Identification of a Pseudomonas brassicacearum strain as a potential biocontrol agent against clubroot in cruciferous plants through endophytic bacterial community analysis and culture-dependent isolation.

Background: Clubroot, caused by Plasmodiophora brassicae, significantly impacts cruciferous crop production worldwide. Biocontrol is an environmentally friendly and promising approach for clubroot management. Endophytic bacteria are known for their ability to promote plant growth and induce resistance against plant diseases.

A xanthone O-glucoside isolated from Iris setosa Pall. ex Link exhibits promising anti-amoebic activity against the brain-eating amoeba Naegleria fowleri.

Background: Primary amoebic meningoencephalitis (PAM), caused by Naegleria fowleri, poses a significant challenge in humans owing to its high mortality rate, exceeding 97 %. Current therapeutics have been unable to deliver satisfactory treatment outcomes, due to suboptimal efficacy and toxicity, highlighting the critical need for efficacious drug development. In this study, we identified a natural compound, 3,5-Dihydroxy-8‑methoxy-1-O-β-d-glucopyranosyl xanthone (DX), which exhibited promising anti-N.

Investigating the Potential Effects of 6PPDQ on Clear Cell Renal Cell Carcinoma via Network Toxicology and Molecular Docking Analysis With In Vitro Experimental Validation.

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ), as a recently identified environmental toxicant, has garnered significant attention because of its widespread detection in ecosystems and human habitats. Emerging evidence highlights its potential detrimental effects on various organs. However, its carcinogenic potential remains poorly understood, particularly its role in clear cell renal cell carcinoma (ccRCC).

Risk prediction and driver tracking based on watershed resilience dynamics: A case study in Dahei River Basin, China.

The watersheds face increasing pressure from both human activities and natural factors, which exacerbate potential risks and pose significant challenges to integrated watershed management. This study developed an effective methodology to evaluate watershed sustainability and predict potential risks based on watershed resilience dynamics by combining catastrophe theory, adaptive cycle theory, and the Copula-Bayesian Network. Taking the Dahei River Basin (DRB) in China as a case study, we systematically evaluated the resilience dynamics, diagnosed risks, and tracked key driving factors to propose management strategies.

Hydrogel adhesives with a hydrodynamically induced liquid-solid transition for annular fissure sealing and inflammation modulation following microdiscectomy.

Background: Intervertebral disc (IVD) herniation is a major cause of low back pain and disability, with microdiscectomy being the standard surgical treatment. However, microdiscectomy fails to address annulus fibrosus (AF) defects, increasing the risk of recurrent herniation. Current therapeutic strategies for this condition remain limited in efficacy.