Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD metabolism and promoting IDO2/QPRT expression.

Background: Imbalances in nicotinamide adenine dinucleotide (NAD) homeostasis accelerate aging, and targeting NAD metabolism is a potential strategy for delaying aging. Ginsenoside, as the main active ingredient of Panax ginseng Meyer, exert age-delaying effects. However, the potential molecular mechanism by which total ginsenosides (GS) affect NAD metabolism remains unclear.

Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines.

The role of polysaccharides in quality control of ginseng is underestimated. Large-scale comparison on the polysaccharides of Panax ginseng (PG), P. quinquefolius (PQ), P.

Impact of dedicated infectious disease teamwork on the treatment and prognosis of patients with diabetic foot infection.

Objective: The aim was to develop and evaluate the impact of a new model in which the infectious disease (ID) physician and pharmacist work together to treat diabetic foot infections (DFIs).

Methods: A quasi-experimental before-after study was conducted. The medical charts of inpatients with DFI admitted between April 1, 2017 and March 31, 2018 were reviewed retrospectively (control group, n = 30).

An Indole Alkaloid Extracted from Inhibits Colonic Motility of Rats .

Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb . Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown. The aim of this study was to investigate the effect of Evo on colonic motility of rats and the underlying mechanisms .

Submucosal tunneling endoscopic resection for large symptomatic submucosal tumors of the esophagus: A clinical analysis of 24 cases.

Background/aims: Studies evaluating submucosal tunneling endoscopic resection (STER) for the treatment of upper gastrointestinal submucosal tumors (SMTs) have recently increased. However, the efficacy and safety of STER for the treatment of large symptomatic SMTs in the esophagus have not been well investigated. The aim of the present study was to evaluate the efficacy and safety of STER for the treatment of large symptomatic SMTs in the esophagus.

Current Status and Problem-Solving Strategies for Ginseng Industry.

Ginseng is a plant in the family Araliaceae and the genus Panax with the formal name of Panax ginseng C. A. Meyer and the treasure of traditional herbal medicine resources as the "king of herbs".

Successful treatment of a rare extended retroperitoneal necrotizing soft tissue infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: A case report.

Rationale: Retroperitoneal necrotizing soft tissue infection (NSTI) is a rare but life-threatening disease. Here, we present a case of extended retroperitoneal NSTI caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E coli).

Patient Concerns: The patient complained of progressive redness, swelling, and right flank pain for 10 days, extending to the scrotum for 1 day.

Nutritional risk screening and clinical outcome assessment among patients with community-acquired infection: A multicenter study in Beijing teaching hospitals.

Objective: The aim of this study was to implement nutritional risk screening in patients with community-acquired infection (CAI) and analyze its relationship with clinical outcomes.

Methods: We consecutively assessed 595 patients with CAI from two teaching hospitals for eligibility during this study. Their nutritional risk was evaluated using Nutritional Risk Screening-2002.

A novel bisindolymaleimide derivative (WK234) inhibits proliferation and induces apoptosis through the protein kinase Cβ pathway, in chronic myelogenous leukemia K562 cells.

WK234, a novel bisindolymaleimide derivative, was designed as a protein kinase Cβ (PKCβ) inhibitor. The objective of this study was to evaluate the anti-tumor activity of WK234 in the human chronic myelogenous leukemia (CML) K562 cell line and to investigate possible mechanisms of its action. The results show that WK234 inhibited K562 cell proliferation in a time- and dose-dependent manner.

Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates.

A series of novel bisindolylmaleimide and natural amino acid ester conjugates were synthesized and evaluated for their inhibitory activity against six tumor cell lines. Some compounds displayed interesting cytotoxic profiles. The most active compound 8e showed inhibitory activity against several human cancer cell lines.

[Role of PKCbeta in the malignant tumors and enzastaurin, a PKCbeta inhibitor].

Protein kinase C beta (PKCbeta) is a multifunctional serine/threonine protein kinase, which plays an important role in many cell signaling pathways. PKCbeta takes part in multiple physiological processes, including regulation of the cell cycle, differentiation, proliferation, apoptosis and angiogenesis. Increased PKCbeta activity has been observed in many human cancers, such as colon, breast and haematological malignancies.