NOD2 Promotes Glioblastoma Progression Through Effects on Epithelial-Mesenchymal Transition and Cancer Stemness.

: Glioblastoma multiforme (GBM) represents one of the most aggressive and lethal primary brain malignancies, characterized by rapid proliferation, extensive invasiveness, and a dismal prognosis. Emerging evidence implicates nucleotide-binding oligomerization domain-containing protein 2 (), an intracellular pattern recognition receptor, as a potential driver of GBM progression. This study investigates NOD2's role in promoting glioblastoma through its effects on the epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) markers.

An insight into pyocyanin: production, characterization, and evaluation of its in vitro antibacterial, antifungal, antibiofilm and in vivo anti-schistosomal potency.

Background: Tackling the high demand for alternative therapeutic options, especially for multi-drug-resistant organisms, has awakened interest in naturally originated biomolecules such as pyocyanin (PYO). Herein, PYO-producing bacterium was isolated and PYO was extracted, characterized, and its antagonistic potency was scrutinized against a vast array of prokaryotic and eukaryotic water pathogens, either in free-living or biofilm lifestyles, both in vitro and in vivo.

Results: Initially, sp.

Environmental distribution of biofilm-forming antibiotic-resistant Escherichia coli associated with plastic surface materials.

Plastic pollution is now an emerging issue worldwide, and the amount of plastic debris is rapidly increasing day by day in this decade. The surface of plastic contains a wide variety of biofilm-forming microorganisms that can pose a risk to human health. Studies showed that Escherichia coli is resistant to numerous classes of antibiotics; however, the prevalence of the bacterium on the environmental plastic surface is still unknown.

Clinico-pathological analysis of oral red and white mucosal lesions in iron-deficiency anemia among non-tobacco-users.

The relation between hematological parameters and the presence of oral red and white mucosal lesions among non-tobacco-using adults diagnosed with iron-deficiency anemia is of interest. Hematological parameters, including hemoglobin, serum ferritin, MCV, MCH and RDW, were recorded. Clinical oral examinations identified red (erythroplakia, atrophic glossitis) and white lesions (oral candidiasis, leukoplakia-like patches and angularcheilitis).

Therapeutic potential of greenly synthesized selenium nanoparticles against experimental cyclosporiasis.

Cyclospora cayetanensis (C. cayetanensis), an opportunistic intracellular coccidian, is responsible for chronic debilitating diarrheal outbreaks possessing life-threatening penalties, especially in immunocompromised patients. The solemn therapeutic agents against cyclosporiasis are limited by their grave effects and high recurrence rate.