Predicting infant vocabulary from neural connectivity and maternal speech: A machine learning approach.

Identifying early predictors of language development is essential for understanding how infants acquire vocabulary during the first years of life. While previous studies have established the importance of infant-directed speech (IDS) and neural speech processing, this longitudinal study introduces a novel approach by combining EEG-based functional connectivity analysis and machine learning to assess the joint contribution of maternal and infant neural factors to language outcomes. Data were collected at birth and nine months, including maternal personality and speech characteristics, alongside infant EEG responses during speech processing.

Corrigendum: The influence of temperament and perinatal factors on language development: a longitudinal study.

[This corrects the article DOI: 10.3389/fpsyg.2024.

The influence of temperament and perinatal factors on language development: a longitudinal study.

Early language development is characterized by large individual variation. Several factors were proposed to contribute to individual pathways of language acquisition in infancy and childhood. One of the biologically based explaining factors is temperament, however, the exact contributions and the timing of the effects merits further research.

Psychometric properties of the Hungarian childhood trauma questionnaire short form and its validity in patients with adult attention-deficit hyperactivity disorder or borderline personality disorder.

Background: Compelling evidence supports the role of childhood traumatization in the etiology of psychiatric disorders, including adult attention-deficit hyperactivity disorder (aADHD) and borderline personality disorder (BPD). The aim of this study was to examine the psychometric properties of the Hungarian version of the Childhood Trauma Questionnaire Short Form (H-CTQ-SF) and to investigate the differences between patients diagnosed with aADHD and BPD in terms of early traumatization.

Methods: Altogether 765 (mean age = 32.

Differential Genetic Effect of the Norepinephrine Transporter Promoter Polymorphisms on Attention Problems in Clinical and Non-clinical Samples.

Among the monoaminergic modulatory neurotransmitters, norepinephrine is involved in task orienting, hence noradrenergic genetic variants have been studied in connection to attentional processes. The role of this catecholamine system is also highlighted by the selective norepinephrine transporter blocking atomoxetine, which has proved to be effective in the pharmacological treatment of Attention Deficit Hyperactivity Disorder (ADHD). In the present genetic association study three single nucleotide polymorphisms (rs28386840, rs2242446, rs3785143 SNPs) were analyzed from the 5' region of the norepinephrine transporter (, ) gene, which have been linked to ADHD previously.

A pilot study of early onset obsessive-compulsive disorder: Symptom dimensions and association analysis with polymorphisms of the serotonin transporter gene.

Our aim was to introduce more homogenous phenotypes for studying genetic variations in the clinically heterogeneous obsessive compulsive disorder (OCD) beside classical case-control analysis. Symptoms were assessed with Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and principle component analysis of the lifetime symptom categories yielded four factors (Cleaning, Obsessive, Compulsive, Sexual). The comparison of serotonin transporter linked polymorphic region (5-HTTLPR) in 102 OCD patients and 223 controls showed an increased L-allele frequency but no difference was observed when rs25531 was included.

Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.

Aims: Methylphenidate (MPH) is the most frequently prescribed drug in Attention Deficit Hyperactivity Disorder (ADHD). Hitherto mostly the dopamine transporter gene has been studied in MPH-response and only a few studies analyzed the norepinephrine transporter (NET, SLC6A2) gene, although MPH is a potent inhibitor of both dopamine and norepinephrine transporters. We aimed to analyze this monoamine transporter gene in relation to ADHD per se and MPH-response in particular to gain further knowledge in ADHD pharmacogenetics using a Caucasian sample.

[Screening childhood behavior problems using short questionnaires II.: The Hungarian version of the SWAN-scale (Strength and Weakness of ADHD-symptoms and Normal-behavior) for screening attention deficit/hyperactivity disorder].

Introduction: The SWAN (Strength and Weakness of ADHD-symptoms and Normal-behavior) Questionnaire is a short instrument suitable for screening attention deficit/hyperactivity disorder. Its completion by parents or teachers requires a few minutes. Positive re-wording of attention- and activity-related behaviors and the extended 7- point rating scale anchored to average behavior make the instrument especially suitable for normal populations.

Brain activity during emotion perception: the role of attachment representation.

To examine emotional face processing in mothers of different attachment representations, event-related potentials were recorded from 16 mothers during presentation of infant emotion faces with positive, negative or neutral emotional expressions within a three-stimulus oddball paradigm, and frontal asymmetries were assessed. Insecure mothers, as compared to secure ones, showed a more pronounced negativity in the face-sensitive N170 component and a smaller N200 amplitude. Regarding the P300 component, secure mothers showed a stronger response to face stimuli than insecure mothers.

[Screening childhood behavior problems using short questionnaires I.: the Hungarian version of the Strengths and Difficulties Questionnaire].

Introduction: The Strengths and Difficulties Questionnaire (SDQ) is a short questionnaire suitable for screening childhood behavior problems. Completing the questionnaire requires 5 minutes of parents' or teachers' time. The scales of the original version showed good agreement with relevant scales of the much longer Child Behavior Checklist (CBCL).

Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children.

Methylphenidate is the most frequently prescribed drug in the treatment of attention deficit hyperactivity disorder (ADHD) but it is not effective in every case. Therefore, identifying genetic and/or biological markers predicting drug-response is increasingly important. Here we present a case-control study and pharmacogenetic association analyses in ADHD investigating three dopaminergic polymorphisms.

Infant genotype may moderate sensitivity to maternal affective communications: attachment disorganization, quality of care, and the DRD4 polymorphism.

Disorganized attachment is an early predictor of the development of psychopathology in childhood and adolescence. Lyons-Ruth et al. (1999) developed the AMBIANCE coding scheme to assess disrupted communication between mother and infant, and reported the link between maternal behavior and disorganized attachment.

Association between dopamine D4 receptor (DRD4) gene polymorphisms and novelty-elicited auditory event-related potentials in preschool children.

We investigated associations of the exon III repeat and the -521 C/T polymorphisms of the DRD4 gene with novelty-elicited auditory ERP components and behavioral resistance to distraction in 57 healthy, typically developing 6-year-old children. Dopamine-related gene polymorphisms have previously been linked to processes directing focused attention. We did not find associations between the 7-repeat allele or the T.

[Effects of the D4 dopamine receptor gene variation on behavior problems at 6 years of age].

Association of the 7-repeat allele of the D4 dopamine receptor (DRD4) exon 3 polymorphism with attention deficit/hyperactivity disorder is well-established, and a link with mother-reported aggressiveness was also found in healthy pre-schoolers assessed by the quantitative scale of the Child Behavior Checklist. In the present study, we hypothesized that children carrying the 7-repeat allele would show more attention problems and externalizing (aggressive and delinquent) behavior at 6 years of age. Further, we hypothesized a potential mediating role of early temperament in the relationship of DRD4 gene with behavior problems.

Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment.

Following up the results of a previous population association study (Lakatos et al. [2000: Mol Psychiatry 5:633-637; Lakatos et al. [2002: Mol Psychiatry 7:27-31]) by analyses based on parental genetic data confirmed the link between infant attachment and the dopamine D4 receptor (DRD4) gene.