Publications by authors named "Takanobu Yamada"
Background: Gastric neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy for which no standard treatment has been established for locoregional disease. This multicenter retrospective study aimed to evaluate the prognostic relevance and therapeutic efficacy of lymph node dissection in this setting.
Methods: A total of 118 patients with gastric NEC or mixed adenoneuroendocrine carcinoma (MANEC) who underwent gastrectomy with lymph node dissection were analyzed.
Background/aim: The clinical evaluation of the GNRI in nutritional status management has been reported in several malignancies. This study aimed to investigate the relationship between the GNRI and clinical outcomes in postoperative patients who underwent radical gastrectomy.
Patients And Methods: Clinical data of 940 gastric cancer patients who underwent radical gastrectomy at Kanagawa Cancer Center from 2013 to 2020 were retrospectively collected and divided into a high-GNRI group (≥98) and a low-GNRI group (<98) according to the GNRI.
Background: Fulminant myocarditis is life-threatening and often requires mechanical circulatory support. Predicting its clinical course is crucial, yet data on early recovery predictors, particularly with veno-arterial extracorporeal membrane oxygenation, remain lacking.
Methods And Results: We aimed to identify prognostic factors of early recovery in fulminant myocarditis requiring veno-arterial extracorporeal membrane oxygenation by retrospective analysis of a nationwide registry in Japan.
Background: Original apical hypertrophic cardiomyopathy was characterized by left ventricular hypertrophy confined to the apex below the papillary muscle level. In contrast, apical hypertrophic cardiomyopathy in Western countries often includes hypertrophy extending to the midventricular septum. Recognizing these phenotypic differences is essential as they may influence the clinical prognosis.
View Article and Find Full Text PDFBackground/aim: Neoadjuvant chemotherapy is gaining recognition for its potential to improve survival outcomes, with combined neoadjuvant and adjuvant therapies under investigation. However, the prognostic significance of post-chemotherapy pathological staging (ypStage) on recurrence-free survival (RFS) remains unclear. This study aimed to evaluate the utility of ypStage, ypT, ypN classification, and histological response rate in predicting recurrence after gastrectomy.
View Article and Find Full Text PDFThe omentum is a common site of peritoneal metastasis in various cancers, including gastric cancer. It contains immune cell aggregates known as milky spots, which provide a microenvironment for peritoneal immunity by regulating innate and adaptive immune responses. In this study, we investigated gene expression profiles in cells from omental milky spots of patients with gastric cancer (n = 37) by RNA sequencing analysis and classified the patients into four groups (G1-4).
View Article and Find Full Text PDFIntroduction: Laparoscopic distal gastrectomy (LDG) is the standard treatment for gastric cancer, during which the laparoscopic Billroth I anastomosis technique, also known as the delta-shaped anastomosis (DA), is widely performed. This study aimed to evaluate the differences in short- and long-term symptoms between DA and traditional circular anastomosis (CA) techniques.
Methods: We retrospectively compared DA and CA procedures in patients undergoing LDG and subsequent reconstruction using the Billroth I method at the Kanagawa Cancer Center from 2017 to 2022.
Background: Identifying the most effective postoperative surveillance interval in patients with gastric cancer (GC) remains challenging. To elucidate a logical and effective surveillance schedule, we analyzed GC recurrence risk trends after gastrectomy using the hazard function.
Methods: We retrospectively reviewed the medical records of 2503 patients who underwent curative GC resection between 2000 and 2018.
Article Synopsis
- The study examines how short-term changes in skeletal muscle and adipose tissue after surgery affect survival and recurrence in gastric cancer patients.
- Patients were analyzed before and one month after surgery, categorizing them based on levels of muscle and fat loss.
- Results indicated that greater loss of adipose tissue correlated with lower survival rates, suggesting that monitoring adipose tissue changes post-surgery could help predict patient outcomes.
Background: Little information is available from prospective clinical trials on the influences of surgical approaches on postoperative quality of life (QOL). We aimed to prospectively compare chronological changes in postoperative body weight and QOL between laparoscopic and open total gastrectomy for stage I gastric cancer (GC).
Methods: We conducted a multi-institutional prospective study (CCOG1504) of patients who undergo laparoscopic or open total gastrectomy.
Background/aim: Post-gastrectomy lean body mass (LBM) decrease has a significant negative impact on postoperative survival in patients with cancer. This study investigated the effect of intake of at least one-third of the daily protein requirement at breakfast on the maintenance of LBM in patients during the first month post-gastrectomy.
Patients And Methods: Among patients with gastric cancer who underwent curative distal gastrectomy between April 2011 and December 2018, without adjuvant chemotherapy, we evaluated 401 patients who had consumed more than the daily protein requirement in the first month postoperatively, using the FFQW82 nutrition intake questionnaire.
Article Synopsis
- Granzyme B (GZMB), produced by NK cells and CD8-positive T cells, plays a role in inducing apoptosis in tumor cells, and its expression was analyzed in gastric cancer (GC) patients post-surgery.
- A study involving 253 patients with pStage II/III GC showed significantly higher GZMB levels in tumor tissues compared to adjacent normal tissues, although it did not correlate with other clinicopathological features.
- The study found that patients with high GZMB expression had a better 5-year overall survival rate (72.0%) compared to those with low expression (55.7%), indicating that GZMB could serve as a valuable prognostic marker in advanced GC.
Article Synopsis
- The study investigates the role of hornerin (HRNR) protein in gastric cancer tissues of patients with advanced stages (II/III) who had surgery.
- HRNR levels were found to be significantly higher in cancerous tissues compared to normal tissues, with sex differences noted.
- Patients with high HRNR expression had a notably lower 5-year overall survival rate, indicating that HRNR could be a valuable prognostic marker for assessing outcomes in these cancer patients.
Background: Approximately 10% of hypertrophic cardiomyopathy (HCM) patients have left ventricular systolic dysfunction (end-stage HCM) leading to severe heart-failure; however, risk stratification to identify patients at risk of progressing to end-stage HCM remains insufficient.
Objectives: In this study, the authors sought to elucidate whether the coexistence of other cardiovascular disease (CVD)-related variants is associated with progression to end-stage HCM in patients with HCM harboring pathogenic or likely pathogenic (P/LP) sarcomeric variants.
Methods: The authors performed genetic analysis of 83 CVD-related genes in HCM patients from a Japanese multicenter cohort.
Article Synopsis
- * Most patients received paclitaxel-based treatments (49%), followed by fluoropyrimidines plus platinum (44%), and irinotecan (7%), with overall response rates of 28.7% and disease control rates of 54.1%.
- * Results indicated a median progression-free survival (PFS) of 5.1 months and overall survival (OS) of 12.9 months, with the combination of paclitaxel and ramucirumab
Article Synopsis
- Clonal hematopoiesis of indeterminate potential (CHIP) is shown to worsen outcomes in patients with nonischemic dilated cardiomyopathy (DCM) despite being well-known for its negative impacts on atherosclerotic disease.
- Researchers analyzed 198 DCM patients using advanced genetic sequencing to find both germline mutations linked to cardiomyopathy and somatic mutations in CHIP driver genes, discovering 25 CHIP mutations in 22 patients.
- The study concluded that CHIP is an independent risk factor for cardiac issues in DCM, contributing to worsened heart function and structural damage, and that genetic mutations can help predict patient prognosis.
Article Synopsis
- The study assessed the Inflammatory Burden Index (IBI) as a potential prognostic marker for gastric cancer (GC) patients undergoing gastrectomy, highlighting its relationship with patient outcomes.
- Researchers analyzed data from 459 patients treated at the Kanagawa Cancer Center, finding that those with a high IBI had lower overall survival and recurrence-free survival rates compared to those with a low IBI.
- The findings suggest that a high preoperative IBI is an independent predictor of poor prognosis, indicating its potential utility in clinical decision-making for GC treatment.
The association of computed tomography (CT)-derived skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) with postoperative prognosis in patients with gastric cancer (GC) remains unknown. Therefore, the present study aimed to assess the association between SMI and SMD with 5-year overall survival (OS) and recurrence-free survival (RFS) in patients with GC. SMI and SMD were measured preoperatively in patients who underwent gastrectomy.
View Article and Find Full Text PDFBackground/aim: The sex-specific effect of the visceral-to-subcutaneous fat ratio (VSR) before gastrectomy on postoperative survival in patients with gastric cancer (GC) remains unclear. This study measured the preoperative VSR in patients with GC and analyzed its relationship with 5-year overall survival (OS) and relapse-free survival (RFS) by sex.
Patients And Methods: This prospective study included 540 patients with GC undergoing gastrectomy.
Background: The heart comprises many types of cells such as cardiomyocytes, endothelial cells (ECs), fibroblasts, smooth muscle cells, pericytes, and blood cells. Every cell type responds to various stressors (eg, hemodynamic overload and ischemia) and changes its properties and interrelationships among cells. To date, heart failure research has focused mainly on cardiomyocytes; however, other types of cells and their cell-to-cell interactions might also be important in the pathogenesis of heart failure.
View Article and Find Full Text PDFNo standard treatment has been established for gastric neuroendocrine carcinoma (G-NEC). We present the case of a patient with recurrent G-NEC who achieved a complete response (CR) with nivolumab. A woman in her 70 s, with no significant medical or family history of illness, underwent an upper gastrointestinal endoscopy, which revealed a Borrmann type 2 tumor in the gastric antrum.
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