Supraclavicular oblique incision sternocleidomastoid intermuscular approach versus traditional low collar incision linea Alba Cervicalis Approach in thyroid lobectomy (LATERAL study): the protocol for a multicenter prospective non-randomized controlled study.

Background: A Chinese multicenter prospective cohort study of supraclavicular oblique incision sternocleidomastoid intermuscular approach (SOI-SMIA) versus traditional low collar incision linea alba cervicalis approach (TCLI-LACA) in thyroid lobectomy for papillary thyroid carcinoma (LATERAL study) has been initiated. The aim is to compare surgical approach-related outcomes in thyroid lobectomy. We here outline the detailed protocol for this study.

Simplified Chinese lexicon project: A lexical decision database with 8105 characters and 4864 pseudocharacters.

This paper presents the Simplified Chinese Lexicon Project (SCLP), which collects lexical decision data for all 8105 characters in the List of Commonly Used Standard Chinese Characters and for 4864 pseudocharacters, which were generated using a novel method that leveraged the hierarchical nature of Chinese characters. We compared the collected data to existing megastudies on Chinese characters, and found that the newly collected data performed similarly in terms of reliability. The comprehensive coverage of simplified Chinese characters in the present study added to the existing studies by allowing for a more fine-grained investigation of the effects of a variety of character attributes on visual processing.

Exosomes derived from bone marrow-derived mesenchymal stem cells of exercise-trained mice improve wound healing by inhibiting macrophage M1 polarization.

Background: Engaging in appropriate exercise is advantageous for our well-being. We investigated whether exercise could affect the paracrine function of BMSCs and whether exosomes derived from treadmill exercise-trained mouse (Exo-tread) BMSCs could engender more pronounced effects on wound healing.

Methods: First, the effects of treadmill exercise on mouse BMSCs biological functions, exosomes secretion quantity, and identification were assessed.

MiR-451a-Enriched Small Extracellular Vesicles Derived from Mg-Activated DPSCs Induce Vascularized Bone Regeneration through the AKT/eNOS/NO Axis.

Blood vessel formation is a necessary part of bone tissue regeneration. MSCs-sEVs play a vital role in the in vivo bone regeneration strategy. However, natural MSCs-sEVs suffer from limited blood vessel formation potency, which makes it difficult to induce vascularized bone regeneration.

Association between cognitive function and Cre/BW in middle-aged and older Chinese adults: evidence from the CHARLS.

Background: Cre/BW has been widely validated as a reliable biomarker for assessing muscle mass in clinical and epidemiological studies. Accumulating evidence from longitudinal cohort studies has demonstrated a significant association between sarcopenia and progressive cognitive decline in aging populations. To further elucidate this relationship, we conducted a comprehensive analysis using data from a nationally representative survey.

Nucleic Acid-Functionalized Gold Nanorods Modulate Inflammation and Dysregulated Intestinal Barriers for Treatment of Ulcerative Colitis.

Traditional oral treatments for ulcerative colitis (UC) face marked limitations including their single therapeutic effect, potential off-target interactions, and toxic side effects. In this study, we present nucleic acid-functionalized gold nanorods (NAF AuNRs), a biocompatible nanomaterial designed for the oral treatment of dextran sulfate sodium (DSS)-induced colitis. The NAF AuNRs alleviate immune responses by inhibiting pro-inflammatory macrophages and enhancing the expression of barrier proteins in intestinal epithelial cells.

Poly-T-Modified Gold Nanorods Suppress Macrophage-Mediated Inflammation for Periodontitis Therapy.

Traditional treatments for periodontitis are limited by their inability to adequately modulate the immune response and control inflammation. Recently, nucleic acid-modified nanomaterials have attracted significant attention for their potential in regulating inflammation. Among these, most nanomaterials, such as spherical nucleic acids, tend to exhibit pro-inflammatory effects.

Potential impacts of polyethylene microplastics and heavy metals on Bidens pilosa L. growth: Shifts in root-associated endophyte microbial communities.

This study investigates the impact of polyethylene (PE) microplastics of varying particle sizes and concentrations on the growth of Bidens pilosa L. and its root-associated microbial communities in cadmium (Cd) and lead (Pb) co-contaminated soil. PE microplastics had a significant impact on plant growth.

Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue.

Obesity and its related metabolic disorders seriously threaten our health and significantly reduce our life expectancy. The aim of the present study was to explore the effects of bone marrow mesenchymal stem cells (BMSCs) on high-fat diet (HFD)-induced obesity mice. The results demonstrated that BMSCs significantly reduced body weight, improved glucose tolerance and insulin sensitivity in obese mice.

Tunable Transparent Conductors Based on SnO: Theoretical and Experimental Studies of Codoping.

Transparent conducting oxides (TCOs) are widely used in modern electronics because they have both high transmittance and good conductivity, which is beneficial for many applications such as light-emitting diodes. Tailoring electronic states and hence the conductive types by design is important for developing new materials with optimal properties for TCOs. SnO, with a wide band gap, low cost, no toxins, and high stability, is a promising host material for TCOs.

Bioactive components in for treating Hashimoto's disease via regulation of innate immune response in human thyrocytes.

Background: Hashimoto's thyroiditis (HT) is a thyroid autoimmune disease characterized by lymphocytic infiltration and thyroid destruction. () is a traditional Chinese herbal medicine with documented clinical efficacy in treating HT. We previously reported an immunoregulatory effect of in thyrocytes; however, the bioactive components of remained unclear.

Genetically predicted metabolites mediate the causal associations between autoimmune thyroiditis and immune cells.

Introduction: We aimed to comprehensively investigate the causal relationship between 731 immune cell traits and autoimmune thyroiditis (AIT) and to identify and quantify the role of 1400 metabolic traits as potential mediators in between.

Methods: Using summary-level data from genome-wide association studies (GWAS) we performed a two-sample bidirectional Mendelian randomization (MR) analysis of genetically predicted AIT and 731 immune cell traits. Furthermore, we used a two-step MR analysis to quantify the proportion of the total effects (that the immune cells exerted on the risk of AIT) mediated by potential metabolites.

The Influence of Emodin Succinyl Ethyl Ester on Non-alcoholic Steatohepatitis Induced by a Diet High in Fructose, Cholesterol, and Fat in Mice.

Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis and evidence of hepatocyte injury (ballooning) and inflammation, with or without liver fibrosis. In this study, after 12 weeks of induction, the mice were treated with emodin succinyl ethyl ester (ESEE) for four weeks at doses of 10/30/90 mg/kg/d. The blood analysis of experimental endpoints showed that ESEE exhibited significant therapeutic effects on the progression of disorders of glycolipid metabolism and the induced liver injury in the model animals.

Intraoperative frozen section for determining the extent of surgery in papillary thyroid carcinoma: comprehensive risk factor assessment.

Background: There is much debate on the optimal treatment approach of papillary thyroid carcinoma (PTC). Different guidelines base recommendations on various risk factors. While diagnosing the various risk factors is difficult due to the technical limitations, intraoperative frozen section (IFS) may be a feasible method.

Memantine Attenuates Cognitive and Emotional Dysfunction in Mice with Sepsis-Associated Encephalopathy.

Sepsis-associated encephalopathy (SAE) is the most common complication of sepsis, with increased morbidity and mortality. To date, there has still been no established pharmacological therapy. Memantine, as an NMDA (-methyl-d-aspartate) receptor antagonist, exhibited neuroprotective effects against cognitive and emotional dysfunction in many disorders.

[Protective effect of barium chloride pretreatment on lung in mice with acute respiratory distress syndrome].

Objective: To explore whether barium chloride (BaCl) preconditioning has the protective effect on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) model in mice and the possible mechanism.

Methods: Sixty 8-12 week old healthy C57BL/6 male mice were randomly divided into control group, ARDS model group and BaCl pretreatment group, with 20 mice in each group. The BaCl pretreatment group was continuously injected with BaCl (4 mg/kg through the tail vein) for 3 days before ARDS model establishment.

The Combined Use of Platelet-Rich Plasma Clot Releasate and Allogeneic Human Umbilical Cord Mesenchymal Stem Cells Rescue Glucocorticoid-Induced Osteonecrosis of the Femoral Head.

Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a refractory disease. The treatment options for ONFH, especially nonsurgical ones, merit further investigation. To evaluate the combinatorial therapeutic effects of platelet-rich plasma clot releasate (PRCR) and umbilical cord mesenchymal stem cells (UC-MSCs) on glucocorticoid-induced ONFH, a dexamethasone (DEX)-treated cell model and a high-dose methylprednisolone (MPS)-treated rat model were established.

Clinical Value of the Lactate/Albumin Ratio and Lactate/Albumin Ratio × Age Score in the Assessment of Prognosis in Patients With Sepsis.

To examine the clinical significance of the blood lactate (Lac)/serum albumin (Alb) ratio and the Lac/Alb × age score for assessing the severity and prognosis of patients with sepsis. A total of 8,029 patients with sepsis, aged >18 years were enrolled between June 2001 to October 2012 from the latest version of the Medical Information Mart for Intensive Care III (MIMIC-III v.1.

Accuracy and Feasibility of Ultrasound-Guided Intra-articular Injection of the Rat Hip Joint.

Intra-articular injection is frequently used as an effective diagnostic and treatment tool for hip joint diseases. However, the underlying treatment mechanism remains unclear because of a lack of experimental animal models. A challenge facing researchers is how to accurately and consistently perform injections involving animal hip joints.