Publications by authors named "Koki Shimizu"
Background: A wide inequality exists between high- and low-income countries in the outcome of paediatric acute lymphoblastic leukaemia (ALL). At a tertiary-level hospital in Tanzania, multidimensional approaches have been taken to improve cancer care for children. This study aimed to update the outcomes of paediatric ALL at Muhimbili National Hospital (MNH), Tanzania from 2016 to 2020.
View Article and Find Full Text PDFCancer inequalities are wide and enduring, within countries between socio-demographic groups and between countries. These are generated and sustained throughout the key phases of the cancer pathway, from investigation, clinical assessment, decision and access to treatment, and follow-up care. We aimed to describe the characteristics of implemented interventions, evaluated in published controlled experiments in the medical literature, specifically designed to target reductions in inequalities along the cancer pathway.
View Article and Find Full Text PDFAnticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The purpose of this study was to identify an effective drug with fewer side effects against DF by drug repositioning, and evaluate its efficacy. FDA-approved drugs that inhibit the proliferation of DF cells harboring S45F mutations of CTNNB1 were screened.
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- * The study included 62 patients with DDCS and 19 with G3CS, revealing that R0 resection was achieved in the majority of cases and highlighting that the 5-year disease-specific survival (DSS) was 18.5% for DDCS and 41.7% for G3CS.
- * Key factors influencing prognosis included stage and treatment type, with poor overall survival indicating a need for more effective chemotherapy options
Article Synopsis
- Nursing facilities in Nagasaki were at high risk for COVID-19 due to factors like close quarters, elderly residents, and underlying health issues; the local health system's response to this outbreak was unclear.
- Data was collected on COVID-19 cases from April 2020 to June 2021, which included universal screening of healthcare workers and nursing facility users following the first case in a facility.
- Out of the analyzed population, nursing facility users had a higher death rate from COVID-19, underlining the need for effective prevention strategies to manage outbreaks and protect vulnerable residents.
Article Synopsis
- The study investigates how diffusion-weighted imaging (DWI) can help differentiate between benign plexiform neurofibromas (pNF) and malignant peripheral nerve sheath tumors (MPNST) in patients with neurofibromatosis type 1 (NF1).
- Researchers analyzed 29 NF1 cases, comparing diagnostic features and apparent diffusion coefficient (ADC) values using magnetic resonance imaging (MRI).
- Results showed significant differences in tumor characteristics between pNF and MPNST, with DWI providing a valuable tool for differentiation, increasing diagnostic accuracy when used alongside standard MRI evaluations.
Objective: The mainstay of treatment modality for extra-abdominal desmoid-type fibromatosis (DF) has shifted from surgery, which often impairs ADL/QOL, to conservative treatment including active surveillance. In the present study, we conducted a longitudinal survey on the diagnosis and treatment of DF at facilities belonging to the Japanese Musculoskeletal Oncology Group, which is a research group of facilities specializing in the treatment of bone and soft tissue tumors in Japan to clarify the transition of medical care for extra-abdominal DF.
Methods: The same questionnaire was administered in 2015 and 2018, and responses were obtained from 46 (69%) of 67 facilities and 42 (53%) of 80 facilities in 2015 and 2018, respectively.
Background: Campylobacter fetus is an uncommon Campylobacter species, and its infections mainly cause infective endocarditis, aortic aneurysm, and meningitis rather than enteritis. It is more likely to be detected in blood than Campylobacter jejuni or Campylobacter coli, specifically reported in 53% of patients. In our case, C.
View Article and Find Full Text PDFObjective: The treatment modality for desmoid-type fibromatosis has shifted from surgery to conservative treatment. The guideline committee for clinical care of extra-abdominal desmoid-type fibromatosis in Japan conducted a systematic review of treatment with doxorubicin-based chemotherapy for desmoid-type fibromatosis.
Methods: We searched the pertinent literature.
Article Synopsis
- * Of 196 cases analyzed, the 5-year local recurrence-free survival rate was 52.9%, with significant adverse factors identified as extremity location and larger tumor size.
- * The findings emphasized that extremity location was the key factor influencing recurrence and highlighted the need for better methods to identify CTNNB1 mutations for future research.
Background: The mainstay of the treatment for desmoid-type fibromatoses has been shifting from surgery to drug treatment, making accurate prediction of the efficacy of drug treatment of extreme importance. On the other hand, desmoid-type fibromatoses arise everywhere in the body. The purpose of this systematic review was to address the clinical question of whether tumour location has an impact on the efficacy of drug treatment.
View Article and Find Full Text PDFIs mutation analysis of β-catenin useful for the diagnosis of desmoid-type fibromatosis? A systematic review.
Jpn J Clin Oncol
September 2020
Background: An accurate diagnosis is crucial to determine the treatment modality for desmoid-type fibromatosis, although the histopathological diagnosis is occasionally difficult to make. Many desmoid-type fibromatosis have been reported to have hotspot mutation of β-catenin gene (CTNNB1). In the present study, we performed a systematic review to verify the usefulness of CTNNB1 mutation analysis in the diagnosis of desmoid-type fibromatosis.
View Article and Find Full Text PDFObjective: The treatment modality for desmoid-type fibromatosis has shifted from surgery to conservative treatment. This systematic review aims to evaluate the efficacy of low-dose chemotherapy with methotrexate and vinblastine for patients with extra-abdominal desmoid-type fibromatosis.
Methods: We searched the pertinent literature from January 1990 to August 2017.
MRI characteristics predict the efficacy of meloxicam treatment in patients with desmoid-type fibromatosis.
J Med Imaging Radiat Oncol
December 2019
Introduction: This study aimed to determine the clinical significance of MRI characteristics as a possible predictor of responsiveness to meloxicam treatment in patients with desmoid-type fibromatosis (DF). Additionally, it analysed the correlation between CTNNB1 mutation status and signal intensity of MRI.
Methods: Forty-six patients consecutively treated with meloxicam composed this study.
Immunohistochemical staining with anti-β-catenin antibody has been applied as a diagnostic tool for desmoid-type fibromatoses (DFs). In recent years, specific gene mutation (CTNNB1) analysis has also been reported to be useful for diagnosis of DF; however, the association between CTNNB1 mutation status and immunohistochemical staining pattern of β-catenin is rarely reported. The purposes of this study are to clarify the relationship of the staining pattern of β-catenin with the CTNNB1 mutation status and various clinical variables, and to investigate the significance of immunohistochemical staining of β-catenin in cases diagnosed as DF.
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