHT injection. Chromatographic separation was achieved on a ZORBAX Eclipse XDB-C18 HD column (2.1 × 100 mm, 1.

[Protective effect of Dendrobium candidum on isoproterenol induced cardiac hypertrophy in rats].

To study the effect and mechanism of Dendrobium candidum on isoproterenol-induced myocardial hypertrophy in rats, 60 healthy SD rats(30 males and 30 females) were randomly divided into 5 groups(12 in each group): normal group, model group, three D. candidum preventive administration groups(0.09, 0.

[Synthesis and anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives].

Aim: To study the anti-inflammatory activity of N-(4-arylamidophenyl) methanesulfonamide derivatives.

Methods: The target compounds were synthesized from p-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice.

Results: Eleven compounds were obtained and confirmed by IR, 1HNMR and MS.