Rampant Cystic Metastases From Oral Squamous Cell Carcinoma on 18F-FDG PET/CT: A Rare Clinical Presentation Showing Interplay of Inflammation and Malignancy.

Patients with advanced-stage squamous cell carcinoma (SCC) of tongue often have a poor long-term prognosis, despite advances in diagnosis and management. Imaging is pivotal for staging, restaging and assessing treatment response in these malignancies. To improve patient outcomes, in addition to the commonly used TNM staging, it is crucial to investigate new indicators for prognosis prediction and to inform treatment therapy, which usually occurs before or in synchrony with structural changes.

Intracranial and Extracranial Vascular Involvement in Takayasu Arteritis Unresponsive to Multiple Lines of Immunomodulation on 68Ga-FAPI PET/CT: A Game Changer.

Takayasu arteritis (TAK) is a large-vessel vasculitis characterized by granulomatous inflammation of the aorta and its primary branches. The clinical presentation of TAK is heterogeneous. Intracranial vascular involvement in TAK is uncommon and is understudied.

Lu-177 DOTATATE Therapy in a Treatment Naive Metastatic NET Pineal Gland With Drop Metastasis to Spinal Cord: A Great Leap Forward in Oncology.

Neuroendocrine tumors (NETs) are a heterogeneous group of tumors, which are usually indolent with metastatic disease at the initial presentation in most clinical situations. Intramedullary spinal cord metastasis (ICSM) is usually rare in the case of neuroendocrine tumors. Peptide receptor radionuclide therapy (PRRT) with Lu-177 DOTATATE has been in use for treatment of metastatic NETs for a long time.

Circlet Sign: Urinary Contamination on 177Lu-DOTATATE Posttherapy Imaging.

Peptide receptor radionuclide therapy has revolutionized the management of somatostatin receptor-positive metastatic neuroendocrine tumours. Treating nuclear medicine physicians must be aware of the radiation hazards posed by radioactive contamination and the imaging fallacies attributable to radioactive contamination on posttherapy planar imaging. The image fallacies, if not properly looked upon, upstage the disease.

Ga FAPI PET in a Renal Transplant Patient with Disseminated Nocardiosis-A Worthwhile Imaging Modality for Infection Imaging.

Nocardiosis, an opportunistic infection occurs in immunodeficient population commonly in organ transplant recipients. Patients with risk factors likely chronic corticosteroids and immunosuppressants consumption usually have a higher tendency for disseminated infections with formation of deep abscesses at various sites in the body. Functional imaging with PET, being a whole body imaging offers information about the various sites of disease, thereby assisting the treatment planning, treatment response and also to identify the sites of biopsy.

"Snake in the Scrotum Sign": Reappraising the Potential of 18 F-FDG PET/CT in Post-Renal Transplant Patient with Pyrexia of Unknown Origin.

18 F-FDG PET/CT, the workhorse of oncological imaging has changed the diagnostic and management paradigm in cases of fever and inflammation of unknown origin, with diagnostic superiority over the conventional imaging modalities. Various complications like acute and chronic graft pyelonephritis, acute rejection, infections, and surgery-related complications can occur post-renal transplantation. The authors in the present study demonstrate coexisting graft pyelonephritis, prostatitis, epididymo-orchitis, and funiculitis on 18 F-FDG PET/CT in a patient, post renal transplant with clinical presentation as pyrexia of unknown origin.

18 F-FDG PET/CT in Seronegative Paraneoplastic Limbic Encephalitis Related to Gastrointestinal Stromal Tumor With Coexisting Sepsis.

Paraneoplastic limbic encephalitis (PLE) is proposed to be triggered by oncoantibodies in response to the malignancies, which cross-react with the self-antigens in the neurons. Patients usually manifest a wide range of clinical presentations and neuropsychiatric symptoms like memory loss, mood changes, behavioral disorders, altered state of consciousness, and seizures. Lung carcinoma is the most common malignancy associated with PLE.

Exploring the Role of [Ga]Ga-DOTAGA-IAC and Comparison of Its Diagnostic Performance with [F]F-FDG PET/CT in Radioiodine Refractory Differentiated Thyroid Carcinoma.

Integrin antagonist complex (IAC), a novel αβ integrin antagonist peptidomimetic, has emerged as a promising agent for molecular imaging of tumor angiogenesis. This study evaluates the biodistribution and clinical efficacy of [Ga]Ga-DOTAGA-IAC PET/CT in detecting radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC), comparing its diagnostic performance with [F]F-FDG PET/CT. In this prospective pilot study, RAIR-DTC patients underwent whole-body imaging with [F] F-FDG PET/CT, followed by [Ga]Ga-DOTAGA-IAC PET/CT.

"Bilateral Hot Forearm Sign": Ingeminating the Pattern of Physiological Uptake of F-Fludeoxyglucose.

Exertion and exercise increase glucose metabolism within the skeletal muscles causing increased fludeoxyglucose (FDG) uptake on F-FDG positron emission tomography/computed tomography (PET/CT). Here, we present findings of F-FDG PET/CT in a patient with acute viral hepatitis A-induced liver failure with multiple foci of pyoderma and incessant itching resulting in increased FDG uptake in the muscles of the bilateral forearm, producing the "bilateral hot forearm sign."

Annotating the Role of F-FDG PET/CT in Fibromatoses: A Benign Masquerader of Malignancies-Is It Really an Advantageous Tool?

Fibromatoses are a heterogeneous group of benign proliferating fibroblasts and myofibroblasts which have a high predilection for recurrence and local invasion, especially deep fibromatoses or desmoid fibromatosis. F-FDG PET/CT, the workhorse of oncological imaging in nuclear medicine, can be employed to figure out the nature and aggressiveness of the lesions and various sites of involvement and to monitor treatment response to systemic therapies like tyrosine kinase inhibitors in case of deep or desmoid fibromatoses which is shown in the current research work.

FDG PET/CT in the Diagnosis and After Sunitinib Follow-up of Synchronous Base of Tongue and Thyroid Metastases From Renal Cell Carcinoma.

Renal cell carcinoma (RCC) is a leading cause of mortality among genitourinary malignancies with limited therapeutic options. The hematogenous route, lymphatic spread, and direct invasion have been documented in RCC. Usually, metastases are regional lymph nodes, lungs, bone, liver, adrenal glands, contralateral kidney, and brain.

Role of Testicular Scintigraphy in the Assessment of Viability of Undescended Testis: Potential Pitfalls and Complementary Role of 18F FDG PET/CT.

Doppler ultrasonography and testicular scintigraphy are sensitive techniques to detect the adequacy of blood flow to testicular tissue. Because Doppler ultrasonography is an operator-dependent imaging modality, it can result in equivocal findings. Testicular scintigraphy proves to be more accurate in such cases, but it may be inconclusive on occasion.