Publications by authors named "Thomas Gary"
The impact of statins on pulmonary embolism severity-a retrospective data analysis.
Res Pract Thromb Haemost
July 2025
Background: Recent studies have demonstrated decreased rates of venous thrombotic events, including pulmonary embolism (PE), in patients taking statins. It, however, remains elusive whether statins could also impact PE severity.
Objectives: To investigate a potential association between statin use and the severity of PE in a retrospective cohort.
Patients with primary brain tumors have a high risk of venous thromboembolism (VTE). This study aims to estimate the prevalence of asymptomatic VTE and to identify risk factors and biomarkers for asymptomatic VTE in patients with brain tumors by screening for asymptomatic LE-DVT. Fifty patients were included in the study.
View Article and Find Full Text PDFEvaluating the predictive role of endothelial dysfunction in the development of vasculopathy-mediated complications in patients with limited cutaneous systemic sclerosis (lcSSc). 38 patients with lcSSc who were naïve for vasculopathy-mediated complications, defined as absent pre-existing digital ulcers (DU), pulmonary hypertension (PH) and symptomatic atherosclerotic cardiovascular diseases, were prospectively observed during a 3-years follow-up period. At study enrolment, functional and laboratory parameters of endothelial dysfunction were assessed.
View Article and Find Full Text PDFCritical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk stratification in patients with lower extremity artery disease (LEAD). For this cross-sectional retrospective analysis, 21712 patients with LEAD were screened for eligibility from 2004 to 2020.
View Article and Find Full Text PDFExploring the relationships of physical, mental, and emotional symptoms and serum biomarkers of angiogenesis in multiple sclerosis.
Mult Scler J Exp Transl Clin
April 2025
Background: Multiple sclerosis (MS) involves symptoms that may be impacted by angiogenesis. Vascular endothelial growth factor (VEGF), a potent pro-angiogenic molecule, is elevated in early MS, but its activity in later disease is understudied. [Met]-enkephalin (ENK) has anti-angiogenic activity and is decreased in persons with MS (PwMS).
View Article and Find Full Text PDFThe new guidelines for the management of peripheral arterial and aortic diseases (PAAD) from the European Society of Cardiology and endorsed by the European Society of Vascular Medicine (ESVM), emphasize on a comprehensive and multidisciplinary approach focusing on prevention, diagnosis, treatment, and follow-up of patients with a wide range of PAAD, including lower extremity peripheral arterial disease (PAD). The aim of this summary, focusing on PAD and coordinated by the Young Academy of ESVM, is to provide young angiologists with the fundamental principles of these guidelines and to assist them in navigating their everyday clinical practice. PAD diagnosis relies on objective evaluation of flow/oxygen reduction at rest, with arterial ultrasound as the first imaging modality to confirm the presence of arterial lesions.
View Article and Find Full Text PDFBackground: The Vienna Prediction Model (VPM) identifies patients with a first unprovoked deep vein thrombosis of the leg and/or pulmonary embolism who have a low recurrence risk and may, therefore, not benefit from extended-phase anticoagulation.
Objectives: The aim of this study was to evaluate patients with a predicted high risk of recurrent venous thromboembolism (VTE).
Methods And Results: We prospectively followed 266 patients in whom the VPM had predicted a recurrence risk of more than 5.
Article Synopsis
- - The study examined the potential impact of lipoprotein (a) [Lp(a)] on the severity of venous thromboembolic events in pulmonary embolism (PE) by analyzing 90 patients and their Lp(a) levels.
- - Results indicated that Lp(a) levels did not correlate with the thrombus load or location in PE, suggesting it may not significantly influence the extent of venous thromboembolism.
- - The study found a strong correlation between thrombus load and D-dimer levels, as well as the right to left ventricular diameter ratio, implying these factors might be more relevant in assessing PE severity.
Article Synopsis
- - The regulation of SIRT1 is crucial for maintaining energy balance and is involved in various diseases, particularly how insulin interacts with it through DBC1 and PACS-2 to inhibit activity.
- - Research reveals that the DBC1/PACS-2 complex in the liver manages SIRT1's daily activity, essential for switching fuel use from fat to glucose in response to insulin.
- - Acetylation and phosphorylation of specific amino acids in DBC1 and SIRT1 affect their interaction, with implications for diseases like obesity and fatty liver disease if the regulatory pathway fails.
Article Synopsis
- * Research reveals that the mutated PACS1 protein enhances its interaction with HDAC6, an enzyme, leading to reduced acetylation of certain neuronal proteins and negatively impacting neuron structure and function.
- * Treatment with targeting agents for PACS1 or HDAC6 shows promise in restoring normal neuronal features and improving synaptic transmission in affected brain areas, suggesting a potential therapeutic approach for PACS1 syndrome.
Heparin regimes in head and neck cancer flap surgery: A retrospective cohort study of free flap complications graded by Clavien-Dindo.
J Craniomaxillofac Surg
October 2023
Article Synopsis
- - The study compared low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) protocols in patients undergoing free flap reconstruction for head and neck squamous cell carcinoma (HNSCC) from 2010 to 2022.
- - A total of 116 patients were analyzed, with most experiencing only minor complications, and similar rates of flap loss observed in both groups.
- - The findings indicate that UFH is equally safe and effective as LMWH for postoperative outcomes in this patient population; free flap surgery is confirmed to be a viable option for reconstruction.
Article Synopsis
- The study evaluates the Vienna Prediction Model (VPM) to identify patients with unprovoked venous thromboembolism (VTE) who are at low risk of recurrence after stopping anticoagulation treatment.
- Among 818 patients, 520 had a predicted recurrence risk of ≤5.5%, with actual recurrence rates being 5.2% after 1 year and 11.2% after 2 years.
- The VPM was found to underestimate recurrence risk in some cases, but recalibration improved its accuracy in identifying low-risk patients, with men showing higher recurrence rates than women.
Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca dynamics linked to DEE66.
Proc Natl Acad Sci U S A
August 2023
Article Synopsis
- The endoplasmic reticulum (ER) and mitochondria interact to create mitochondria-associated ER membranes (MAMs), which are crucial for calcium (Ca) balance in neurons.
- Casein kinase 2 alpha 1 (CK2A1) plays a key role in regulating the structure and Ca transport of MAMs through its effect on PACS2 phosphorylation.
- Mutations in PACS2 linked to a specific form of epilepsy disrupt MAM integrity and disturb Ca transport, leading to increased cytosolic Ca levels and enhanced neurotransmitter release in certain brain neurons.
Article Synopsis
- PACS1-neurodevelopmental disorder (PACS1-NDD) is linked to a specific genetic variation, Arg203, which causes a type of intellectual disability due to its effect on PACS1 protein's client protein interactions.
- Researchers hypothesize that other PACS1 variants that disrupt binding to adaptor proteins could also lead to similar intellectual disabilities.
- A novel PACS1 variant (Ser252Phe) was identified in a mother-daughter pair, which may impair binding to an adaptor protein (GGA3), suggesting it could contribute to PACS1-NDD-like symptoms and enhancing understanding of how PACS1 variations cause intellectual disabilities.
Article Synopsis
- * A significant genetic factor is the PACS1 gene, where a specific mutation is associated with developmental delays and intellectual disabilities, but the mechanisms through which this occurs are not fully understood.
- * Research indicates that PACS1 interacts with the protein HDAC6, affecting the regulation of neuron structure and functioning; treatments targeting these proteins show promise in restoring normal neuronal function in models of PACS1 syndrome.
Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic.
Int Immunopharmacol
December 2022
Article Synopsis
- * A study in central Pennsylvania investigated the effects of low-dose naltrexone (LDN) on anxiety and depression in PwMS during the early months of COVID-19.
- * Results showed that PwMS on LDN reported significantly lower anxiety and depression scores compared to those on standard oral disease-modifying therapies, indicating LDN may be a helpful treatment option.
Article Synopsis
- * Three weeks later, he experienced bilateral central pulmonary embolism, leading to cardiac arrest and the need for veno-arterial extracorporeal membrane oxygenation (VA-ECMO).
- * Following endovascular thrombectomy using an Aspirex device, his condition improved, allowing for VA-ECMO to be discontinued after a day, and he was later discharged from ICU after 15 days; the case highlights alternative rescue strategies for patients who can't receive thrombolysis.
Article Synopsis
- COVID-19 vaccines were rapidly developed following the pandemic's onset, with cases of unusual thrombotic complications appearing soon after, particularly with adenoviral vector vaccines like those from AstraZeneca and Johnson & Johnson.
- These complications, known as vaccine-induced thrombotic thrombocytopenia (VITT), involve rare thrombotic events paired with low platelet counts and share similarities with heparin-induced thrombocytopenia (HIT).
- The review focuses on providing an overview of how to diagnose and treat these complications, noting that standard treatment for other thrombotic events may be harmful in these cases.
The Path to Therapeutic Furin Inhibitors: From Yeast Pheromones to SARS-CoV-2.
Int J Mol Sci
March 2022
Article Synopsis
- * Key research from various fields, including endocrinology and virology, led to the discovery of furin and laid the groundwork for developing furin inhibitors that target disease pathways linked to multiple health conditions.
- * The review highlights historical studies that ultimately guide current efforts to create small-molecule furin inhibitors, aiming to combat COVID-19 and other diseases dependent on furin for their harmful effects.
Lipoprotein(a) and Pulmonary Embolism Severity-A Retrospective Data Analysis.
Front Cardiovasc Med
February 2022
Article Synopsis
- The study aimed to explore the relationship between the severity of pulmonary embolism (PE) and levels of lipoprotein (a) [Lp(a)] in patients at the University Hospital Graz, Austria.
- A retrospective analysis of 811 PE patients was conducted, categorizing them into four risk groups based on the 2019 ESC guidelines: low risk, intermediate low risk, intermediate high risk, and high risk.
- The research found no significant correlation between PE severity and Lp(a) levels, as similar median Lp(a) concentrations were observed across all risk groups.
Article Synopsis
- * Results indicated that while men generally experienced higher intraoperative blood loss (IOB) and perioperative bleeding volume (CBL-48 hours) compared to women, only CBL-48 showed significant statistical differences.
- * Understanding these gender differences in blood loss can assist clinicians in predicting and managing excessive bleeding during orthognathic surgical procedures.
Article Synopsis
- Rab32 is a small GTPase that plays a crucial role in targeting organelles, particularly at ER-mitochondria contact sites, and influencing mitochondrial membrane dynamics.
- The study identified specific MERC proteins, such as TMX1, that are targeted for degradation through Rab32-mediated autophagy, revealing RTN3L as an important effector in this process.
- The authors introduce the term "MAM-phagy" to describe this selective autophagy that degrades mitochondrial-proximal ER membranes, highlighting Rab32's role in regulating cellular degradation pathways.
Article Synopsis
- Cerebral venous thrombosis (CVT) is linked to multiple risk factors, including thyroid dysfunction, specifically hyperthyroidism, but systematic research on this connection has been limited.
- In a study of 120 CVT patients at a single center from 2006 to 2020, 107 patients had their thyroid-stimulating hormone (TSH) levels checked, revealing that 17.8% had thyroid dysfunction, primarily hypothyroidism.
- The findings suggest a high prevalence of thyroid issues among CVT patients and indicate the need for further research to determine any causal relationship, while also recommending TSH screening for these patients.
Article Synopsis
- A multicenter study was conducted to assess the risk of venous (VTE) and arterial thromboembolism (ATE) in patients with advanced pancreatic cancer (aPC) receiving palliative chemotherapy.
- Of the 455 patients studied, a significant number experienced VTE (20%) and ATE (2.8%), with VTE leading to increased mortality and cancer progression.
- The findings highlighted that a prior history of VTE significantly raised the risk for VTE, while cerebrovascular disease notably increased ATE risk; however, existing prediction models were not effective in identifying these risks in this patient population.