Identification of a novel pathogen of the glacial relict Drosera rotundifolia and the impact of the fungus on the conservation of the plant and its habitat.

Round-leaved sundew (Drosera rotundifolia L.) is a protected glacial relict plant inhabiting Sphagnum bogs, which are endangered habitats in Hungary. In 2020 and 2021 greyish mycelium growth was observed on the hibernacula of D.

Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety.

An adverse gestational environment is a risk factor for the development of psychiatric disorders. Although studies have implicated modifications in neuronal DNA and chromatin, how these changes come about and lead to abnormal behaviors is not known. We sought to identify persistent DNA/chromatin and transcriptomic signatures induced by a proinflammatory gestational environment in the ventral dentate gyrus (vDG), a hippocampal region linked to anxiety.

Predicting infant vocabulary from neural connectivity and maternal speech: A machine learning approach.

Identifying early predictors of language development is essential for understanding how infants acquire vocabulary during the first years of life. While previous studies have established the importance of infant-directed speech (IDS) and neural speech processing, this longitudinal study introduces a novel approach by combining EEG-based functional connectivity analysis and machine learning to assess the joint contribution of maternal and infant neural factors to language outcomes. Data were collected at birth and nine months, including maternal personality and speech characteristics, alongside infant EEG responses during speech processing.

Ethical dimensions in nursing care for individuals with intellectual disabilities.

BackgroundIndividuals with intellectual and developmental disabilities (IDD) face significant health disparities, often exacerbated by ethical and legal complexities in nursing care. Nurses are frequently challenged to balance autonomy, informed consent, patient safety, and human rights, especially in settings with unclear guidelines or insufficient training. This narrative review explores the ethical and legal considerations in nursing care for individuals with IDD, aiming to highlight challenges and propose best practices.

Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO Cells.

Hepatitis C Virus (HCV) is a pervasive bloodborne virus and the leading cause of chronic liver disease and cancer. Thus, the development of an HCV vaccine is of great importance. Prior work has developed candidate vaccines, including more potent glycoengineered viral proteins and secreted forms of the E1E2 envelope heterodimer (sE1E2).

Assessing Professionalism in Dental Education: A Multi-Domain Approach across Classroom-Based, Preclinical, Clinical, and Remediation Curricula.

Professionalism is a cornerstone of dental education, encompassing the ethical principles, behaviors, and attitudes expected of dental practitioners. Its multifaceted nature manifests uniquely across various domains of the dental curriculum, including classroom-based, preclinical, clinical, and remediation settings. Effectively assessing professionalism within these diverse contexts presents significant challenges, necessitating a structured, multi-contextual assessment approach.

Patterns of Childhood Maltreatment and Intimate Partner Violence: Associations with Prenatal Depression and Anxiety.

Purpose: Childhood maltreatment (CM) and intimate partner violence (IPV) are two deleterious relational experiences that have significant negative consequences during the prenatal period. The current study had two aims: a) use person-centered analyses to identify classes of pregnant individuals based on exposure to different types of CM and IPV and b) examine the associations between patterns of CM, IPV, prenatal anxiety and prenatal depression symptoms.

Methods: Participants were a majority Black sample of 222 pregnant individuals who completed self-report measures of CM, IPV in the last year, depression and anxiety.

High-density lipoproteins. Part 2. Impact of disease states on functionality.

In contrast to low-density lipoproteins which are atherogenic, high-density lipoproteins (HDL) have been conceptualized as beneficial modulators of adverse pathophysiological phenomena along arterial walls. The HDLs are characterized by highly complex and varied molecular cargoes that include apoproteins, enzymes, microRNAs, bioactive lipids and phospholipids, components of complement, and immune factors, among others. These cargo components determine its functionality.

Detection of Anti-IFNγ Autoantibodies From Dried Blood Spots.

Background: High titer, neutralizing anti-cytokine autoantibodies (ACAA) to interferon gamma (IFNγ) are an emerging cause of adult-onset immunodeficiency, and detection can direct clinical management. Currently, the detection of ACAAs is performed on blood or plasma, which is time-sensitive, relatively expensive to obtain, and must be shipped from remote locations in specialized containers. We have adapted an easier method of collecting blood or plasma onto a paper card as dried blood spots (DBS), which is simple, inexpensive, and does not require a medical facility or special mailing.

Direct aspiration versus stent retriever as First-line thrombectomy techniques for acute Basilar artery occlusions: an updated systematic review and Meta-Analysis.

Background: Endovascular thrombectomy is the primary treatment for acute basilar artery occlusion (BAO), with direct aspiration (DA) and stent retriever (SR) as the main techniques. This updated meta-analysis aims to compare these two techniques in terms of efficacy and safety outcomes.

Methods: A search was performed across PubMed, Embase, and Cochrane databases on December 23, 2024.

Results of a pilot randomized controlled trial of Tuning in to Kids for children with FASD in nonbiological parent care.

Background: Emotion regulation difficulties and placements with nonbiological parents are common in children with fetal alcohol spectrum disorders (FASD). We tested whether the Tuning in to Kids (TIK) intervention would improve emotion regulation in children with FASD living with nonbiological parents by targeting caregiver emotion socialization.

Method: A two-arm pilot randomized controlled trial of the 8-week, group-based TIK program was conducted from 8/2017 to 9/2021 (ClinicalTrials.

Chlorophyll-mediated in vivo and in vitro photoisomerization of ζ-carotene and lycopene in Synechocystis PCC 6803.

Carotenoid biosynthesis in photosynthetic organisms involves converting cis-isomers to trans forms through enzymatic and light-induced reactions. While enzymatic pathways are well-documented, the role of light, particularly chlorophyll-mediated sensitization, remains unclear. This gap in understanding complicates efforts to optimize carotenoid production and fully grasp the evolutionary interplay between enzymatic and light-driven processes.

Characterization of a Thermostable α-Amylase from 104.K for Industrial Applications.

This study describes the characterization of a novel thermostable α-amylase from a 104.K strain isolated from the Kashkadarya region of Uzbekistan. Phylogenetic analysis revealed that the thermostable α-amylase belongs to glycoside hydrolase family 13 subfamily 5 (GH13_5) and shares high sequence similarity with known α-amylases.

Fabrication and Evaluation of Isomalt-Based Microfibers as Drug Carrier Systems.

: The melt-spinning process has seen limited application in the pharmaceutical industry. However, nano- and microfibrous structures show significant potential for novel drug delivery systems, due to their high specific surface area. To facilitate broader adoption in pharmaceutical technology, critical parameters influencing fiber quality and yield must be investigated.

Sex Differences in Cardiovascular Risk and Diabetic Polyneuropathy: A Single-Center Retrospective Study in North-Eastern Hungary.

: Diabetic sensorimotor polyneuropathy (DSPN) is a frequent microvascular complication of diabetes mellitus, associated with increased morbidity and reduced quality of life. The existing literature offers a limited understanding of sex-specific cardiovascular risk profiles and their association with DSPN, particularly within Central and Eastern European populations. : A retrospective analysis was conducted using data from 621 individuals with type 1 or type 2 diabetes mellitus who underwent comprehensive neuropathy screening at the University of Debrecen between 2017 and 2021.

TARPγ2-Derived Peptide Enhances Early-Phase Long-Term Potentiation and Impairs Memory Retention in Male Rats.

: Disruption of AMPAR trafficking at excitatory synapses contributes to impaired synaptic plasticity and memory formation in several neurological and psychiatric disorders. Arc, an immediate early gene product, has been shown to interact with the AMPAR auxiliary subunit TARPγ2, affecting receptor mobility and synaptic stabilization. : To investigate the in vivo functional effects and protein interactions of the Arc-TARPγ2 interfering peptide RIPSYR, we performed in vivo electrophysiology and spatial memory assessments in male rats.

Outcome of a FODMAP restriction diet with subsequent blinded reintroduction in functional dyspepsia/postprandial distress syndrome.

Background: Recent studies have shown increased duodenal mucosal permeability as a possible key player in the pathophysiology of functional dyspepsia (FD). Adverse reaction to nutrients is an important candidate underlying mechanism. Intragastric infusion of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) induced symptoms reminiscent of FD with a rapid onset.

Cold Tolerance Differences Between Declining Native and Invasive Bumblebees in Patagonia.

Temperature is a key environmental factor influencing the establishment and spread of insect species. Differences in thermal tolerance may thus explain patterns of geographical distribution and dominance during biological invasions. The native Patagonian bumblebee, Bombus dahlbomii, is being displaced by the exotic Bombus terrestris, which has expanded throughout its range.

Pigment epithelium detachment with thickened choroid in a preterm infant at term-equivalent age: a case report.

Pigment epithelial detachment (PED) is well-documented in adult retinal diseases but is rarely reported in neonates. This case describes a preterm infant, born at 31 weeks, who developed PED with thickened choroid at term-equivalent age, detected using handheld OCT. The PED emerged at 39 weeks postmenstrual age, coinciding with inhaled steroid treatment for respiratory distress, and resolved by 41 weeks after steroid discontinuation without structural damage.

Radon exhalation rate and emanation factor values in relation to different soil characteristics.

The natural background radiation to humans comes both from outside the Earth (cosmic radiation) and from radioactive isotopes found on Earth (terrestrial radiation). Radionuclides of terrestrial origin are partly external exposure and partly internal exposure via ingestion and inhalation. One of the most important sources of external terrestrial radiation is soil, where the most significant isotopes found are uranium-238, uranium-235 and thorium-232, members of the decay series, and potassium-40.

Gold Nanoparticles Disrupt Mitochondrial Activity in Hypothalamic POMC Cells: Implications for Energy Homeostasis.

Gold nanoparticles (AuNPs) have several beneficial properties that make them effective as intracellular drug carriers, and their potential for various diagnostic and therapeutic applications is gaining recognition. Depending on their size and shape, AuNPs can cross the central nervous system (CNS) through the blood-brain barrier (BBB). In the CNS, they can exert a variety of influences on neuronal and glial cells, which can be both supportive-promoting cell health and function-and cytotoxic, potentially leading to cellular damage.

Heart Rate Variability Alterations During Delayed-Onset Muscle Soreness-Inducing Exercise-With Piezo2 Interpretation.

Heart rate variability (HRV) is often modulated by pain; therefore, the objective of this study was to assess whether the induction of delayed-onset muscle soreness (DOMS) is already affected by HRV alterations during exercise, in spite of the fact that pain evolves only post-exercise. An isokinetic dynamometer was used to induce DOMS in this study on 19 young male elite handball players who were subjected to HRV measurements throughout a DOMS-inducing exercise session. The result of this study indicated that the heart rate (HR) dependence of time-frequency domain parameters could be described by an exponential-like function, while entropy showed a V-shaped function, with a minimum "turning point" separated by descending and ascending intervals.

Relationship Between GPS-Derived Variables and Subjective Questionnaires Among Elite Youth Soccer Players.

The aim of this study was to examine the relationship between the external load (EL) and internal load among U15, U17, and U19 youth soccer players and to identify the factors best influencing the rating of perceived exertion (RPE) and session-RPE (s-RPE) from Global Positioning System-derived variables. Data were collected from 50 male youth soccer players over an 11-week in-season period, encompassing a total of 1386 observations (145 training sessions and 33 matches). The findings indicate that during training sessions, the relationship between EL-derived volume variables and s-RPE exhibited moderate-to-very-strong correlations (U15-r ranging from 0.

Overexpression of the human heat shock protein B1 alters obesity-related metabolic changes in a sex-dependent manner in a mouse model of metabolic syndrome.

Background: Obesity is a global health challenge that can lead to various complications, such as metabolic syndrome, diabetes mellitus, and cardiovascular diseases. Heat shock proteins are evolutionarily conserved chaperones that help maintain cellular protein homeostasis. Their expression is dysregulated in various chronic diseases, including diabetes mellitus and hyperlipidemia, and they also regulate inflammatory processes.