Wind vector retrieval algorithm for a coherent Doppler lidar based on KNN-COOKS.

The wind vector retrieval from a coherent Doppler lidar system in the plan position indicator (PPI) scanning mode often suffers from high inversion errors in horizontal wind speed and direction at far-range gates due to "erroneous" radial wind speed. To address this, we propose a weighted sine wave fitting algorithm that combines K-nearest neighbors and Cook's distance (KNN-COOKS). Numerical simulation experiments show KNN-COOKS achieves higher accuracy than direct sine wave fitting (DSWF) and adaptive iterative reweighted sine wave fitting (AIR) and performs comparably to filtered sinusoidal wave fitting (FSWF).

Analysis of temperature detection performance of vibration-rotation Raman lidar based on different calibration functions.

Rotational Raman (RR) lidar is widely employed for atmospheric temperature detection, but its detection capability is constrained in cloudy or hazy conditions due to the interference of elastic scattering leakage to the pure RR channels. To address this limitation, a vibrational-rotational Raman (VR) temperature measurement technique has been proposed and validated. This study compares the performance of VR and RR techniques through simulations and observational experiments.

The Association of Electrical Delay on Hemodynamic Response With Cardiac Resynchronization Therapy.

Background: The effect of electrical delay at the left ventricular (LV) pacing site on acute hemodynamic response with cardiac resynchronization therapy (CRT) has been investigated only in small observational studies.

Objectives: This study evaluates the impact of electrical delay, as assessed by interventricular (right ventricular-LV]) interval, on the acute hemodynamic response to CRT in a large, diverse multicenter cohort.

Methods: A total of 144 patients in 3 prospective studies, the PATH-CHF (Pacing Therapies in Congestive Heart Failure) I and II and the CRTAVO (CRT Optimization Algorithm Validation Study), were pooled and analyzed.

Phosphoenolpyruvate and Related Metabolic Pathways Contribute to the Regulation of Plant Growth and Development.

Phosphoenolpyruvate (PEP) plays a key role in the development of plants and exists in a wide variety of species. Research on the metabolic activities of PEP in plants has received increasing attention. PEP regulates multiple processes in plant growth and development.

Advancing EGFR mutation subtypes prediction in NSCLC by combining 3D pretrained ConvNeXt, radiomics, and clinical features.

Purpose: The aim of this study was to develop a novel approach for predicting the expression status of Epidermal Growth Factor Receptor (EGFR) and its subtypes in patients with Non-Small Cell Lung Cancer (NSCLC) using a Three-Dimensional Convolutional Neural Network (3D-CNN) ConvNeXt, radiomics features and clinical features.

Materials And Methods: A total of 732 NSCLC patients with available CT imaging and EGFR expression data were included in this retrospective study. The region of interest (ROI) was manually segmented, and clinicopathological features were collected.

Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma.

This research explores the potential of multimodal fusion for the differential diagnosis of early-stage lung adenocarcinoma (LUAD) (tumor sizes < 2 cm). It combines liquid biopsy biomarkers, specifically extracellular vesicle long RNA (evlRNA) and the computed tomography (CT) attributes. The fusion model achieves an impressive area under receiver operating characteristic curve (AUC) of 91.

Modulates Starch Biosynthesis at High Temperatures in Rice.

High temperatures accelerate the accumulation of storage material in seeds, often leading to defects in grain filling. However, the mechanisms regulating grain filling at high temperatures remain unknown. Here, we want to explore the quality factors influenced by the environment and have identified a gene, , a heat-stress-responsive gene in rice grain filling.

Downregulation of miR-4284 can Inhibit the Apoptosis of Human Arterial Smooth Muscle Cells (HASMCs) in Arteriosclerosis Obliterans (ASO).

Introduction: The disease arteriosclerosis obliterans (ASO) affects the lower extremities. ASO's mechanism involves the proliferation and migration of vascular smooth muscle cells (VSMCs). The miR-4284 is involved in several biological processes of the cardiovascular system, including VSMC proliferation, migration, and death.

China lung cancer screening (CLUS) version 2.0 with new techniques implemented: Artificial intelligence, circulating molecular biomarkers and autofluorescence bronchoscopy.

Objective: The present study, CLUS version 2.0, was conducted to evaluate the performance of new techniques in improving the implementation of lung cancer screening and to validate the efficacy of LDCT in reducing lung cancer-specific mortality in a high-risk Chinese population.

Methods: From July 2018 to February 2019, high-risk participants from six screening centers in Shanghai were enrolled in our study.

The impact of chronotropic incompetence on atrioventricular conduction times in heart failure patients.

Background: Intrinsic atrioventricular (AV) conduction is used to optimize AV intervals with cardiac resynchronization therapy (CRT) in most device algorithms. Atrial pacing and heart rate affect conduction times, but little is known regarding differeces among chronotropic incompetent(CI) and competent(CC) patients to guide programming.

Methods: RAVE was a multicenter prospective trial of CRT patients.

Comparative transcriptome analysis of the cold resistance of the sterile rice line 33S.

Rice (Oryza sativa L.) is one of the most important species for food production worldwide. Low temperature is a major abiotic factor that affects rice germination and reproduction.

Real-Time Life-Cycle Monitoring of Composite Structures Using Piezoelectric-Fiber Hybrid Sensor Network.

In this paper, an in situ piezoelectric-fiber hybrid sensor network was developed to monitor the life-cycle of carbon fiber-reinforced plastics (CFRPs), from the manufacturing phase to the life in service. The piezoelectric lead-zirconate titanate (PZT) sensors were inserted inside the composite structures during the manufacturing process to monitor important curing parameters, including the storage modulus of resin and the progress of the reaction (POR). The strain that is related to the storage modulus and the state of resin was measured by embedded fiber Bragg grating (FBG) sensors, and the gelation moment identified by the FBG sensors was very close to those determined by dynamic mechanical analysis (DMA) and POR.

Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice.

Two type II-C Cas9 orthologs (Nm1Cas9 and Nm2Cas9) were recently identified from Neisseria meningitidis and have been extensively used in mammalian cells, but whether these NmCas9 orthologs or other type II-C Cas9 proteins can mediate genome editing in plants remains unclear. In this study, we developed and optimized targeted mutagenesis systems from NmCas9s for plants. Efficient genome editing at the target with N GATT and N CC protospacer adjacent motifs (PAMs) was achieved with Nm1Cas9 and Nm2Cas9 respectively.

Immunogenicity and safety of sabin-strain based inactivated poliovirus vaccine replacing salk-strain based inactivated poliovirus vaccine: An innovative application of different strain-IPVs replacement.

Background: A domestic Sabin strain-based inactivated poliovirus vaccine (Sabin IPV) was approved by China Food and Drug Administration in 2017 as a replacement for the Salk strain-based inactivated poliovirus vaccine (Salk IPV) that has been in use in China for over 10 years. The present post-marketing trial was implemented in China to assess the immunogenicity and safety of replacing the Salk IPV with the Sabin IPV in the last two immunizations of the standard three-dose schedule.

Methods: We conducted a randomized, controlled clinical trial with two groups that received three doses of IPVs at the age of 2, 3, and 4 months: the Salk-Sabin-Sabin group and the Salk-Salk-Salk group.

Embedded FBG Sensor Based Impact Identification of CFRP Using Ensemble Learning.

Impact brings great threat to the composite structures that are extensively used in an aircraft. Therefore, it is necessary to develop an accurate and reliable impact monitoring method. In this paper, fiber Bragg grating (FBG) sensors are embedded in unidirectional carbon fiber reinforced plastics (CFRPs) during the manufacturing process to monitor the strain that is related to the elastic modulus and the state of resin.

The effect of posture, exercise, and atrial pacing on atrioventricular conduction in systolic heart failure.

Background: Optimization of atrioventricular (AV) intervals for cardiac resynchronization therapy (CRT) programming is typically performed in supine patients at rest, which may not reflect AV timing in other conditions.

Objective: To evaluate the effects of posture, exercise, and atrial pacing on intrinsic AV intervals in patients with CRT devices.

Methods: Rate-dependent A-V delay by exercise was a multicenter, prospective trial of patients in sinus rhythm following CRT implantation.

WGCNA Analysis of Salt-Responsive Core Transcriptome Identifies Novel Hub Genes in Rice.

Rice, being a major staple food crop and sensitive to salinity conditions, bears heavy yield losses due to saline soil. Although some salt responsive genes have been identified in rice, their applications in developing salt tolerant cultivars have resulted in limited achievements. Herein, we used bioinformatic approaches to perform a meta-analysis of three transcriptome datasets from salinity and control conditions in order to reveal novel genes and the molecular pathways underlying rice response to salt.

Effect of Interventricular Electrical Delay on Atrioventricular Optimization for Cardiac Resynchronization Therapy.

Background: Routine atrioventricular optimization (AVO) has not been shown to improve outcomes with cardiac resynchronization therapy (CRT). However, more recently subgroup analyses of multicenter CRT trials have identified electrocardiographic or lead positions associated with benefit from AVO. Therefore, the purpose of this analysis was to evaluate whether interventricular electrical delay modifies the impact of AVO on reverse remodeling with CRT.

Acute biventricular hemodynamic effects of cardiac resynchronization therapy in right bundle branch block.

Background: Controversy remains regarding the use of cardiac resynchronization therapy (CRT) in patients with heart failure with right bundle branch block (RBBB) and reduced left ventricular (LV) ejection fraction. Moreover, little is known about acute hemodynamic changes with CRT in this subgroup as compared with patients with left bundle branch block (LBBB).

Objective: The purpose of this study was to evaluate the acute biventricular hemodynamic response of CRT and other pacing configurations, including the effects of atrioventricular (AV) delay and atrial pacing, to understand the effects of CRT in RBBB.

Performance analysis of an optical self-interference cancellation system with a directly modulated laser-based demonstration.

In this paper, two main performance indices of the optical self-interference cancellation (OSIC) system are theoretically analyzed: cancellation bandwidth and depth. Delay deviation is investigated to be the determining factor of cancellation bandwidth, based on which the bandwidth advantage of the OSIC system over electrical schemes is also proven theoretically. Cancellation depth in the narrowband is mostly influenced by attenuation and delay-adjusting deviation, while in the broadband case, the performance is mostly limited by frequency-dependent amplitude and phase mismatch.

The role of interventricular conduction delay to predict clinical response with cardiac resynchronization therapy.

Background: Pacing at sites with late electrical activation or greater interventricular delay is associated with improvement in measures of cardiac resynchronization therapy (CRT) response, primarily reverse remodeling. However, little is known about whether such lead positions improve heart failure (HF) clinical outcomes.

Objective: The purpose of this study was to assess the association between interventricular electrical delay and HF clinical outcomes.

Experimental study of wideband in-band full-duplex communication based on optical self-interference cancellation.

In this paper, we experimentally demonstrate and study a wideband in-band full-duplex (IBFD) wireless communication system based on optical self-interference cancellation (SIC). The optical SIC performances based on antennas for broadband IBFD are firstly evaluated within high frequency bands (> 10GHz). In this system, two electro-absorption-modulated lasers (EMLs) and a balanced photo-detector (BPD) are employed to remove the wideband self-interference within received wireless signal.

Longer Left Ventricular Electric Delay Reduces Mitral Regurgitation After Cardiac Resynchronization Therapy: Mechanistic Insights From the SMART-AV Study (SmartDelay Determined AV Optimization: A Comparison to Other AV Delay Methods Used in Cardiac Resynchronization Therapy).

Background: Mitral regurgitation (MR) is associated with worse survival in those undergoing cardiac resynchronization therapy (CRT). Left ventricular (LV) lead position in CRT may ameliorate mechanisms of MR. We examine the association between a longer LV electric delay (QLV) at the LV stimulation site and MR reduction after CRT.