Microbial biofilm-based hydrovoltaic pressure sensor with ultrahigh sensitivity for self-powered flexible electronics.

Developing the integration of self-powered detection with both dynamic and static forces is a significant challenge in promoting intelligent technology systems. Herein, we introduce an innovative microbial biofilm based-hydrovoltaic pressure sensor (mBio-HPS) using whole-cell Geobacter sulfurreducens, which successfully combines self-powered functionality and static pressure detection within a single device. The mBio-HPS exhibited a sensitivity of up to 8968.

Viral infection induces inflammatory signals that coordinate YAP regulation of dysplastic cells in lung alveoli.

Severe viral pneumonia can induce rapid expansion of KRT5+ basal-like cells in small airways and alveoli; this forms a scar-like structure that persists in the injured alveoli and impedes normal alveolar epithelium regeneration. In this study, we investigated the mechanism by which viral infection induced this remodeling response. Through comparing different lung-injury models, we demonstrated that infection induced strong IFN-γ signal-stimulated dysplastic KRT5+ cell formation.

Alveolar regeneration by airway secretory-cell-derived p63 progenitors.

Lung injury activates epithelial stem or progenitor cells for alveolar repair and regeneration. Unraveling the origin and fate of injury-induced progenitors is crucial for elucidating lung repair mechanisms. Here, we report that p63-expressing progenitors emerge upon bleomycin-induced mouse lung injury.

Design strategies for VR science and education games from an embodied cognition perspective: a literature-based meta-analysis.

Introduction: Natural science education, as an important means to improve the scientific literacy of citizens, combines science education games with virtual reality (VR) technology and is a major developmental direction in the field of gamified learning.

Methods: To investigate the impact of VR science education games on learning efficiency from the perspective of embodied cognition, this study uses the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases as the main source of samples. A meta-analysis of 40 studies was conducted to examine teaching content, game interaction, and immersion mode.

Ultralow Dark Current (6 fA at 1 V) in Quasi-Two-Dimensional CsGaGeSe Single Crystals for High Signal-to-Noise Ratio Photodetectors under Strong Electron Localization.

To satisfy the demands of photodetectors for weak-light detection, materials selected for device fabrication should have an extremely low background carrier concentration to suppress the dark current of devices. In this work, a new quasi-two-dimensional CsGaGeSe single crystal with an extremely low background carrier concentration was synthesized by a co-solvent reaction based on which a photoconductive detector was prepared with an ultralow dark current density (6 fA at 1 V and ∼10 A cm) and a high response speed (∼0.74 s) was achieved, presenting a great potential of being applied to the field of weak-light detection.

Application of Graphene-Combined Rare-Earth Oxide (SmO) in Solar-Blind Ultraviolet Photodetection.

Rare-earth oxide SmO is theoretically expected to be used in the preparation of ultraviolet (UV) detectors with low dark currents and high radiation resistance due to its characteristics of a wide bandgap, a high dielectric constant, and high chemical stability. However, certain features that rare-earth oxides possess, such as high resistivity and weak photoelectric response currents, have hindered relevant research on these kinds of materials in the field of UV detection. In this work, a -Gr/-SmO/-SiC heterojunction photovoltaic solar-blind UV sensor was constructed for the first time.

The Effects and Regulatory Mechanism of Casein-Derived Peptide VLPVPQK in Alleviating Insulin Resistance of HepG2 Cells.

The liver plays a key role in keeping the homeostasis of glucose and lipid metabolism. Insulin resistance of the liver induced by extra glucose and lipid ingestion contributes greatly to chronic metabolic disease, which is greatly threatening to human health. The small peptide, VLPVPQK, originating from casein hydrolysates of milk, shows various health-promoting functions.

Cardiac resynchronization therapy in heart failure patients by using left bundle branch pacing.

Background: Left bundle branch pacing (LBBP) is emerging as an effective alternative to achieve cardiac resynchronization therapy (CRT) and improve heart function. The purpose of our study was to investigate the feasibility and efficacy of LBBP in heart failure patients with left ventricular ejection fraction (LVEF) <50% and left bundle branch block (LBBB).

Methods: All patients with complete LBBB and LVEF <50% were retrospectively included in the study from April 2018 to April 2021 and underwent CRT LBBP implantation.

Nicotinamide Riboside Alleviates Cardiac Dysfunction and Remodeling in Pressure Overload Cardiac Hypertrophy.

Background: Cardiac hypertrophy is a compensatory response to pressure overload, which eventually leads to heart failure. The current study explored the protective effect of nicotinamide riboside (NR), a NAD booster that may be administered through the diet, on the occurrence of myocardial hypertrophy and revealed details of its underlying mechanism.

Methods: Transverse aortic constriction (TAC) surgery was performed to establish a murine model of myocardial hypertrophy.