[Analysis of Reproductive Tract Microecological Changes During the Frozen-Thawed Embryo Transfer Cycle and Clinical Pregnancy Outcomes].

Objective: This study aims to analyze the relationship between reproductive tract microecological changes, metabolic differences, and pregnancy outcomes at different time points in the frozen-thawed embryo transfer cycle while patients are undergoing hormone replacement therapy, which will be a breakthrough point for improving outcomes.

Methods: A total of 20 women undergoing frozen-thawed single blastocyst transfer for the first time at the Reproductive Medicine Center of Fujian Maternal and Child Health Hospital between July 2022 and January 2023 were recruited for this study. Their vaginal and cervical secretions were collected for 16S rRNA sequencing and non-targeted metabolomics analysis on days 2-5 of menstruation, day 7 after estrogen replacement therapy started, the day when progesterone was added, and the day of transplantation.

Horizontal and Vertical Transmission of a Mycovirus Closely Related to the Partitivirus RhsV717 That Confers Hypovirulence in .

Rhizoctonia solani virus717 (RhsV717) was isolated from the () AG-2 strain Rhs717. This study isolated a virus designated as Rhizoctonia solani partitivirus BS-5 (RsPV-BS5) from the AG-3 strain BS-5, the causal agent of tobacco target spot disease. The virus was identified as a strain of RhsV717.

Functional connectivity changes in infants with varying degrees of unilateral hearing loss.

It has been proved that unilateral hearing loss (UHL) can cause functional connectivity alterations in adults. However, the mechanism of the human brain coping with the challenge of unilateral hearing deprivation at very early developmental phases remains poorly understood. Here, we performed a resting-state functional near-infrared spectroscopy (fNIRS) study on 3- to 10-month-old infants with varying degrees of unilateral hearing loss to investigate the effect of unilateral auditory deprivation in infants.

Exosomes: Mediators in microenvironment of colorectal cancer.

Tumor microenvironment, the soil where tumor thrives, plays a critical role in the development and progression of colorectal cancer (CRC). Various cell signaling molecules in the environment promote tumor angiogenesis, immune tolerance and facilitate immune escape. Exosomes, as messengers between tumor and host cells, are considered key mediators involved in the tumor-accelerating environment.

Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells.

Background And Aims: Oxidative stress and abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) influence atherosclerosis formation and development. Oxidative stress significantly influences the abnormal proliferation and migration of VSMCs, and nuclear factor erythroid 2-related factor 2 (Nrf2) is a major antioxidant factor. However, the precise function of Nrf2 in the regulation of abnormal proliferation and migration of VSMCs and atherosclerosis is unclear.

Perioperative Exercise Intention and Influencing Factors: A Multi-Centered Cross-Sectional Study.

This study aimed to evaluate the level and factors affecting the perioperative exercise intention in China. This study was a cross-sectional survey in Southwest China. Four hundred and ninety nine participants were randomly sampled in eight medical centers from November 23, 2020 to November 27, 2020.

[Value of 18F-FDG PET imaging in diagnosing tumor residue of intracranial glioma after surgery and radiotherapy].

Background & Objective: It is difficult to diagnose tumor residue by CT/MRI after treatment. The application of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) to determine the suspected tumor residue after treatment has become a hot target in the study of radiotherapy. This study was designed to discuss the clinical value of (18)-FDG PET imaging in post-operative and post-radiotherapeutic intracranial glioma.

[Detection of residue of nasopharyngeal carcinoma with FDG PET].

Background And Objective: The use of F-18-fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) in detection of suspected residue of malignant tumor after treatment has become one of the most important targets of study in radiotherapy. This study was designed to evaluate FDG PET in detection of suspected residue of nasopharyngeal carcinoma (NPC) after treatment, in comparison with CT imaging.

Methods: Twenty-five patients with clinically suspected residue of NPC did FDG PET Scanning, 23 of them also examine with CT imaging.