Bioinspired Iontronic Pressure Sensor with Ultrawide Range and High Sensitivity.

The trade-off between sensitivity and detection range has limited the performance of flexible pressure sensors, hindering their deployment in advanced human-machine interfaces and precision healthcare monitoring. Inspired by the ion-mediated electrogenesis of electric eels, we report a bioinspired iontronic pressure sensor (IPS) that overcomes this bottleneck by coupling MXene-functionalized electrodes with a hierarchical silica aerogel/ionic liquid (ILA) dielectric. This architecture enables pressure-driven, reversible ion migration within the porous dielectric and enhances electrical double-layer (EDL) formation at the electrode-dielectric interface.

Analysis of Transdermal Distribution and Blood Components in Guinea Pigs Following the Application of Bai Jie Zi San Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Ultra-High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry.

Introduction: Bai Jie Zi San (BJZS) is a traditional Chinese herbal formula commonly used in acupoint sticking therapy, extensively used in clinical practice for the prevention and treatment of asthma. It has a wide application not only in China but also across various East Asian countries.

Objective: This study aimed to analyze the transdermal distribution and blood components in guinea pigs following the application of BJZS.

Targeting IL13Rα2 in melanoma with a bispecific T-cell engager: expression profiling and preclinical evaluation.

Background: Melanoma is a highly aggressive skin cancer, especially in advanced stages. While current treatments such as targeted therapies and immunotherapies have made significant progress, challenges like drug resistance and limited effectiveness in some patients persist. Therefore, ongoing development of novel therapies, particularly for late-stage melanoma, is crucial.

Early-life antibiotic dysbiosis impairs microbial tryptophan- nicotinic acid metabolism exacerbating food allergy in adulthood.

Food allergy (FA) pathogenesis links to intestinal dysbiosis, with antibiotic exposure a suspected risk factor, yet mechanisms are unclear. Our study shows early life (EL) antibiotic exposure in mice heightens susceptibility to OVA - induced allergic intestinal inflammation. EL - antibiotics cause intestinal dysbiosis, like Clostridia and Muribaculaceae depletion and Sutterellaceae enrichment, disrupting tryptophan metabolism and reducing nicotinic acid (NA).

Carbon dot-mediated synthesis of NaYF:Yb,Er@carbon dot composites with enhanced upconversion luminescence for temperature sensing.

Upconversion (UC) nanocrystals and carbon dots (CDs) have emerged as significant subjects of research interest across various fields, including biomedicine, fluorescence sensing, and anti-counterfeiting. This study presents a novel method for preparing NaYF:Yb,Er@CDs composites through the cubic-to-hexagonal phase transformation of NaYF mediated by CDs. The formation of these composites was successfully confirmed through morphological and structural analyses.

Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas.

Purpose: To identify the specific intratumoral and microenvironmental heterogeneity of acral melanoma (AM) and mucosal melanoma (MM), we aimed to delineate their distinct cellular compositions, evolutionary trajectories, and subtype-specific therapeutic strategies.

Experimental Design: Single-cell transcriptomic and genomic landscapes were analyzed across 42 melanoma (28 AM, 11 MM, and 3 nonacral cutaneous melanoma) samples, supplemented by in vitro and in vivo validation. Tumor and stromal cells were profiled using single-cell RNA sequencing, whole-exome sequencing, and functional assays, including transwell migration, co-culture systems, and xenograft models.

Prognostic value of neurotensin in experimental terminal ileitis.

BackgroundTerminal ileitis (TI) is an inflammatory condition of the distal portion of the ileum.ObjectiveTo investigate the changes and significance of neurotensin (NT) in the course of experimental terminal ileitis (ETI).MethodsA total of 90 Sprague Dawley (SD) rats were randomly divided into the control, model, and suture groups (30 rats in each group).

Iron-Supported Asymmetric Iontronic Pressure Sensors with High Sensitivity and Extended Linearity.

Iontronic pressure sensors (IPSs) are emerging as promising candidates for integration into wearable electronics and healthcare monitoring systems due to their high sensitivity and low power consumption. However, achieving high sensitivity across a broad linear pressure range remains a significant challenge. This study presents a novel IPS device with an asymmetric sandwich structure, which includes a three-dimensional electrode made of nickel manganese oxide/carbon nanotubes (NMO/CNT) and an embedded iron needles ionic dielectric layer.

Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells.

Small extracellular vesicles (sEVs) are nanosized vesicles. Death receptor 5 (DR5) mediates extrinsic apoptosis. We engineer DR5 agonistic single-chain variable fragment (scFv) expression on the surface of sEVs derived from natural killer cells.

Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization.

Tumor-associated macrophages (TAMs) play dual roles (both pro- and antitumor) in tumor progression. TAMs induce programmed death ligand-1 (PD-L1) expression in cancer cells. However, the regulatory effects of PD-L1 in melanoma cells on TAM phenotypical switching remain underexplored.

A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade Therapies.

Unlabelled: While a subset of patients with metastatic melanoma achieves durable responses to immune checkpoint blockade (ICB) therapies, the majority ultimately exhibit either innate or acquired resistance to these treatments. However, the molecular mechanisms underlying resistance to ICB therapies remain elusive and are warranted to elucidate. Here, we comprehensively investigated the tumor and tumor immune microenvironment (TIME) of paired pre- and post-treatment tumor specimens from metastatic melanoma patients who were primary or secondary resistance to anti-CTLA-4 and/or anti-PD-1/PD-L1 therapies.

Seismic response of mountain tunnel induced by fault slip.

With the rapid development of Chinese transportation networks, such as the Sichuan-Tibet railway, numerous tunnels are under construction or planned in mountainous regions. Some of these tunnels must traverse or be situated near active fault zones, which could suffer damage from fault slip. In this study, the seismic response of a mountain tunnel subjected to coseismic faulting was analyzed using a fault-structure system in a two-step process.

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis.

Patient-derived xenografts (PDX) model human intra- and intertumoral heterogeneity in the context of the intact tissue of immunocompromised mice. Histologic imaging via hematoxylin and eosin (H&E) staining is routinely performed on PDX samples, which could be harnessed for computational analysis. Prior studies of large clinical H&E image repositories have shown that deep learning analysis can identify intercellular and morphologic signals correlated with disease phenotype and therapeutic response.

Changes in the state of matter of KCIO to improve thermal and combustion properties of Al/MoO nanothermite.

To improve the thermal and combustion properties of nanothermites, a design theory of changing the state of matter and structural state of the reactants during reaction was proposed. The Al/MoO/KClO (Kp) nanothermite was prepared and the Al/MoO nanothermite was used as a control. SEM and XRD were used to characterize the nanothermites; DSC was used to test thermal properties; and constant volume and open combustion tests were performed to examine their combustion performance.

Multivariate Analysis Compares and Evaluates Heat Tolerance of Potato Germplasm.

High temperature is the most important environmental factor limiting potato ( L.) yield. The tuber yield has been used to evaluate the heat tolerance of some potato cultivars, but potato yield was closely correlated with the maturation period.

Rose long noncoding RNA lncWD83 promotes flowering by modulating ubiquitination of the floral repressor RcMYC2L.

Long noncoding RNAs (lncRNAs) play important roles in various signaling pathways in vascular plants. However, the crosstalk between lncRNAs and E3 ubiquitin ligases has been barely reported. In this study, we demonstrate that the lncRNA lncWD83 from rose (Rosa chinensis) 'Old blush' activates flowering by modulating the ubiquitination of the floral repressor MYC2 LIKE (RcMYC2L).

The intragenic cis-elements mediate temperature response of RrKSN.

Gene regulation via intragenic sequences is becoming more recognized in many eukaryotes. However, the intragenic sequences mediated gene expressions in response to environmental stimuli have been largely uncharacterized. Here, we showed that the first intron of RrKSN from the Rosa rugosa cultivar 'Purple branch' had a positive effect on RrKSN expression, and the effect depends on its position and orientation.

Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells.

Even among genetically identical cancer cells, resistance to therapy frequently emerges from a small subset of those cells. Molecular differences in rare individual cells in the initial population enable certain cells to become resistant to therapy; however, comparatively little is known about the variability in the resistance outcomes. Here we develop and apply FateMap, a framework that combines DNA barcoding with single-cell RNA sequencing, to reveal the fates of hundreds of thousands of clones exposed to anti-cancer therapies.

Research on the Measurement Technology of Rotational Inertia of Rigid Body Based on the Principles of Monocular Vision and Torsion Pendulum.

Damping is an important factor contributing to errors in the measurement of rotational inertia using the torsion pendulum method. Identifying the system damping allows for minimizing the measurement errors of rotational inertia, and accurate continuous sampling of torsional vibration angular displacement is the key to realizing system damping identification. To address this issue, this paper proposes a novel method for measuring the rotational inertia of rigid bodies based on monocular vision and the torsion pendulum method.

Melanoma-intrinsic NR2F6 activity regulates antitumor immunity.

Nuclear receptors (NRs) are implicated in the regulation of tumors and immune cells. We identify a tumor-intrinsic function of the orphan NR, NR2F6, regulating antitumor immunity. NR2F6 was selected from 48 candidate NRs based on an expression pattern in melanoma patient specimens (i.

Electroacupuncture alleviates mechanical allodynia and anxiety-like behaviors induced by chronic neuropathic pain via regulating rostral anterior cingulate cortex-dorsal raphe nucleus neural circuit.

Aims: Epidemiological studies in patients with neuropathic pain have demonstrated a strong association between neuropathic pain and psychiatric conditions such as anxiety. Preclinical and clinical work has demonstrated that electroacupuncture (EA) effectively alleviates anxiety-like behaviors induced by chronic neuropathic pain. In this study, a potential neural circuitry underlying the therapeutic action of EA was investigated.

Optimization of extraction process of 15 bioactive compounds from Qing Fei Yi Huo tablets using response surface methodology.

Qing Fei Yi Huo tablets (QFYHT) can relieve the clinical symptoms of acute bronchitis, and is widely prescribed in China. However, the quality standard of QFTHT lacks quantitative assessment. Therefore, it is crucial to develop an effective method for the extraction and analyses of its bioactive components.