Key indicators for guiding tocilizumab therapy to prevent orbital decompression surgery in hormone-resistant dysthyroid optic neuropathy.

Introduction: Tocilizumab (TCZ) has been demonstrated to be effective in treating thyroid-associated ophthalmopathy (TAO); however, its efficacy in hormone-resistant dysthyroid optic neuropathy (DON) remains unclear. This study aims to identify baseline and post-treatment indicators that can predict the necessity for surgical intervention following TCZ therapy.

Methods: Thirty-one hormone-resistant DON patients treated with TCZ were categorized into surgery (n=15, 7 males, 8 females) and non-surgery (n=16, 8 males, 8 females) groups based on their post-TCZ surgical status.

E-PL/MnO nanozymes/gellan gum/hyaluronic acid-based multifunctional hydrogel to promote diabetic wound healing.

The development of multifunctional hydrogels, especially hydrogels with antibacterial and antioxidant properties, plays a crucial role in the effective healing of diabetic wounds. This work proposed a novel composite hydrogel with the oxidized gellan gum (O-GG) and hyaluronic acid (HA) as the hydrogel matrix, and the crosslinking was realized via the Ca. ε-polylysine/MnO nanozymes (EM) offered antioxidant and antibacterial properties to the corresponding composite hydrogels.

Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses.

Chatbot-based multimodal AI holds promise for collecting medical histories and diagnosing ophthalmic diseases using textual and imaging data. This study developed and evaluated the ChatGPT-powered Intelligent Ophthalmic Multimodal Interactive Diagnostic System (IOMIDS) to enable patient self-diagnosis and self-triage. IOMIDS included a text model and three multimodal models (text + slit-lamp, text + smartphone, text + slit-lamp + smartphone).

Customizable hydrospongel based on chitosan microfibers.

Customizable and viscoelastic porous biomaterials are highly desired as implant scaffold for repairing large-volume defects. Herein, we report customizable chitosan microfibers (CMFs)-based hydrospongels with mechanical properties comparable to soft tissues. The CMFs formed under high-speed shearing during crystallization of chitosan, and then they are crosslinked through covalent bond and hydrogen bond to form hydrospongels.

Combined toxicity of polyethylene microplastics and nickel oxide nanoparticle on earthworm (Eisenia andrei): oxidative stress responses, bioavailability and joint effect.

The co-occurrence of heavy metals and microplastics (MPs) is an emerging issue that has attracted considerable attention. However, the interaction of nickel oxide nanoparticle (nano-NiO) combined with MPs in soil was poorly researched. Here, experiments were conducted to study the influence of nano-NiO (200 mg/kg) and polyethylene (PE) MPs with different concentrations (0.

Clinicopathological characteristics, local treatment, and prognostic factors in IE/IIE primary breast lymphoma: a retrospective study of 67 patients.

Introduction: Primary breast lymphoma (PBL) is a rare disease, treatment of which excerpts does not reach a consensus. This retrospective study was conducted to analyze clinical features and survival outcomes of different therapeutic methods.

Materials And Methods: Records of 67 patients with stage IE/IIE primary breast lymphoma were reviewed from the medical record system.

Toxicity of titanate nanotubes in earthworm (Eisenia fetida): Growth inhibition and integrated biomarker response.

Widely use of Titanate Nanotubes (TNTs) as remediation materials for heavy metal polluted water and soil lead to their release into the soil environment, persistently threatening faunal biodiversity and the entire environment. Growth inhibition rates (GIR) and specific growth rates (SGR) are used to evaluate the effect of TNTs on earthworm growth, and the integrated biomarker response (IBR) index is used to comprehensively evaluate the toxicity of eight biomarkers (Protein-body mass ratio, MDA, SOD, CAT, POD, Cellulase, AChE, and Na/K-ATPase) on earthworms exposed to TNTs contaminated soil by concentrations of CK, 50, 250, 500 and 2500 mg TNTs/kg dry soil. Results show that TNTs significantly inhibit the growth of earthworms (p < 0.

Effects of one-dimensional nanomaterial polyaniline nanorods on earthworm biomarkers and soil enzymes.

Polyaniline nanorods (PANRs) are typical one-dimensional nanomaterials (1D NMs), which are widely used in medicine, batteries and water treatment, etc. Applications of PANRs will eventually enter the soil environment, but their ecotoxicity has been barely reported. Therefore, we measured earthworm biomass, earthworm biomarkers and soil enzymes to investigate the ecotoxicity of PANRs.

Ecological improvement of antimony and cadmium contaminated soil by earthworm Eisenia fetida: Soil enzyme and microorganism diversity.

Vermiremediation on improvement of antimony (Sb) and cadmium (Cd) contaminated soil was less reported. In this study, earthworm Eisenia fetida was exposed into soil spiked with Sb and Cd and their mixture for 30 days, and then we measured multiple soil enzyme activities and bacteria communities via enzymatic reaction and high-throughput sequencing of 16 S rRNA genes. The results showed that Sb and Cd at high treatment levels inhibited the activities of urease, neutral phosphatase and protease significantly, but earthworm could promote the activities of urease and neutral phosphatase by 17.

Effect of multi-walled carbon nanotubes on extractability of Sb and Cd in contaminated soil.

The interaction between multi-walled carbon nanotubes (MWCNTs) and soil heavy metals was rarely studied. With the convenience of detecting multiple metal elements by ICP-AES, this paper examined the potential effectiveness of MWCNTs on extractability of antimony (Sb) and cadmium (Cd) in contaminated soil. Three-step sequential extraction procedure, toxicity characteristic leaching procedure, bioaccessibility and CaCl single extraction were employed to evaluate Sb and Cd speciations and their extractabilities.

Toxicity of soil antimony to earthworm Eisenia fetida (Savingy) before and after the aging process.

Information on soil antimony (Sb) toxicity to earthworm Eisenia fetida (Savingy) is limited. This ecotoxicology study was designed to quantify the soil Sb toxicity to earthworm E. fetida before and after aging process, establishing dose-effect relationship between Sb content and mortality.

A Rapid Method for Modeling a Variable Cycle Engine.

The variable cycle engines (VCE) that combine the advantages of turbofan and turbojet engines, are widely considered to be the next generation aircraft engines. However, developing VCE requires high costs. Thus, it is essential to build a mathematical model when developing an aircraft engine, which may avoid a large number of real tests and reduce the cost dramatically.