Choroidal Venous Architecture and Polypoidal Lesion Distribution in Subtypes of Polypoidal Choroidal Vasculopathy Using Widefield Imaging.

Purpose: To investigate the spatial relationship between choroidal vortex veins (VVs), choroidal watershed zones (CWZs), and polypoidal lesion distribution in different subtypes of polypoidal choroidal vasculopathy (PCV) categorized by choroidal vascular hyperpermeability (CVH) status.

Methods: This retrospective study analyzed 58 treatment-naïve PCV eyes using widefield imaging to map dominant VVs, CWZs, and lesion locations. Eyes were stratified into CVH (n = 32) and non-CVH (n = 26) groups.

Strongly enhanced topological quantum phases in dual-surface AlO-encapsulated MnBiTe.

The topological quantum phases in antiferromagnetic topological insulator MnBiTe hold promise for next-generation spintronics, but their experimental realization has been constrained by challenges in preparing high-quality devices. In this work, we report a new wax-assisted exfoliation and transfer method that enables the fabrication of MnBiTe heterostructures with both surfaces encapsulated by AlO. This strategy strongly enhances the transport performances of the topological quantum phases in MnBiTe flakes, which is attributed to the enhancement of magnetism by the AlO layer.

Nanopore targeted sequencing identifies pathogens in patients with postoperative endophthalmitis.

Aim: To estimate if nanopore targeted sequencing (NTS) could identify pathogens causing postoperative endophthalmitis and further determine the feasibility of clinical application of NTS.

Methods: A total of 55 patients (55 eyes) with postoperative endophthalmitis were retrospectively included in this study with their medical records. Intraocular fluid samples were examined by NTS and microbial culture.

Association between early lesion response and long-term anti-VEGF injection frequency in nAMD: a 2-year prospective study using 3D volumetric analysis.

Purpose: To explore the association between early response of different lesions and the number of anti-vascular endothelial growth factor (anti-VEGF) injections in neovascular age-related macular degeneration (nAMD).

Methods: This prospective study included treatment-naïve nAMD eyes with a 2-year follow-up period. Volumetric changes of multiple lesions during the loading phase were documented, including subretinal fluid (SRF), intraretinal fluid (IRF), vascular subretinal hyper-reflective material (vSHRM) and avascular subretinal hyper-reflective material, fibrovascular pigment epithelial detachment and serous pigment epithelial detachment (sPED) and total lesion.

Evaluation of Choroidal Vein Distribution Pattern and Choroidal Vessel Parameters in Patients With Central Serous Chorioretinopathy Using Widefield ICGA and Widefield OCTA.

Purpose: To evaluate the choroidal vein distribution pattern in eyes with central serous chorioretinopathy (CSC) using widefield indocyanine green angiography (WF-ICGA) and widefield optical coherence tomography angiography (WF-OCTA).

Design: Retrospective, comparative validity and reliability analysis.

Subject: Patients diagnosed with CSC between September 2022 and September 2024.

Multimodal imaging biomarkers of subretinal hyperreflective material accumulation in central serous chorioretinopathy.

Purpose: To identify multimodal imaging (MMI) biomarkers associated with subretinal hyperreflective material (SHRM) in central serous chorioretinopathy (CSC).

Methods: This retrospective study enrolled eyes with primary and recurrent CSC with symptoms lasting less than 3 months. Eyes were categorized into two groups based on the presence or absence of SHRM, with SHRM-positive eyes further subdivided into three grades.

Prognostic value of macular neovascularisation characteristics for photoreceptor integrity in nAMD: a prospective observational study.

Purpose: To explore the relationship between characteristics of macular neovascularisation (MNV) and photoreceptor integrity in patients with neovascular age-related macular degeneration (nAMD).

Methods: This prospective study enrolled treatment-naïve nAMD eyes and conducted a 3-month follow-up. 16 quantitative MNV features were evaluated using optical coherence tomography angiography, and the impaired areas of ellipsoid zone (EZ), external limiting membrane (ELM) and outer nuclear layer (ONL) were obtained using optical coherence tomography.

Widefield indocyanine green angiography evaluating choroidal vein drainage pattern and choroidal vein alterations in acute and chronic central serous chorioretinopathy.

Purpose: To access the distribution of choroidal vein drainage pattern and the choroidal vein alterations in choroidal vascular hyperpermeability (CVH) areas in eyes with acute and chronic central serous chorioretinopathy (CSC) using widefield indocyanine green angiography (WF-ICGA).

Methods: In this retrospective observational study, medical records and multimodal imaging of 127 patients (165 eyes) with CSC were reviewed. The number and location of dominant vortex veins and CVH areas on WF-ICGA images were evaluated.

Molecular Responses of Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration: Integrative Insights From Multi-Omics and Clinical Imaging.

Purpose: The purpose of this study was to investigate the molecular mechanisms underlying anti-vascular endothelial growth factor (anti-VEGF) efficacy and response variability in neovascular age-related macular degeneration (nAMD) using longitudinal proteomic and metabolomic analysis alongside three-dimensional lesion measurements.

Methods: In this prospective study, 54 treatment-naive patients with nAMD underwent "3+ pro re nata" (3+PRN) anti-VEGF regimens followed for at least 12 weeks. Aqueous humors were collected pre- and post-treatment for proteomic and metabolomic analysis.

Association between three-dimensional morphological features and functional indicators of neovascular age-related macular degeneration.

Purpose: To investigate the correlation between morphological lesions and functional indicators in eyes with neovascular age-related macular degeneration (nAMD).

Methods: This was a prospective observational study of treatment-naïve nAMD eyes. Various morphological lesions and impaired retinal structures were manually measured at baseline and month-3 in three-dimensional optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) images, including the volumes (mm) of macular neovascularization (MNV), avascular subretinal hyperreflective material (avascular SHRM), subretinal fluid (SRF), intraretinal fluid (IRF), serous pigment epithelial detachment (sPED) and the impaired area (mm) of ellipsoid zone (EZ), external limiting membrane (ELM) and outer nuclear layer (ONL).

Analyzing Formation and Absorption of Avascular Subretinal Hyperreflective Material in nAMD From OCTA-Based Insights.

Purpose: To investigate the formation and absorption of avascular subretinal hyperreflective material (avSHRM) in neovascular age-related macular degeneration (nAMD) based on optical coherence tomography angiography (OCTA) characteristics.

Design: Prospective cohort study.

Methods: This study included patients with treatment-naive nAMD who were followed up for 3 months.

A prospective observation of influence of anti-VEGF on optic disc vasculature in nAMD patients.

Background: This study aims to investigate the short-term changes in relatively normal retinal vessels following anti-vascular endothelial growth factor (anti-VEGF) therapy in nAMD patients, an area that currently represents a research gap.

Methods: In this prospective study, we enrolled patients newly diagnosed with neovascular age-related macular degeneration (nAMD) and received standardized monthly anti-VEGF therapy for three months. Follow-ups were conducted at baseline and 1-week, 1-month, 2-months and 3-months post first injection.

The diagnostic utility of nanopore targeted sequencing in suspected endophthalmitis.

Purpose: This paper aimed to assess the diagnostic utility of a newly developed gene-based technology-nanopore targeted sequencing (NTS) in suspected endophthalmitis patients.

Methods: This retrospective study included 43 patients (44 eyes) with suspected endophthalmitis. NTS was applied along with microbiological culture to detect unknown pathogens in intraocular fluid samples.

IDENTIFICATION OF PATHOGENS IN THE INTRAOCULAR FLUID SAMPLES OF PATIENTS WITH ENDOGENOUS ENDOPHTHALMITIS USING RAPID NANOPORE TARGETED SEQUENCING.

In Brief: Nanopore targeted sequencing showed a higher positivity rate and a shorter turnaround time than did traditional culture in identifying pathogens in the intraocular fluid samples of patients with endogenous endophthalmitis.

Purpose: To evaluate the feasibility of clinical application of nanopore targeted sequencing (NTS) for the identification of pathogens in patients with endogenous endophthalmitis, especially those with fungus-associated endophthalmitis.

Methods: In this retrospective study, medical records and etiological results of 27 patients (34 eyes) with endogenous endophthalmitis were reviewed.

The Clinical Effect of High-Flow Oxygen Therapy through the Nose on Patients with Acute Left Heart Failure and Hypoxemia.

Objective: To evaluate the clinical efficacy of nasal high-flow oxygen therapy in patients with acute left heart failure and hypoxemia.

Methods: From July 2016 to November 2018, patients with acute left heart failure complicated with hypoxemia treated in the Department of Critical Medicine of Yantai Affiliated Hospital of Binzhou Medical University were retrospectively observed (a total of 140 cases met the inclusion criteria). They were randomly divided into two groups, with 70 cases in each group.

Dynamic changes of scleral spur length in different accommodation stimuli states.

This study aimed to evaluate the scleral spur length (SSL) in response to different accommodation stimuli states, as well as the correlation with Schlemm's canal (SC) and trabecular meshwork (TM). 74 children were recruited for this study. The 0D, - 4D, and - 8.