Pharmacotherapeutic potential of daidzein: insights into mechanisms and clinical relevance.

Daidzein, a soy-derived isoflavone, has gained significant attention due to its diverse pharmacological properties, including antioxidant, anti-inflammatory, and estrogenic activities. This review synthesizes current research on daidzein's biological effects, focusing on its role in chronic diseases, such as cancer, osteoporosis, cardiovascular disorders, and neurodegenerative conditions. Mechanistically, daidzein exerts its effects through estrogen receptor modulation, activation of antioxidant pathways, and regulation of inflammatory mediators.

Development and characterization of sodium tripolyphosphate-crosslinked Echinochloa esculenta (Ghingora) starch microspheres as potential drug carrier.

Starch, a naturally abundant polysaccharide, is widely utilized in various industries, including food, textiles and pharmaceuticals owing to its biocompatibility, biodegradability and versatility. In drug delivery systems, it functions as an excipient, binder and controlled-release agent. However, native starch has several limitations such as poor mechanical strength, low moisture retention and insufficient swelling capacity that restrict its application in advanced formulations.

A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy.

Reports of secondary malignancies after chimeric antigen receptor (CAR)-T and possible CAR-T derived malignant transformation necessitate caution. Here we describe a patient with diffuse large B-cell lymphoma who developed new lymphadenopathy 2.5 years after CAR-T in the context of COVID-19 infection with histopathologic features consistent with T-cell lymphoma (TCL).

β-Functionalized Push-Pull Monobenzoporphyrins: Synthesis, Photophysical, Structural Properties, and Electrocatalytic Hydrogen Evolution by Their Co(II) Complexes.

Hydrogen production through water splitting is a promising strategy toward sustainable energy, driving the need for efficient catalysts. This study presents a series of electronically tunable β-functionalized push-pull monobenzoporphyrins, MTPP(Benzo)(R) (R = CH, Ph, Bu-Ph, Py; M = 2H and Co(II)), and evaluates their cobalt(II) derivatives for the electrocatalytic hydrogen evolution reaction (HER). The successful synthesis of these compounds was confirmed through NMR, mass spectrometry, and UV-vis spectroscopy.

Polymorphic Phase-Dependent Vapor-Responsive Actuation in Silk Fibroin Films: Control of Bending Angle and Axis.

The composition of polymorphic phases, such as amorphous α-helices, crystalline β-sheets, and other secondary structures, in protein films plays a pivotal role in defining their physical, chemical, and mechanical properties. silk, which inherently possesses tunable secondary structures, can be easily tailored by processes such as mechanical stretching, water annealing, or exposure to specific solvents. In this work, we investigate the vapor-responsive actuation behavior of silk fibroin films fabricated via a nontoxic, aqueous-based processing route.

An aluminum-doped sodium manganese hexacyano ferrate cathode for high-rate safe Na-ion batteries.

Aluminum (Al) doping in sodium manganese hexa-cyano-ferrate (NMHCF) stabilizes the cubic phase and suppresses multiphase formation. Doping reduces the particle size (∼0.35 μm), catalyzing the rate kinetics.

Revisiting the Design of Sodiophilic Anodes to Accelerate the Development of High-Performance Sodium Batteries.

Sodiophilic anodes are pivotal for the development of high-performance sodium batteries. The sodiophilic character, necessary for a facile intercalation or plating of Na-ions, has not been given due attention and has never been discussed comprehensively. The present review highlights the importance of the sodiophilicity of the anodes and their effect on the performance of sodium batteries.

Hidden Cardiovascular Risk: Arterial Stiffness and Left Ventricular Remodeling as Potential Indicators of Masked Hypertension.

Masked hypertension (MH), characterized by normal office blood pressure (OBP) but elevated out-of-office readings, carries significant cardiovascular risks comparable to those of sustained hypertension, but remains difficult to detect in clinical practice. This review examines the emerging evidence on screening for MH, highlighting recent findings from the PAMELA study demonstrating the clinical utility of combined vascular and cardiac assessments for the detection of MH. Particularly noteworthy is the observation that patients with both an elevated cardiac-ankle vascular index (CAVI) and left ventricular hypertrophy (LVH) or concentric remodeling had a 2.

Molecular Engineering of MXene-Covalent-Triazine Framework Interfaces for Electrochemical Actuators.

Developing multifunctional nanomaterials for soft electrochemical actuators and energy storage devices is crucial for advancing next-generation soft robotics, wearable electronics, and bioinspired technologies. However, existing electrode materials face fundamental trade-offs among electronic conductivity, charge storage capacity, and ion transport efficiency. Here, we report a molecularly engineered hybrid nanoarchitecture that achieves the physicochemical stabilization of MXene terminals by the growth of 4-pyran functionalized, electronically conjugated covalent-triazine frameworks (MXene-CTF).

Malaria Presenting with Acute Respiratory Distress Syndrome: A Case Series.

traditionally considered a benign cause of malaria, is increasingly being recognized for causing severe complications, including acute respiratory distress syndrome (ARDS), renal dysfunction, and multiorgan dysfunction syndrome. This case series highlights the presentation and outcomes of ARDS associated with infection. This series reports five cases of malaria complicated by ARDS, admitted to the Department of Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, New Delhi.

GC-MS profiling and computational analysis of Balanites aegyptiaca phytoconstituents for antidiabetic activity: insights from network pharmacology and molecular docking.

This study investigates the antidiabetic potential of the extracts and subsequent phytochemicals of Balanites aegyptiaca (BA). The approaches used were GC-MS for phytochemical characterization, network pharmacology for target identification, in vitro studies, and computational techniques for the antidiabetic activity. Network pharmacology revealed genes-associated disease targets, i.

Comprehensive Genomic Profiling of Indian Patients With Lung Cancer.

Purpose: Genomic profiling has revolutionized non-small cell lung cancer (NSCLC) therapy, but molecular data on Indian patients with NSCLC are limited.

Materials And Methods: We analyzed next-generation sequencing (NGS) data of 5,219 Indian patients with lung cancer, tested between May 2022 and August 2023 at CORE Diagnostics, a commercial laboratory in India. Using the PulmoCORE gene panel, we targeted 13 key genes (, , , , , , , , , , , , and ) for DNA and RNA sequencing.

SnCl-mediated heterocyclization approach for the synthesis of benzisoxazole/quinoline-embedded β-carboline scaffolds.

A Sn(II)-mediated facile entry towards construction of C-C/C-O and C-C/C-N bonds was devised. The developed reductive heterocyclization method is described for the synthesis of a diverse range of novel β-carboline C-1- and C-3-linked vinyl benzisoxazole analogues from the corresponding 2-nitro chalcones. In addition, the synthesis of β-carboline C-1-substituted quinolines (Nitramarine analogues) was achieved.

Estimation of age using pulp/tooth area ratio using orthopantomographs and intra-oral periapical radiographs.

Teeth are crucial for assessing age, as they remain intact even after death in forensic dentistry. Various regression models, such as polynomial regression, new robust regression equations, multiple linear regression models and partial least squares linear regression, are used to determine age. The pulp/tooth area ratio (AR) of maxillary canines is a direct link between age and the subject's age, making multiple regressions the most reliable method.

Scalable spatial transcriptomics through computational array reconstruction.

Spatial transcriptomics enables gene expression mapping within tissues but is often limited by imaging constraints. We present an imaging-free approach that reconstructs spatial barcode locations using molecular diffusion and dimensionality reduction. Validated against ground truth imaging, our method achieves high fidelity and scales to centimeter-sized tissues.

Synthesis and Photophysical Characteristics of Samarium-based Complexes for Optoelectronic and Latent Fingerprint Applications.

In this study, five orange-red color samarium (Sm(III)) complexes were prepared using a solution precipitation method, with 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid as the primary ligand and nitrogen-donor like 1,10-phenanthroline, 2,2-biquinoline, neocuproine, and 2,2-bipyridyl as secondary ligands. The complexes were characterized using various spectral techniques, elemental analysis CHN, energy-dispersive X-ray spectroscopy (EDX), ultraviolet-visible (UV-vis), Fourier-transform infrared (FTIR), nuclear magnetic resonance (NMR) and thermal analyses by thermogravimetric analysis (TGA), differential thermal analysis (DTA). Photoluminescence spectroscopy revealed bright orange-red emissions due to the G → H transition at 605 nm in solid and 598 nm in solution, with color coordinates confirming their emission in the orange region.

Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.

Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, and metabolism. In Drosophila, an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock neurons called DN1. These DN1 neurons can further be subdivided into functionally and anatomically distinctive anterior (DN1a) and posterior (DN1p) clusters.

Radiation attenuation parameters and intrinsic efficiency of a few semiconductor crystals for radiation detection applications.

This study investigates the effectiveness of nine inorganic semiconductor crystals - LiGaSe, LiInSe, CsHgInS, SnS, GaTe, BiI, SbTe, TlCdI, and TlBr - for radiation detection applications based on photon and charged particle (electrons, protons, and heavy ions) interaction parameters. Mass attenuation coefficient (μ/ρ), half value layer (HVL), relaxation length (λ), effective atomic number (Z), electron density (N), equivalent atomic number (Z), and exposure buildup factor (EBF) were computed using PAGEX software. These results, along with their intrinsic efficiencies calculated, were compared with that of standard materials (NaI(Tl), CdZnTe, and CdTe).

Development of Mobile Application Based System for Improving Population Based Cancer Screening by Community Health Workers.

Objective: Cancer remains a leading cause of morbidity and mortality globally, with India experiencing a significant cancer burden. Effective population-based cancer screening is crucial for early detection and reduction of cancer-related deaths. This study aims to develop a mobile application-based Cancer Screening and Surveillance System (CSMS) to enhance the efficiency and effectiveness of population-based cancer screening by community health workers (CHWs).

Determinants of Improvement in Foot Bimalleolar Angle, Pirani Score, and Recurrence in Clubfoot Patients Treated With the Ponseti Technique.

Introduction: Foot bimalleolar angle (FBM angle) and Pirani score are recognized as assessment and prognostic tools for objective assessment of clubfoot (congenital talipes equinovarus, or CTEV) treatment. The present study proposed to study various factors that determine the improvement in FBM angle and Pirani score in patients treated by the Ponseti technique.

Materials And Methods: This prospective observational study was conducted after obtaining ethical clearance, and 42 children with CTEV (60 feet) were enrolled.

HRAMS Proteomics Insights on the Anti-Filarial Effect of : Implications in Phytochemical-Based Drug-Targeting and Designing.

Lymphatic filariasis (LF) continues to impact 657 million individuals worldwide, resulting in lifelong and chronic impairment. The prevalent anti-filarial medications-DEC, albendazole, and ivermectin-exhibit limited adulticidal efficacy. Despite ongoing LF eradication programs, novel therapeutic strategies are essential for effective control.

Novel pain assessment tool specific for pulp symptoms to aid diagnosis.

Aim: Although many pain assessment tools exist, none are specific to the relatively unique presentation of pulpal pain. The aim of this study was to develop and validate a novel pain assessment tool based on pulp symptoms.

Methodology: A preliminary list of items best-describing pulpitis was developed based on deductive and inductive approaches and the preliminary tool was piloted (n = 80).

Designing and comparative analysis of anti-oxidant and heat shock proteins based multi-epitopic filarial vaccines.

Background: Lymphatic Filariasis (LF) is a neglected tropical disease affecting more than 882 million people in 44 countries of the world. A multi-epitope prophylactic/therapeutic vaccination targeting filarial defense proteins would be invaluable to achieve the current LF elimination goal.

Method: Two groups of proteins, namely Anti-oxidant (AO) and Heat shock proteins (HSPs), have been implicated in the effective survival of the filarial parasites in their hosts.