Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Molecular functionalization has been intensely studied and artificially constructed to advance various electrocatalytic processes. While there is a widely approved charge-doping effect, the underlying action for reactant distribution/transport remains long neglected. Here an on-chip microdevice unravels that the proton enrichment effect at prototypical methylene blue (MB)/MoS interfaces rather than charge doping contributes to the hydrogen evolution reaction (HER) activity. Back-gated electrical/electrochemical tests detect quantitatively a strong charge injection from MB to MoS realized over diploid carrier density, but these excess carriers are unqualified for the actual enhanced HER activity (from 32 to 125 mA cm at -0.29 V). On-chip electrochemical impedance further certifies that the proton enrichment in the vicinity of MoS, which is generated by the nucleophilic group of MB, actually dominates the HER activity. This finding uncovers the leading function of molecular-linked catalysts.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.nanolett.2c04087 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sample-to-answer nucleic acid detection using a fully integrated microdevice for nucleic acid extraction and smartphone-based droplet digital RPA/CRISPR.
Biosens Bioelectron
December 2025
School of Instrument Science and Technology, State Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, Xi'an, 710054, Shaanxi, China; Key Laborat
Clustered regularly interspaced short palindromic repeats (CRISPR)-based nucleic acid detection has advanced rapidly due to its simplicity, high specificity, and high sensitivity. However, most conventional CRISPR-based detection methods lack quantitative capability. Although the strategy of digital PCR technology enhances the sensitivity of CRISPR detection and enables quantification analysis through sample dispersion, integration remains limited.
View Article and Find Full Text PDFReview on organ-on-chips for medicines safety assessment: A European regulatory perspective.
ALTEX
July 2025
European Medicines Agency, Amsterdam, The Netherlands.
This review examines a decade (2010-2020) of organ-on-chip (OoC) development, focusing on their application in the non-clinical safety assessment of medicinal products. It includes a detailed description of the types of OoCs, the organs, tissues and interactions mimicked, as well as their various applications. A broad range of organs and combinations of organs were modelled in the reviewed OoCs, with the liver, kidney and heart being the most frequently mimicked.
View Article and Find Full Text PDFMicrofluidic Production of Spatially Structured Biomimetic Microgels as Compartmentalized Artificial Cells.
Small Sci
April 2025
Institute of Chemical Biology Imperial College London Molecular Sciences Research Hub, 82 Wood Lane London W12 0BZ UK.
Artificial cells serve as promising micro-robotic platforms that replicate cellular features. One ubiquitous characteristic of living cells is compartmentalization of content in distinct and well-defined locations. Herein, a microfluidic strategy to mimic compartmentalization is developed through the production of micron-scale two and three compartment biomimetic microgels, where hydrogel compartment number, composition, size, and shape can be controlled.
View Article and Find Full Text PDFFabrication of a novel porous silicon biomembrane for applications in organ-on-chip technology.
Biomed Microdevices
June 2025
Department of Physics and Engineering, Fort Lewis College, Durango, CO, USA.
Conventional in vitro and preclinical animal models often fail to accurately replicate the complexity of human diseases, limiting the success of translational studies and contributing to the low success rate of clinical trials (Ingber 2016). In response, research has increasingly focused on organ-on-chip technology, which better mimics human tissue interfaces and organ functionality. In this study, we describe the fabrication of a novel biomembrane made of porous silicon (PSi) for use in organ-on-chip systems.
View Article and Find Full Text PDFLab on chips for liquid biopsy: a flexible and customized approach through microfabrication.
Biomed Microdevices
June 2025
CNR NANOTEC- Institute of Nanotechnology, via per Monteroni, Lecce, 73100, Italy.
Cancer early detection is one of the most challenging purposes of preventive medicine. Liquid biopsy represents a revolutionary approach, fostering access to early screening and increasing patients' compliance, two crucial issues in reaching the largest possible audience in prevention campaigns. To facilitate this approach, the deployment of innovative methods for easy manipulation of biological fluids and the availability of devices for the rapid and low-cost detection of biomarkers is essential.
View Article and Find Full Text PDF