Attenuation of Ca signaling by overexpression of PMCA2 affects the microglial response to pathological events.

Microglia strongly impact the pathologic course of brain diseases and injuries. Intracellular Ca dynamics serve as central integrators, connecting microglial sensing capacity to their responses. We generated a mouse line with microglial overexpression of plasma membrane Ca-ATPase (PMCA)2, a central regulator of cytoplasmic Ca homeostasis.

Structure transition and gel melioration of ι-carrageenan and non-gelling senna tora gum mixed gel.

This study explored the potential of senna tora gum (STG) to modulate the gelation behavior and microstructure of iota-carrageenan (IC) in order to develop improved polysaccharide-based gels. Rheological and textural analyses revealed that STG significantly increased IC's gel strength without altering its structure. At an optimal STG concentration of 0.

Can physical exercise promote political participation among the elderly? A mediating analysis of social networks and the moderating role of higher education.

Objectives: Grounded in social capital theory, social network theory, and human capital theory, this study investigates how physical exercise fosters political participation among elderly individuals by enhancing community trust, expanding interpersonal ties, and improving physical and cognitive capacity. This study examines the impact of physical exercise on the political participation of elderly individuals, with a particular focus on the mediating role of social networks and the moderating effect of higher education.

Methods: Using 2,423 samples from the 2021 CGSS, we employ logit regression and OLS to analyze the relationship between physical exercise and political participation.

Presumed periodontitis and multimorbidity patterns: a prospective cohort study in the UK Biobank.

Objectives: To examine the pattern of multimorbidity among people with high risk of periodontitis.

Materials And Methods: Over 358,000 UK Biobank participants aged 40-69 years at baseline who took part in the baseline assessment and answered mouth/teeth dental problems were included (2006-2010). Cox proportional hazard models and logistic regression models were used to estimate the association of the risk factors of periodontitis with chronic diseases and multimorbidity, stratified by follow-up time.

The association between Chlamydia pneumoniae infection and prognosis in lung cancer patients: a prospective study.

Background: The prognostic value of Chlamydia pneumoniae (Cpn) infection in postoperative lung cancer patients remains unclear. This study aimed to evaluate the association between Cpn infection and survival in lung cancer patients.

Methods: This study included 309 newly diagnosed primary lung cancer patients from three hospitals in Fuzhou, China.

Enhanced sediment microbial diversity in mangrove forests: Indicators of nutrient status in coastal ecosystems.

Coastal ecosystems are increasingly threatened by nutrient imbalances and environmental degradation, which can compromise their stability and productivity. We analyzed the sediment characteristics, microbial community structures, and nutrient cycling across three habitats: mangrove forests, seagrass beds, and bare beaches. The physicochemical properties (including pH, total nitrogen (TN), phosphorus (P), and potassium (K)) of the sediment samples were analyzed, and the microbial diversity was assessed using high-throughput sequencing.

Slightly acidic electrolyzed water treatment enhances the quality attributes and the storability of postharvest litchis through regulating the metabolism of reactive oxygen species.

Effects of slightly acidic electrolyzed water (SAEW) on the storability, quality attributes, and reactive oxygen species (ROS) metabolism of litchis were investigated. Results showed that SAEW-treated litchis presented better quality attributes and storability than control litchis. On storage day 5, the commercially acceptable fruit rate of control litchis was 42%, while SAEW-treated litchis displayed 59% higher rate of commercially acceptable fruit, 21% lower pericarp browning index, and 13% lower weight loss percentage than control litchis.

Application of standardized management and effect evaluation of chronic obstructive pulmonary disease patients using the big data center of the Internet of Things.

Objective: Early detection, diagnosis, treatment and management of chronic obstructive pulmonary disease can lower morbidity and perhaps mortality. This study aimed to evaluate the effect of the application of standardized management against the background of the rapid development of the big data center of modern internet of things technology.

Methods: Participants ≥40 years of age with chronic obstructive pulmonary disease presenting at Xiamen Medical College Affiliated Haicang Hospital from October 2019 to October 2020 were selected as the observation patients based on the Internet of Things big data center for chronic obstructive pulmonary disease standardized management, and control patients from the community were selected for without down to the chronic obstructive pulmonary disease standardized management.

TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages.

Triggering receptor expressed on myeloid cell 2 (TREM2), a myeloid cell-specific signaling molecule, controls essential functions of microglia and impacts on the pathogenesis of Alzheimer's disease and other neurodegenerative disorders. TREM2 is also highly expressed in tumor-associated macrophages in different types of cancer. Here, we studied whether TREM2 influences glioma progression.

Slightly acidic electrolyzed water treatment improves the quality and storage properties of carambola fruit.

This study aimed to explore the impacts of slightly acidic electrolyzed water (SAEW) treatment on the physiology, quality, and storage properties of postharvest carambola. The carambolas were immersed in SAEW with a pH value of 6.0, ORP of 1340 mV and ACC of 80 mg/L.

On-Chip Microdevice Unveils Reactant Enrichment Effect Dominated Electrocatalysis Activity in Molecular-Linked Catalysts.

Molecular functionalization has been intensely studied and artificially constructed to advance various electrocatalytic processes. While there is a widely approved charge-doping effect, the underlying action for reactant distribution/transport remains long neglected. Here an on-chip microdevice unravels that the proton enrichment effect at prototypical methylene blue (MB)/MoS interfaces rather than charge doping contributes to the hydrogen evolution reaction (HER) activity.

Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth.

Pyruvate dehydrogenase kinase-1 (PDK1), a key metabolic enzyme involved in aerobic glycolysis, is highly expressed in many solid tumors. Small molecule compound DAP (2,2-dichloroacetophenone) is a potent inhibitor of PDK1. Whether targeting PDK1 with DAP can inhibit acute myeloid leukemia (AML) and how it works remains unknown.

Hysteroscopic septum resection of complete septate uterus with cervical duplication, sparing the double cervix in patients with recurrent spontaneous abortions or infertility.

Objective: To evaluate the safety and efficacy of hysteroscopic septum resection of the complete septate uterus with cervical duplication in patients with recurrent spontaneous abortions or infertility.

Design: Prospective consecutive clinical study.

Setting: University hospital for obstetrics, gynecology, and reproductive medicine.

[Evaluation of a self-defined classification of uterine submucous myomas for guiding transcervical hysteroscopic electric resection].

Objective: To value a new presurgical classification system of submucous myomas for predicting the difficulty and the safety of hysteroscopic myomectomy.

Methods: The clinical data of 491 patients who underwent hysteroscopic resection of submucous myomas were analyzed. The myomas were classified according to the Classification of the European Society for Gynaecological Endoscopy (ESGE) and our group's new classification, which consists of five parameters.