Efficiency of Endoluminal Vacuum-Assisted Closure Therapy for Pharyngocutaneous Fistula.

The aim of this study was to evaluate the efficacy of endoluminal vacuum-assisted closure (EndoVAC) therapy for patients with pharyngocutaneous fistula by placing a sponge in the intraluminal pharyngeal space using a transoral approach. The authors retrospectively enrolled 12 patients with pharyngocutaneous fistula, who were treated with EndoVAC therapy from 2023 to 2024. Of the 12 patients, 10 patients had pharyngocutaneous fistula after surgery for head and neck malignancy, 1 patient had a leak in the pharyngoesophageal junction caused by bougienage, and 1 patient had a pharyngocutaneous fistula associated with antiphospholipid syndrome.

Analysis of Helicobacter pylori Infection Status and Clarithromycin-resistant Strains in Patients With Gastric Mucosa-associated Lymphoid Tissue Lymphoma Using Real-time Polymerase Chain Reaction: A Single-center Korean Study.

Background: Helicobacter pylori (HP) is a well-known risk factor for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the prevalence of clarithromycin-resistant (CLR) HP strains in patients with gastric MALT lymphoma compared with the general population is largely unknown.

Materials And Methods: HP test was performed on samples from 4686 patients who underwent gastric biopsy, including 89 patients who were diagnosed with gastric MALT lymphoma.

Clinical features and outcomes of thyroid hyalinizing trabecular tumors: An 11-year experience at a tertiary referral hospital.

Hyalinizing trabecular tumors (HTTs) of the thyroid are rare neoplasms that generally exhibit benign behavior, lacking capsular or vascular invasion. Despite this, HTTs often present histopathological features that closely resemble those of papillary thyroid carcinoma (PTC), posing an important diagnostic challenge and leading to the frequent misinterpretation of fine needle aspiration biopsy (FNAB) results as PTC. The present study aimed to investigate the clinical characteristics and outcomes of HTTs observed over 11 years at a tertiary referral hospital [Chonnam National University Hwasun Hospital (Hwasun, South Korea)].

Claudin 18.2 expression profile in primary tumors and their ovarian metastases: implications for targeted therapy.

Background: Claudin 18.2 (CLDN18.2), a tight junction protein predominantly expressed in the normal gastric epithelium, has recently emerged as a potential therapeutic target in various solid tumors.

Role of Keratin-10 in Tumor Progression and Radioresistance of Laryngeal Cancer Cells.

Background/aim: Advanced laryngeal cancer is challenging to treat, and overall survival rates are low. The high rate of disease recurrence contributes significantly to poor outcomes. This study investigated the role of keratin-10 (KRT10), identified through RNA sequencing as a potential target molecule in laryngeal cancer, in the tumor progression and radioresistance of laryngeal cancer cells.

MicroRNA-129-3p Suppresses Tumor Progression and Chemoradioresistance in Head and Neck Squamous Cell Carcinoma.

(1) Background: MicroRNA-129 (miR-129) participates in tumor progression and chemoresistance in various cancer types. In this study, the role of miR-129-3p, the main mature form of miR-129, in tumor progression and chemoradiotherapy resistance in head and neck cancer was evaluated. (2) Methods: RT-PCR, western blotting, cell proliferation assays, cell apoptosis assays, and cell invasion and migration assays were used.

Alleviation of Menopausal Symptoms by Yam (Dioscorea japonica Thunb.) and Gromwell (Lithospermum erythrorhizon Sieb. Et Zucc.) Extracts in Ovariectomized Mice.

Scope: The decline in estrogen during menopause contributes to a variety of menopausal symptoms, for which hormone replacement therapy (HRT) has been extensively applied. Regarding side effects and limited effectiveness of HRT for specific individuals, there is a growing interest in safe alternatives such as phytoestrogens which are structurally analogous to estrogens. This study aims to investigate the efficacy of yam and gromwell extracts, rich in bioactive compounds, and the synergistic effect of extracts on symptoms induced by estrogen deficiency in ovariectomized (OVX) mice.

Efficacy of natural killer cell therapy combined with chemoradiotherapy in murine models of head and neck squamous cell carcinoma.

Background Aims: Natural killer (NK) cell-based cancer immunotherapy is effective when combined with other treatment modalities such as irradiation and chemotherapy. NK cell's antitumor function to treat solid tumor, including head and neck squamous cell carcinoma (HNSCC), has been targeted recently. This study assessed NK cell recruitment in response to chemoradiation therapy (CRT) in HNSCC.

Synergistic Antibacterial Activity of an Active Compound Derived from against Methicillin-Resistant and Its Clinical Isolates.

There are a growing number of reports of hospital-acquired infections caused by pathogenic bacteria, especially methicillin-resistant (MRSA). Many plant products are now being used as a natural means of exploring antimicrobial agents against different types of human pathogenic bacteria. In this research, we sought to isolate and identify an active molecule from that has possible antibacterial activity against various clinical isolates of MRSA.

Inhibitor of apoptosis protein Livin promotes tumor progression and chemoradioresistance in human anaplastic thyroid cancer.

Anaplastic thyroid cancer (ATC) is characterized by a rapid and aggressive course of progression. Despite significant advances in surgery, radiotherapy and chemotherapy, the disease‑specific mortality due to ATC is approximately 100%. New strategies, such as molecular targeted therapies, are imperative for improving survival.

Comparison of long-term treatment outcomes of T2N0M0 laryngeal squamous cell carcinoma using different treatment methods.

Early [stage I and II (T2N0M0)] laryngeal cancer types are currently recommended to be treated with a single modality, consisting of definitive radiation therapy or larynx-preserving surgery. Although the treatment outcomes of stage I are good, the frequency of successful outcomes decreases with T2N0M0. Therefore, the present study investigated the treatment outcomes of different treatment methods in T2N0M0 laryngeal cancer.

Gelatin Sponge Induced Maxillary Sinusitis After Transsphenoidal Pituitary Surgery.

Transsphenoidal pituitary surgery is a safe, well-established treatment method, but it is associated with several postoperative nasal complications. However, gelatin sponge induced maxillary sinusitis after transsphenoidal pituitary surgery has not been reported. In this study, we present an unusual case of gelatin sponge induced maxillary sinusitis after transsphenoidal pituitary surgery.

Metastatic small cell neuroendocrine carcinoma of the submandibular gland from the lung: A case report.

Rationale: Small cell neuroendocrine carcinoma of the salivary gland is an extremely rare condition. To the best of our knowledge, metastasis of small cell neuroendocrine lung cancer to the submandibular gland has not been reported in the literature.

Patient Concern: An 87-year-old female complained of a left neck mass that enlarged from one month ago.

Intensity-modulated radiotherapy for stage I glottic cancer: a short-term outcomes compared with three-dimensional conformal radiotherapy.

Purpose: To investigate the differences in treatment outcomes between two radiation techniques, intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT).

Materials And Methods: We retrospectively analyzed 160 (IMRT = 23, 3DCRT = 137) patients with stage I glottic cancer treated from January 2005 through December 2016. The IMRT was performed with TomoTherapy (16 patients), volumetric-modulated arc therapy (6 patients), and step-and-shoot technique (1 patient), respectively.

Clinical difference between benign and malignant tumors of the hard palate.

Objective: To determine the clinical characteristics and treatment results of benign and malignant tumors of the hard palate in our hospital.

Patients And Methods: A total of 25 patients who underwent surgical treatment for hard palate tumors between 2008 and 2018 were included in this study. Their demographic characteristics, smoking status, alcohol consumption, symptoms, duration of symptoms, size and localization of hard palate tumor, status of mucosal surface, radiologic examinations, surgery, reconstruction method, histopathologic results, treatment outcomes, oral intake start time, adjuvant treatment, postoperative complications, and recurrence were reviewed.

Nasal Septum Actinomycosis Mimicking Mucocele.

Actinomycosis commonly occurs in the cervicofacial region, but rarely in the paranasal sinus. The authors report an unusual case of nasal septum actinomycosis that was mistaken for a mucocele. The patient was treated accordingly using antibiotic therapy after endoscopic sinus surgery was performed.

Cavernous Lymphangioma in the Maxillary Sinus.

Lymphangioma in the maxillary sinus is rare. Herein, the authors report an unusual case of cavernous lymphangioma, in the maxillary sinus, with imaging examinations. Clinicians should be aware of the possibility of lymphangioma in the maxillary sinus, and be capable of distinguishing it, from other benign cystic lesions.

Evaluation of Prognostic Factors for the Parotid Cancer Treated With Surgery and Postoperative Radiotherapy.

Objectives: To investigate the prognostic factors and treatment outcomes of primary parotid carcinoma treated with surgery and postoperative radiotherapy (PORT).

Methods: We reviewed retrospectively 57 patients with primary parotid carcinoma who were treated with surgery and PORT between 2005 and 2014. Superficial parotidectomy was performed in 19 patients, total parotidectomy in 10 patients, and total parotidectomy with lymph node dissection in 28 patients PORT on the tumor bed was performed in 41 patients, while PORT on tumor bed and ipsilateral cervical lymph nodes was performed in 16 patients.

Computed tomography-based differential diagnosis of fungus balls in the maxillary sinus.

Objective: We investigated the computed tomography (CT) features of the maxillary sinus fungus ball and compared them with those of other maxillary sinus diseases.

Study Design: The CT findings of 98 fungus ball lesions in 96 patients, with 35 cases of sinusitis confined to the maxillary sinus and 35 other sinus lesions confined to the maxillary sinus, were analyzed.

Results: The most common CT feature of maxillary sinus fungus balls was calcification within the maxillary sinus (n = 77 [78.

Receptor tyrosine kinase, RON, promotes tumor progression by regulating EMT and the MAPK signaling pathway in human oral squamous cell carcinoma.

The receptor tyrosine kinase, recepteur d'origine nantais (RON), is known to be associated with the progression, metastasis, and prognosis of various types of cancers. Nevertheless, the role of RON in human oral squamous cell carcinoma (OSCC) is unclear. This study evaluated whether RON affects oncogenic behavior, oncogenic signaling pathways, and clinical outcomes, including survival, in human OSCC.

Coexistence of Antrochoanal Polyp and Fibrous Dysplasia in the Maxilla.

The authors report an unusual case of coexistence of antrochoanal polyp (ACP) and fibrous dysplasia (FD) in the maxilla. To the best of our knowledge, this condition has never been reported in the literature. The complete removal of the ACP through endoscopic sinus surgery was attained and FD was ultimately diagnosed by histopathological examination.

Anthracofibrotic Lymph Node of Neck Mimicking Metastatic Malignant Melanoma in a Patient With Gastric Cancer.

Extrathoracic anthracofibrosis in head and neck region is of extremely rare occurrence and can be confused with malignancy. In this article, we report an unusual case of an anthracofibrotic lymph node of neck that was mistaken for metastatic malignant melanoma in a gastric cancer patient. Because the incidence of an anthracofibrotic lymph node of the neck is very low, it is important to distinguish it from other diseases, including malignancy or metastasis, especially in patients with a cancer history.

External Jugular Vein Aneurysm in a Child With Hemophilia A.

An external jugular vein (EJV) aneurysm is an extremely rare disease. Ultrasonography with color doppler methods is considered the criterion standard for diagnosis of a venous aneurysm. The treatment of choice for an EJV aneurysm is surgical excision.

Guidelines for the Surgical Management of Oral Cancer: Korean Society of Thyroid-Head and Neck Surgery.

Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to provide guidance on the implementation of a surgical treatment of oral cancer. MEDLINE databases were searched for articles on subjects related to "surgical management of oral cancer" published in English. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies.