Intracranial and Extracranial Vascular Involvement in Takayasu Arteritis Unresponsive to Multiple Lines of Immunomodulation on 68Ga-FAPI PET/CT: A Game Changer.

Takayasu arteritis (TAK) is a large-vessel vasculitis characterized by granulomatous inflammation of the aorta and its primary branches. The clinical presentation of TAK is heterogeneous. Intracranial vascular involvement in TAK is uncommon and is understudied. Clinical, biochemical, and imaging data always do not correspond, making it difficult to evaluate disease activity in TAK. FAPI PET/CT is a noninvasive whole-body imaging modality that could potentially aid in diagnosis, therapy monitoring, and identifying disease relapse when 18F-FDG-PET/CT is inconclusive. The authors in this research demonstrate intracranial and extracranial vascular involvement in a patient of TAK on 68Ga-FAPI-04 PET/CT.