Genomic Insights into Genetic Characteristics of - China, 2023.

What Is Already Known About This Topic?: (. ) is an emerging multidrug-resistant and potentially extensively drug-resistant pathogen capable of causing invasive, lethal infections in humans. Conventional biochemical and mass spectrometry identification methods used in clinical laboratories cannot reliably distinguish it from .

[Optimization and Application of Soil Health Evaluation Method for Edible Beans].

Edible beans play a significant role in healthy dietary structures， human health， and soil improvement. Scientifically and reasonably assessing the health status of the soil where they are cultivated is crucial for achieving green， high-yield， and high-quality production. This study focused on soils from major edible bean-producing areas across the country， collecting soil samples from 0-20 cm depth and measuring 27 indicators reflecting soil physical， chemical， and biological characteristics.

Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.

Background: Salmonella enterica (S. enterica) causes tens of thousands of cases of diarrheal disease worldwide each year. However, our understanding of the genome and transmission dynamics of S.

Genomic analysis of invasive and non-invasive disease-causing isolated from children between 2014 and 2023 in Suzhou, China.

In 2017, 553,000 clinical cases of in children were reported in China, although the pneumococcal conjugate vaccine (PCV), which targets the pneumococcal capsule, is not included in the Chinese National Immunization Program (NIP) for children. Therefore, the PCV uptake rate is very low. To investigate the population over the past 10 years in China, we collected 418 S.

A global atlas and drivers of antimicrobial resistance in Salmonella during 1900-2023.

Although previous studies using phenotypic or/and genomic approaches monitoring have revealed the spatiotemporal distribution of antimicrobial resistance (AMR) in Salmonella in local areas, their geographical patterns and driving factors remain largely unknown at a global scale. Here, we performed an analysis of publicly available data of 208,233 Salmonella genomes in 148 countries/regions between 1900 and 2023 and explored driving indicators of AMR. Overall, we found that the geographic distribution of AMR varied depending on the location, source, and serovar.

The First Case of Antimicrobial-Resistant Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.

Objective: To analyze the phenotypic and genomic characteristics of a non-typhoidal bile isolate from a patient with chronic diarrhoea secondary to acute cholecystitis.

Methods: The patient presented with chronic diarrhoea lasting for two weeks, which was secondary to acute cholecystitis. The non-typhoidal bile isolate was identified using biochemical tests, mass spectrometry, serum agglutination tests, and antimicrobial susceptibility testing.

Phenotypic and WGS-derived antibiotic resistance patterns of Enteritidis isolates from retail meat and environment during 2014 to 2019 in China.

The emergence of multidrug-resistant (MDR) Enteritidis has highlighted the importance of regularly monitoring for the occurrence of antibiotic-resistant strains. The current study combined phenotyping analysis and whole-genome-sequencing (WGS) to investigate the associations between the antibiotic-resistant phenotypes (ARPs) and genetic characteristics determinants in 95 Enteritidis isolates from retail meat and environmental samples in China (2014-2019). Phenotypic analyses revealed that 70 isolates (73.

An MDR Salmonella Enteritidis sublineage associated with gastroenteritis outbreaks and invasive disease in China.

Objectives: Salmonella enterica serovar Enteritidis (S. Enteritidis) is a commonly reported pathogen which adapts to multiple hosts and causes critical disease burden at a global level. Here, we investigated a recently derived epidemic sublineage with multidrug resistance (MDR), which have caused extended time-period and cross-regional gastroenteritis outbreaks and even invasive nontyphoidal Salmonella disease (iNTS) in China.

Genomic perspective on the bacillus causing paratyphoid B fever.

Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021.

Deciphering antibiotic resistance genes and plasmids in pathogenic bacteria from 166 hospital effluents in Shanghai, China.

Although previous studies using phenotypic or metagenomic approaches have revealed the patterns of antibiotic resistance genes (ARGs) in hospital effluents in local regions, limited information is available regarding the antibiotic resistome and plasmidome in human pathogenic bacteria in hospital effluents of megacity in China. To address this knowledge gap, we analyzed effluent samples from 166 hospitals across 13 geographical districts in Shanghai, China, using both cultivation-based approaches and metagenomics. A total of 357 strains were isolated from these samples, with the predominant species being Escherichia coli (n = 61), Aeromonas hydrophila (n = 57), Klebsiella pneumoniae (n = 48), and Aeromonas caviae (n = 42).

UM-Net: Rethinking ICGNet for polyp segmentation with uncertainty modeling.

Automatic segmentation of polyps from colonoscopy images plays a critical role in the early diagnosis and treatment of colorectal cancer. Nevertheless, some bottlenecks still exist. In our previous work, we mainly focused on polyps with intra-class inconsistency and low contrast, using ICGNet to solve them.

Dynamic antimicrobial resistance and phylogenomic structure of Typhimurium from 2007 to 2019 in Shanghai, China.

Unlabelled: serovar Typhimurium is an important foodborne pathogen associated with human salmonellosis worldwide. A retrospective screening was performed to elucidate the prevalence, antimicrobial resistance, and phylogenomic characterization of this pathogen in Shanghai, China. .

Genomic investigation of Salmonella enterica Serovar Welikade from a pediatric diarrhea case first time in Shanghai, China.

Background: Salmonella, an important foodborne pathogen, was estimated to be responsible for 95.1 million cases and 50,771 deaths worldwide. Sixteen serovars were responsible for approximately 80% of Salmonella infections in humans in China, and infections caused by a few uncommon serovars have been reported in recent years, though not with S.

Grumpensis Causing Diarrhea in Children - Shanghai Municipality, China, 2023.

What Is Already Known About This Topic?: Foodborne diseases are a growing public health concern with a notable disease burden in China.

What Is Added By This Report?: Two children with diarrhea visited a healthcare facility within 24 hours on August 1 and 2, 2023. Grumpensis was detected in their stool samples by the public health laboratory.

Dissemination of IncC plasmids in Salmonella enterica serovar Thompson recovered from seafood and human diarrheic patients in China.

Salmonella Thompson is a prevalent foodborne pathogen and a major threat to food safety and public health. This study aims to reveal the dissemination mechanism of S. Thompson with co-resistance to ceftriaxone and ciprofloxacin.

Computer aided diagnosis of diabetic retinopathy based on multi-view joint learning.

Diabetic retinopathy (DR) is a kind of ocular complication of diabetes, and its degree grade is an essential basis for early diagnosis of patients. Manual diagnosis is a long and expensive process with a specific risk of misdiagnosis. Computer-aided diagnosis can provide more accurate and practical treatment recommendations.

Antimicrobial Resistance and Molecular Characterization of Rissen Isolated in China During 2008-2019.

Background: This study aimed to provide epidemiological features of serovar Rissen, determine antimicrobial susceptibility, virulence gene profiles, and describe the potential association of . Rissen from different sources in China.

Methods: During 2008-2019, a total of non-repetitive 228 .

Small extracellular vesicle microRNAs in pediatric myasthenia gravis plasma and skeletal muscle.

Background: The diagnosis of myasthenia gravis (MG) in children remains difficult. Circulating small extracellular vesicle (sEV)-derived miRNAs (sEV-miRNAs) have been recognized as biomarkers of various diseases and can be excreted by different cell types. These biomarker candidates also play a vital role in autoimmune diseases via intercellular communication.

An integrated nationwide genomics study reveals transmission modes of typhoid fever in China.

Typhoid fever is a life-threatening disease caused by serovar Typhi, resulting in a significant disease burden across developing countries. Historically, China was very much close to the global epicenter of typhoid, but the role of typhoid transmission within China and among epicenter remains overlooked in previous investigations. By using newly produced genomics on a national scale, we clarify the complex local and global transmission history of such a notorious disease agent in China spanning the most recent five decades, which largely undermines the global public health network.