Publications by authors named "Takafumi Ueda"
Background: Clear cell sarcoma (CCS) and alveolar soft part sarcoma (ASPS) are rare, and standard systemic therapy is not established except for sunitinib in ASPS. It is known that CCS and ASPS have a common biological feature of melanoma and Xp11.2/TFE3 translocation renal cell carcinoma, and immune-checkpoint inhibitors (ICIs) are effective in these tumors.
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- * The study aimed to analyze the rates of postsurgical complications, local recurrence, and implant failure in a group of 42 patients treated for bone tumors in Japan, looking at various associated factors.
- * Out of the 42 patients, only 69% were able to be monitored for at least two years or reached a study endpoint, highlighting the need for careful candidate selection for TFR due to the serious risks involved.
Purpose: To determine, for patients with advanced or recurrent synovial sarcoma (SS) not suitable for surgical resection and resistant to anthracycline, the safety and efficacy of the infusion of autologous T lymphocytes expressing NY-ESO-1 antigen-specific T-cell receptor (TCR) gene and siRNA to inhibit the expression of endogenous TCR (product code: TBI-1301).
Patients And Methods: Eligible Japanese patients (HLA-A*02:01 or *02:06, NY-ESO-1-positive tumor expression) received cyclophosphamide 750 mg/m2 on days -3 and -2 (induction period) followed by a single dose of 5×109 (±30%) TBI-1301 cells as a divided infusion on days 0 and 1 (treatment period). Primary endpoints were safety-related (phase I) and efficacy-related [objective response rate (ORR) by RECIST v1.
Purpose: Perivascular epithelioid cell tumors (PEComas) of the bone and soft tissues are rare mesenchymal neoplasms, some of which are malignant. However, their clinical and pathological characteristics remain unclear. This study was performed to investigate the clinical and pathological characteristics of PEComas in bone and soft tissues by leveraging information from the Japanese Musculoskeletal Oncology Group.
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- Tumor-devitalized autografts are biological reconstruction methods used after tumor excision in aggressive bone or soft tissue tumors, providing benefits like no disease transmission risk and better fit for the implant site, but they also have limitations including reduced healing potential and biomechanical strength.
- The study aimed to investigate rates of complications (like fracture and infection), 5-year and 10-year graft survival, union rates of the graft-host junction, and overall limb function related to these autografts.
- Conducted as a retrospective study across 26 sarcoma centers in Japan, the research analyzed data from 494 patients over a 25-year period, focusing on the outcomes and factors affecting the effectiveness of these treatments.
This retrospective multicenter study aimed to analyze the clinical features and prognosis of 24 patients diagnosed with LGMS between 2002 and 2019 in the Japanese sarcoma network. Twenty-two cases were surgically treated and two cases were treated with radical radiotherapy (RT). The pathological margin was R0 in 14 cases, R1 in 7 cases, and R2 in 1 case.
View Article and Find Full Text PDFBackground: Dedifferentiated liposarcoma occurs predominantly in the retroperitoneum. Given the paucity of cases, information on the clinical characteristics of this entity in the extremities and trunk wall is quite limited. In particular, the significance of preoperative evaluation and principles of intraoperative management of the different components, i.
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- Aseptic loosening of cemented stems has led to the development of the Kyocera Modular Limb Salvage System (KMLS) cementless stems by the Japanese Musculoskeletal Oncology Group, aiming to improve outcomes for endoprosthetic reconstruction despite challenges like stem breakage and stress shielding.
- A study was conducted on 100 patients with KMLS stems to evaluate prosthesis survival, complications, and functional outcomes, revealing that 88.2% survived at 2 years and 79.6% at 4 years, with younger age linked to poorer survival rates.
- Complications occurred in 31 patients, with 13 requiring revision surgery, and the average functional score at 1 year was
Retroperitoneal sarcomas are rare neoplasms that occur in the retroperitoneum. Complete surgical resection is the only effective treatment option. The prediction of prognosis by histological diagnosis has not yet been established.
View Article and Find Full Text PDFObjective: The mainstay of treatment modality for extra-abdominal desmoid-type fibromatosis (DF) has shifted from surgery, which often impairs ADL/QOL, to conservative treatment including active surveillance. In the present study, we conducted a longitudinal survey on the diagnosis and treatment of DF at facilities belonging to the Japanese Musculoskeletal Oncology Group, which is a research group of facilities specializing in the treatment of bone and soft tissue tumors in Japan to clarify the transition of medical care for extra-abdominal DF.
Methods: The same questionnaire was administered in 2015 and 2018, and responses were obtained from 46 (69%) of 67 facilities and 42 (53%) of 80 facilities in 2015 and 2018, respectively.
A highly permselective nanofiltration membrane was engineered via zwitterionic copolymer assembly regulated interfacial polymerization (IP). The copolymer was molecularly synthesized using single-step free-radical polymerization between 2-methacryloyloxyethyl phosphorylcholine (MPC) and 2-aminoethyl methacrylate hydrochloride (AEMA) (P[MPC--AEMA]). The dynamic network of P[MPC--AEMA] served as a regulator to precisely control the kinetics of the reaction by decelerating the transport of piperazine toward the water/hexane interface, forming a polyamide (PA) membrane with ultralow thickness of 70 nm, compared to that of the pristine PA (230 nm).
View Article and Find Full Text PDFBackground: The role of local surgery in patients with metastatic soft tissue sarcoma (STS) remains unknown. The study aims to assess the clinical outcomes and impact of surgical resection on survival in patients with metastatic STS and elucidate the survival differences between synchronous and metachronous metastatic groups.
Methods: Among the 272 patients with STS treated between 2000 and 2018, 84 with synchronous or metachronous metastasis were included.
Scabies is a highly contagious skin disease caused by the mite Sarcoptes scabiei that affects many mammals. However, the sensitivity of traditional tests for scabies diagnosis in humans is less than 50%. To simplify the diagnosis of scabies, methods that are simple, sensitive, specific, and cost-effective are required.
View Article and Find Full Text PDFBackground: A prospective cohort study was conducted to determine the incidence and risk factors of symptomatic venous thromboembolism (sVTE) during the perioperative period in patients with malignant bone and soft tissue tumors.
Methods: Patients with newly diagnosed primary malignant bone and soft tissue tumors for whom definitive surgery was planned were consecutively registered among 27 tertiary hospitals specializing in musculoskeletal oncology. Clinicopathological information on each patient was collected prospectively, and careful follow-up was conducted for 6 months after surgery.
Background: Although the unpredictable malignant behavior of solitary fibrous tumors (SFTs) has been recognized, the clinical features and prognosis of metastatic SFTs have not been well documented due to the extreme rarity of these cases. The aim of this study is to investigate the clinical features, prognostic factors, and optimal management of patients with metastatic SFTs.
Patients And Methods: Sixty patients with metastatic SFT were retrospectively reviewed.
Article Synopsis
- This study explored the clinical outcomes of 43 patients with bone sarcomas who underwent unplanned surgeries across 23 hospitals in Japan from 2006 to 2017, focusing on patterns and results.
- The majority of patients had osteosarcoma or Ewing sarcoma, with common primary tumor locations being the femur and spine; unplanned procedures included curettage and surgical resections, often accompanied by additional treatments.
- The 5-year disease-specific survival rates varied by tumor type, with a significant decrease in survival for patients who experienced local recurrences compared to those who did not.
Article Synopsis
- The study focused on the effectiveness of pazopanib for treating malignant peripheral nerve sheath tumors (MPNST), which are typically unresponsive to chemotherapy and associated with NF1.
- A phase II clinical trial included 12 patients, with outcomes measured at 12 weeks using clinical benefit rate (CBR), progression-free survival (PFS), and overall survival (OS).
- Findings showed a 50% CBR, median PFS of 5.4 months, and median OS of 10.6 months, indicating that pazopanib could be a safe and more effective treatment option than previous therapies for MPNST.
Alveolar soft part sarcoma (ASPS), epithelioid sarcoma (ES), and clear cell sarcoma (CCS) are known to be chemoresistant tumors. The aim of this study was to investigate the effect of pazopanib on these chemoresistant tumors. This study is designed as a single-arm, multicenter, investigator-initiated phase II trial.
View Article and Find Full Text PDFMethods: We retrospectively reviewed 33 patients who underwent osteoarticular ECIA after bone tumor resection from 1988 to 2014. We investigated complications, radiographic changes by the International Society of Limb Salvage graft evaluation criteria, and functional outcomes according to the Musculoskeletal Tumor Society scoring system.
Results: Fifteen patients were reoperated upon due to infection ( = 9), protruding fixation implant ( = 4), or fracture of the grafted bone ( = 2).
A long-term follow-up study of extracorporeal irradiated autografts in limb salvage surgery for malignant bone and soft tissue tumors: A minimum follow-up of 10 years after surgery.
J Surg Oncol
June 2020
Background And Objectives: The aim of this study is to assess the survival, function, radiographic appearance, and modes of failure of extracorporeal irradiated (ECI) autografts in a long-term setting.
Methods: We retrospectively reviewed 87 patients who were treated for bone and soft tissue tumors using ECI autografts between 1988 and 2009.
Results: The 56 patients had a minimum follow-up of 10 years, and the median follow-up period was 16.
The time course of the response to each drug is important to avoid inappropriate termination of treatment by misjudging tumor progression; however, little is known about soft tissue sarcoma (STS) regarding this matter. This study aimed to perform a time-lapse analysis of tumor response in patients with STS treated with trabectedin from 2 phase II clinical trials. We examined 66 patients with translocation-related sarcoma registered in 2 Japanese phase II clinical trials.
View Article and Find Full Text PDFBackground: Chondroblastoma (CB) is a rare locally aggressive bone tumor that commonly occurs in the epiphysis or apophysis of long bones. Although surgical treatment of CB carries potential risk for physeal or articular cartilage damage, risk factors for joint degeneration have not been well described. In addition, we have mainly used synthetic bone substitute (SBS) to fill the bone defect after intralesional curettage as treatment for CB.
View Article and Find Full Text PDFAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
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