The genomic SELEX-based method identifies 350 SigA-specific promoters in Mycobacterium tuberculosis.

The gene regulation in Mycobacterium tuberculosis by different sigma factors, including the principal sigma factor, sigmaA (SigA), is poorly understood. Here, we have developed a modified genomic systematic evolution of ligands by exponential enrichment (SELEX)-Seq approach that identifies 350 new SigA-binding sites in M. tuberculosis.

Emerging Role of 2D Materials in Photovoltaics: Efficiency Enhancement and Future Perspectives.

The growing global energy demand and worsening climate change highlight the urgent need for clean, efficient and sustainable energy solutions. Among emerging technologies, atomically thin two-dimensional (2D) materials offer unique advantages in photovoltaics due to their tunable optoelectronic properties, high surface area and efficient charge transport capabilities. This review explores recent progress in photovoltaics incorporating 2D materials, focusing on their application as hole and electron transport layers to optimize bandgap alignment, enhance carrier mobility and improve chemical stability.

Genomic similarity of carbapenem-resistant Enterobacterales collected from mothers and their neonates.

Objective: New Delhi metallo-β-lactamase is endemic in India and the gut may act as a reservoir of carbapenemase-producing Enterobacterales (CPE). Maternal gut colonisation with bla-harbouring CPE increases the risk of neonatal gut colonisation. This study aimed to assess the vertical transmission of CPE from pregnant mothers (rectal) to neonates (rectal and blood).

State-of-the-Art, Insights, and Perspectives for MOFs-Nanocomposites and MOF-Derived (Nano)Materials.

Composite structures created from metal‒organic framework (MOF) matrices are reviewed in this work. Depending on the nature of the second component apart from the MOF platform, several synergistic properties may arise; at the same time, the initial features of the single constituent materials are usually maintained, and individual shortcomings are mitigated. Currently, timely energy and environmental challenges necessitate the quest for more advanced materials and technologies.

Zirconium hafnium: a comparative study of mesoporous MOF stability.

A wide range of mesoporous Zr and Hf metal-organic frameworks (MOFs), namely MIP-206, MOF-808, and NU-1000, as well as the microporous UiO-66, were systematically investigated and compared in terms of thermal and chemical stability. The holistic effects of metal type (Zr Hf), linker type (small and rigid large and flexible), and framework topology (2D 3D) on the overall framework stability were investigated.

Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment.

Telomeres are crucial for cancer progression. Immune signalling in the tumour microenvironment has been shown to be very important in cancer prognosis. However, the mechanisms by which telomeres might affect tumour immune response remain poorly understood.

pH-Independent Selective Formation of VO Motif Incorporating a Family of Hydrazone Ligands: Synthesis, Structure, and Luminescence-Based Sensing Studies toward Selective Metal Ions.

Two new dioxidovanadium(V) compounds with the general formula [VO(L)] (L = hydrazone ligand) were synthesized using three different methods (acidic, neutral, and basic media) with either VOSO. 5HO, [VO(acac)], or NHVO as the starting material and hydrazone ligands. In both cases, five coordinated V ions adopted distorted square pyramidal geometry through the coordination of two oxido ligands and one hydrazone ligand.

Aquificae overcomes competition by archaeal thermophiles, and crowding by bacterial mesophiles, to dominate the boiling vent-water of a Trans-Himalayan sulfur-borax spring.

Trans-Himalayan hot spring waters rich in boron, chlorine, sodium and sulfur (but poor in calcium and silicon) are known based on PCR-amplified 16S rRNA gene sequence data to harbor high diversities of infiltrating bacterial mesophiles. Yet, little is known about the community structure and functions, primary productivity, mutual interactions, and thermal adaptations of the microorganisms present in the steaming waters discharged by these geochemically peculiar spring systems. We revealed these aspects of a bacteria-dominated microbiome (microbial cell density ~8.

Heavy Metal-Based Toxic Oxo-Pollutants Sequestration by Advanced Functional Porous Materials for Safe Drinking Water.

ConspectusWater scarcity as a consequence of either environmental or economic actions is the most compelling global concern of the 21st century, as ∼2 billion people (26% of the total population) struggle to access safe drinking water and ∼3.6 billion (46% of the total population) lack access to clean water sanitation. In this context, groundwater pollution by toxic heavy metals and/or their oxo-pollutants, such as CrO, CrO, AsO, SeO, SeO, TcO, UO, etc.

Metal-Organic Frameworks for Dual Photo-Oxidation and Capture of Arsenic from Water.

Despite rapid technological progress, heavy metal water pollution, and particularly arsenic contamination, remains a significant global challenge. In addition, the stabilization of trivalent arsenic as neutral arsenite (As) species hinders its removal by conventional sorbents. While adsorption of anionic arsenate (As) species is in principle more feasible, there are only few adsorbents capable of adsorbing both forms of arsenic.

AMPK activation reduces cancer cell aggressiveness via inhibition of monoamine oxidase A (MAO-A) expression/activity.

Aim: AMPK can be considered as an important target molecule for cancer for its unique ability to directly recognize cellular energy status. The main aim of this study is to explore the role of different AMPK activators in managing cancer cell aggressiveness and to understand the mechanistic details behind the process.

Main Methods: First, we explored the AMPK expression pattern and its significance in different subtypes of lung cancer by accessing the TCGA data sets for LUNG, LUAD and LUSC patients and then established the correlation between AMPK expression pattern and overall survival of lung cancer patients using Kaplan-Meire plot.

Hemilabile Binding of Acetylene in an Amide-Rich Ultramicroporous MOF Enables Strong Acetylene Selectivity.

Thanks to a hemilabile amide-based binding site, a previously unreported amide-functionalized metal-organic framework (MOF) exhibits high acetylene affinity over ethylene, methane, and carbon dioxide, three-in-one.

Nanoscience and nanotechnology for water remediation: an earnest hope toward sustainability.

Water pollution and the global freshwater crisis are the most alarming concerns of the 21st century, as they threaten the sustainability and ecological balance of the environment. The growth of global population, climate change, and expansion of industrial processes are the main causes of these issues. Therefore, effective remediation of polluted water by means of detoxification and purification is of paramount importance.

Extremely oligotrophic and complex-carbon-degrading microaerobic bacteria from Arabian Sea oxygen minimum zone sediments.

Sediments underlying marine hypoxic zones are huge sinks of unreacted complex organic matter, where despite acute O limitation, obligately aerobic bacteria thrive, and steady depletion of organic carbon takes place within a few meters below the seafloor. However, little knowledge exists about the sustenance and complex carbon degradation potentials of aerobic chemoorganotrophs in these sulfidic ecosystems. We isolated and characterized a number of aerobic bacterial chemoorganoheterotrophs from across a ~ 3 m sediment horizon underlying the perennial hypoxic zone of the eastern Arabian Sea.

Surfactant-Mediated Highly Conductive Cellulosic Inks for High-Resolution 3D Printing of Robust and Structured Electromagnetic Interference Shielding Aerogels.

Technological fusion of emerging three-dimensional (3D) printing of aerogels with gel processing enables the fabrication of lightweight and functional materials for diverse applications. However, 3D-printed constructs via direct ink writing for fabricating electrically conductive structured biobased aerogels suffer several limitations, including poor electrical conductivity, inferior mechanical strength, and low printing resolution. This work addresses these limitations via molecular engineering of conductive hydrogels.

Nanotrap Grafted Anionic MOF for Superior Uranium Extraction from Seawater.

On-demand uranium extraction from seawater (UES) can mitigate growing sustainable energy needs, while high salinity and low concentration hinder its recovery. A novel anionic metal-organic framework (iMOF-1A) is demonstrated adorned with rare Lewis basic pyrazinic sites as uranyl-specific nanotrap serving as robust ion exchange material for selective uranium extraction, rendering its intrinsic ionic characteristics to minimize leaching. Ionic adsorbents sequestrate 99.

Porous organic polymers (POPs) for environmental remediation.

Modern global industrialization along with the ever-increasing growth of the population has resulted in continuous enhancement in the discharge and accumulation of various toxic and hazardous chemicals in the environment. These harmful pollutants, including toxic gases, inorganic heavy metal ions, anthropogenic waste, persistent organic pollutants, toxic dyes, pharmaceuticals, volatile organic compounds, , are destroying the ecological balance of the environment. Therefore, systematic monitoring and effective remediation of these toxic pollutants either by adsorptive removal or by catalytic degradation are of great significance.

Palladium-Anchored N-Heterocyclic Carbenes in a Porous Organic Polymer: A Heterogeneous Composite Catalyst for Eco-Friendly C-C Coupling.

Aggregation-induced catalyst deactivation during the reaction in supported metal catalysts prevails as one of the pitfalls toward their practical implementation. Herein, a homogeneously dispersed palladium-coordinated N-heterocyclic carbene (NHC) was strategically integrated inside a microporous hyper-cross-linked polymer via post-synthesis structural modulation. Successful immobilization of spatially isolated Pd (II) units onto the polymer scaffold yielded highly robust heterogeneous catalysts 120-MI@Pd NHC and 120-EI@Pd NHC, respectively.

Ionic metal-organic frameworks (iMOFs): progress and prospects as ionic functional materials.

Metal-organic frameworks (MOFs) have been a research hotspot for the last two decades, witnessing an extraordinary upsurge across various domains in materials chemistry. Ionic MOFs (both anionic and cationic MOFs) have emerged as next-generation ionic functional materials and are an important subclass of MOFs owing to their ability to generate strong electrostatic interactions between their charged framework and guest molecules. Furthermore, the presence of extra-framework counter-ions in their confined nanospaces can serve as additional functionality in these materials, which endows them a significant advantage in specific host-guest interactions and ion-exchange-based applications.

Thermal Endurance by a Hot-Spring-Dwelling Phylogenetic Relative of the Mesophilic .

High temperature growth/survival was revealed in a phylogenetic relative (SMMA_5) of the mesophilic isolated from the 78 to 85°C water of a Trans-Himalayan sulfur-borax spring. After 12 h at 50°C, or 45 min at 70°C, in mineral salts thiosulfate (MST) medium, SMMA_5 retained ~2% colony forming units (CFUs), whereas comparator had 1.5% and 0% CFU left at 50°C and 70°C, respectively.

Hydroxy-Functionalized Hypercrosslinked Polymers (HCPs) as Dual Phase Radioactive Iodine Scavengers: Synergy of Porosity and Functionality.

Large-scale nuclear power plant production of iodine radionuclides ( I, I) pose huge threat in the events of nuclear disaster. Effective removal of radioiodine from nuclear waste is one of the most critical challenge because of the drawbacks of state-of-the-art adsorbents such as high cost, low uptake capacity and non-recyclability. Herein, two hydroxy-functionalized (-OH) hypercrosslinked polymers (HCPs), namely HCP-91 and HCP-92, have been synthesized and employed towards capture of iodine.