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Pigment epithelial detachment (PED) is well-documented in adult retinal diseases but is rarely reported in neonates. This case describes a preterm infant, born at 31 weeks, who developed PED with thickened choroid at term-equivalent age, detected using handheld OCT. The PED emerged at 39 weeks postmenstrual age, coinciding with inhaled steroid treatment for respiratory distress, and resolved by 41 weeks after steroid discontinuation without structural damage. The temporal relationship suggests an association between steroid use and PED with choroidal changes. This case highlights the value of OCT in detecting retinal and choroidal abnormalities in preterm infants and underscores the potential impact of systemic conditions and medications on the choroid.
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http://dx.doi.org/10.3389/fmed.2025.1581191 | DOI Listing |
Aging Dis
August 2025
Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
The choroid plexus (ChP), a highly vascularized brain structure responsible for cerebrospinal fluid (CSF) production, undergoes significant age-related changes that may contribute to neurodegenerative diseases involving disrupted immune regulation, fluid homeostasis and waste clearance. Compared to other brain regions, vascular research on the ChP remains limited despite its critical role as a central interface between the blood and CSF. This review focuses on age-related vascular and structural alterations in the ChP from both histopathological and neuroimaging perspectives, and explores their impact on CSF dynamics, immune regulation, and the integrity of the blood-CSF barrier (BCSFB).
View Article and Find Full Text PDFBMC Ophthalmol
August 2025
Department of Ophthalmology, Peking University First Hospital, Beijing, China.
Background: Sturge-Weber syndrome (SWS) is a rare congenital phacomatosis disorder. choroidal hemangioma (CH) is one of the most common ocular manifestations. The advancements in swept-source optical coherence tomography angiography (SS-OCTA) provide us a comprehensive view of the CH.
View Article and Find Full Text PDFBiomolecules
July 2025
AltRegen Co., Ltd., 1201, Byoksan Digital Valley 5-cha, Beotkkot-ro, Seoul 08513, Republic of Korea.
The extracellular matrix (ECM) is a collagen-based scaffold that provides structural support and regulates nutrient transport and cell signaling. ECM homeostasis depends on a dynamic balance between synthesis and degradation, the latter being primarily mediated by matrix metalloproteinases (MMPs). These enzymes are secreted as pro-forms and require activation to degrade ECM components.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, United States.
Pigment epithelial detachment (PED) is well-documented in adult retinal diseases but is rarely reported in neonates. This case describes a preterm infant, born at 31 weeks, who developed PED with thickened choroid at term-equivalent age, detected using handheld OCT. The PED emerged at 39 weeks postmenstrual age, coinciding with inhaled steroid treatment for respiratory distress, and resolved by 41 weeks after steroid discontinuation without structural damage.
View Article and Find Full Text PDFBMC Ophthalmol
August 2025
B.P. Eye Foundation, Children's Hospital for Eye, ENT and Rehabilitation Services, Bhaktapur, Nepal.
Purpose: Seasonal Hyperacute Panuveitis (SHAPU) is a severe, rapid-onset panuveitis primarily affecting children, often linked to the setae released in the air or by contact with female moths of the genus Gazalina (Lepidoptera, Notodontidae), or with their egg masses laid on various substrates. This study aims to report a rare case of SHAPU from the higher altitude of Nepal with an alpine climate, with concurrence of necrotising scleritis. To the best of our knowledge, this is the first report of SHAPU at high elevation.
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