Short-term outcomes of intravenous tenecteplase compared with alteplase for mild acute ischemic stroke.

Background: To investigate the short-term outcomes of intravenous tenecteplase compared with alteplase for patients with mild acute ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score ≤ 5 points).

Methods: We performed a retrospective analysis of 226 mild stroke patients in the Stroke Center Registry database who received intravenous thrombolysis from May 2010 to December 2023. The primary outcome was excellent functional prognosis (modified Rankin scale [mRS] score of 0-1) at discharge.

Acquired hemophilia A secondary to cholangiocarcinoma: A case report and literature review.

Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder. Its occurrence secondary to hepatobiliary malignancies is even rarer, and without timely diagnosis and treatment, the mortality rate is extremely high. There is a need to raise awareness of this disease.

Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke.

Background: To investigate the effect of eosinophils on early (END) and delayed neurological deterioration (DND) after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS).

Methods: A total of 442 consecutive AIS patients experiencing MT between May 2017 and January 2023 were analyzed. END and DND were defined as a rise of ≥ 2 points on the National Institutes of Health Stroke Scale (NIHSS) or a fall of ≥ 1 point on the Glasgow Coma Scale or death from baseline to 24 h and from 24 to 72 h, respectively.

Spatial Patterns and Composition Traits of Soil Microbial Nitrogen-Metabolism Genes in the Forests at a Regional Scale.

Microbial-driven processes related to the nitrogen-metabolism (N-metabolism) in soil are critical for ecosystem functioning and stability. There are spatial patterns of microbial-mediated nitrogen processes, but we still lack an overview of the soil N-metabolism genes of single nitrogen-fixing tree species pure forests at a regional scale. Here, we investigated the spatial variation and drivers of microbial N-metabolism genes in the rhizosphere soil of on the Loess Plateau by metagenomic technology.

Deep Symmetric Adaptation Network for Cross-Modality Medical Image Segmentation.

Unsupervised domain adaptation (UDA) methods have shown their promising performance in the cross-modality medical image segmentation tasks. These typical methods usually utilize a translation network to transform images from the source domain to target domain or train the pixel-level classifier merely using translated source images and original target images. However, when there exists a large domain shift between source and target domains, we argue that this asymmetric structure, to some extent, could not fully eliminate the domain gap.

Efficacy of albumin-bound paclitaxel in the treatment of advanced refractory breast cancer and its effect on serum resistin.

Purpose: This study aimed to investigate the efficacy of albumin-bound paclitaxel (nab-paclitaxel) in the treatment of advanced refractory breast cancer (BC) and its effect on serum resistin.

Methods: A retrospective study was performed based on the clinical records of 95 patients with advanced refractory BC admitted to Weihai Central Hospital from March 2012 to May 2015. Thirty-four patients were treated with traditional paclitaxel and enrolled in the control group, while the other 61 patients were treated with nab-paclitaxel and enrolled in the study group.

Clinical significance of breast-conserving surgery for early breast cancer and its impact on patient life quality of life.

Purpose: To explore the clinical significance of breast-conserving surgery for early breast cancer and its impact on patient's life quality.

Methods: We retrospectively analyzed 156 patients with early breast cancer who were admitted to Weihai Municipal Hospital between August 2013 and January 2015. Among them, there were 82 cases of breast-conserving surgery (the experiment group) and 74 cases of conventional radical surgery (the control group).

Long non-coding RNA NKILA serves as a biomarker in the early diagnosis and prognosis of patients with colorectal cancer.

Colorectal cancer (CRC) is one of the leading causes of cancer-associated mortality worldwide. The prognosis of patients with CRC at an advanced stage is poor. Biomarkers currently used in clinical practice, including carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9, lack sufficient sensitivity and specificity for early diagnosis and prediction, therefore there remains a requirement to improve the prognosis of patients with CRC.

MicroRNA-937 inhibits the malignant phenotypes of breast cancer by directly targeting and downregulating forkhead box Q1.

Numerous microRNAs (miRNAs) are aberrantly expressed in breast cancer, and the dysregulation of miRNAs may affect the aggressiveness of this cancer. Aberrant expression of miRNA-937 (miR-937) in gastric and lung cancers has been reported, which plays tumor-suppressive or oncogenic roles in carcinogenesis including cancer progression. Our purpose was to investigate the involvement of miR-937 in breast cancer progression.

Removal of Cr(VI) from aqueous solution by flocculant with the capacity of reduction and chelation.

A novel agent polyethyleneimine-sodium xanthogenate (PEX) with the multifunction of reduction, chelation, flocculation and precipitation was synthesized by using polyethyleneimine (PEI), carbon disulfide (CS2), and sodium hydroxide (NaOH). The effects of different important parameters, such as pH value, initial Cr(VI) concentration, coexisting ions and turbidity etc., on the removal of chromium from aqueous solution by PEX were investigated in flocculation experiments.