Role of lifestyle interventions in reducing UTI burden among Individuals with obesity.

Urinary tract infections (UTIs) are a prevalent health concern globally, and their incidence is disproportionately higher among individuals with obesity. Obesity increases the likelihood of UTIs due to a range of physiological, immunological, and behavioural factors. This article explores the relationship between obesity and UTIs while emphasizing evidence-based lifestyle changes to lower this risk.

Renal Barocrinology: The Interface between Obesity and Kidney Health.

Obesity is been acknowledged to be a major risk factor for chronic kidney disease (CKD), contributing to both its onset and progression. Over past few decades, the obesity epidemic has lead to an increased incidence of obesityrelated nephropathy, characterised by glomerular hyperfiltration, hypertrophy, and progressive glomerulosclerosis. This review highlights the need for multidisciplinary action to prevent and manage obesityrelated nephropathy.

Obestasis.

Obestasis, a commonly experienced phenomenon, is the term given to the mild, pitting oedema that is associated with obesity. Obestasis can be due to various disorders, including lymphatic, microcirculatory and venous dysfunction, as well as sarcopenia. It can be worsened by protein deficiency, excessive salt intake, poor physical conditioning, and tight clothing or foot wear.

ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus.

Organ shortage remains a critical challenge in India's transplant landscape, despite established deceased donor organ transplantation (DDOT) programmes. Many potentially viable organs from brain-dead deceased donors (DBDs) are discarded due to uncertainties surrounding donor suitability in specific clinical scenarios. To address this gap, the Indian Society of Organ Transplantation (ISOT) convened a panel of national experts to develop a Delphi consensus statement aimed at guiding transplant professionals on the feasibility of organ donation from DBDs, particularly in complex or marginal donor situations.

Renal Involvement in Primary Sjögren's Syndrome: A Multi-centric Study From North India.

Introduction Renal involvement in primary Sjögren's syndrome is often underdiagnosed and overlooked. There is a lack of substantial data on the renal manifestations and outcomes in these patients. This study aims to stress the importance of thorough evaluation of renal dysfunction in individuals with Sjögren's syndrome to improve their overall health and quality of life.

Effect of miRNA gene polymorphisms on prostate cancer susceptibility: a case-control study and an updated meta-analysis.

Background: Prostate cancer (CaP) is the most commonly diagnosed malignant tumor and the leading cause of cancer-related deaths among men. Due to their potential functional significance, microRNA genes are considered promising candidates for identifying cancer-related genetic biomarkers. This study investigates the association between microRNA-196a2 (rs11614913), microRNA-146a (rs2910164), and microRNA-149 (rs2292832) and the risk of prostate cancer among males in the Jammu region of Jammu and Kashmir (J&K).

Expert Opinion on Management Advancements in Sarcopenia: From Muscle Wasting to Recovery.

Sarcopenia, an age-related condition marked by the decline of skeletal muscle mass, strength, and function, often leads to loss of function, disability, and diminished quality of life (QoL) in the elderly population. Despite its growing prevalence, sarcopenia is frequently underdiagnosed and inadequately managed. Timely detection and appropriate interventions are crucial to slowing disease progression and minimizing associated risks.

Preventing Chronic Kidney Disease: The Role of Community-Based Interventions.

Chronic Kidney Disease (CKD) is a growing public health crisis, driven by the increasing prevalence of metabolic disease. Without timely detection and intervention, CKD can progress to end stage kidney disease, leading to significant morbidity and mortality. In line with the theme of World Kidney Day (WKD) 2025, "Are Your Kidneys OK? Detect Early, Protect Kidney Health," this article explores community-based interventions as a key strategy in preventing CKD.

Electrolyte Inertia In Chronic Kidney Disease.

Electrolyte imbalances are a common and challenging aspect of managing chronic kidney disease (CKD). Despite advances in treatment, a phenomenon known as "electrolyte inertia"- the inertness to correcting abnormal electrolyte levels- may persist in CKD patients. This inertia can result from various factors which include delayed therapeutic intervention, the complexity of multiple coexisting comorbidities, and the judicious balanced therapeutic approach necessitated by the multidyselectrolytaemia in CKD management.

Challenges and Solutions for Transplantation in Northeast India: Proceedings of the National Organ and Tissue Organization Session at the India Society of Organ Transplantation 2023 Meeting in Kolkata.

Background: India is the third highest in terms of the total number of organ transplants in a year worldwide mainly based on living donor transplants. The number of deceased donor transplants has been limited in India ranking only at the 68th position of 94 countries that reported data to Global Observatory on Organ Donation and Transplantation during the year 2022.

Methods: Representatives of National Organ and Tissue Transplant Organisation in addition to local transplant experts from Northeast India and Indian Society of Organ Transplantation discussed challenges and potential solutions for organ transplantation in Northeast India at the National Organ and Tissue Transplant Organisation session during the India Society of Organ Transplantation 2023 annual conference held at Kolkata.

Analysis of Berberine as a Potential Therapeutic Approach for Various Signalling Pathways Linked to Androgenetic Alopecia.

Background: Alopecia is defined by a loss of hair density and is often considered a symptom of multiple illnesses, such as infection and inflammation.

Objective: The molecular mechanisms underlying the hair-promoting effects include inhibition of 5α-reductase activity, reducing the binding affinity of Dihydrotestosterone (DHT) to androgen receptors, and decreasing/down-regulating TGF-β2 activity, which have a suggestive role in androgenetic alopecia. Finasteride and minoxidil are the approved non-surgical treatment alternatives for hair loss, but they cause side effects in patients.

The effect of Polybrominated diphenyl ethers at the fetal blood-brain-barrier: evaluation using a microphysiological system.

Background: Glutamate dysregulation leading to neuronal excitotoxicity and neuroinflammation are associated with neurological disorders, specifically autism spectrum disorders (ASD) in preterm neonates. The lack of physiologically relevant models has limited mechanistic understanding of glutamate dysregulation and neuroinflammation during pregnancy. This study evaluated the effect of environmental pollutant and flame retardant, Polybrominated Diphenyl Ethers (PBDE) 99 and 47, on cell viability, glutamate dysregulation, and neuroinflammation using a microphysiologic system (MPS) of human fetal blood-brain-barrier organ on a chip (FB-OOC).

Optimizing Kidney Disease Management during Ramadan: Evidence-Based Risk Stratification and Tailored Strategies.

Fasting during Ramadan poses distinct challenges for individuals with kidney disease, requiring a careful balance between spiritual commitments and health maintenance. This article combines insights from recent research and guidelines to offer a thorough framework for risk assessment. Patients are classified into low, moderate, and high-risk categories based on individual, environmental, and health-related factors.

One Nation-One Dialysis: Breaking Barriers, Empowering Lives.

The objective of India's One Nation One Dialysis (ONOD) program is to remove the barriers that end-stage kidney disease patients face in accessing consistent, quality dialysis services across the nation. A unified and standardized dialysis care approach is what ONOD aims to achieve at a national level. The objective of ONOD is to improve access to, affordability of, and quality in dialysis services for economically weaker segments of society and those living in remote areas of the country by providing dialysis services through public-private partnerships.

Kidney and Lungs: Do they Cross-talk?

The kidneys and lungs, often studied in isolation, are integral organs in maintaining homeostasis within the human body. However, the lung and kidney have multiple shared physiological and pathological pathways. It is important to understand these complex interactions and the cross-talk to manage patients, especially in critical care.

GALNT3 Mutation in Hyperphosphatemic Familial Tumoral Calcinosis - Novel Etiology of Secondary Amyloidosis.

Tumoral calcinosis is a rare syndrome characterized by calcium salt deposition in different periarticular soft tissue regions. We report this case of tumoral calcinosis with history of persistent soft tissue calcifications for over three decades. He presented with nephrotic syndrome and kidney biopsy revealed secondary amyloidosis.

Impact of La doping on the structural, magnetic, and dielectric properties of Mg-Co ferrites for high-frequency applications.

In this study, the influence of La ion doping on the microstructure, crystallite size, as well as magnetic and dielectric properties of MgCoFeLaO (0 ≤ ≤ 0.1) ferrite nanoparticles is examined. The La ion has a larger ionic radius than the Fe ion and occupies the octahedral site, resulting in the expansion of the crystal lattice.

Is Depression Dialyzable?

Depression is a common and debilitating comorbidity in patients with chronic kidney disease (CKD), particularly those with end-stage kidney disease (ESKD, CKD stage 5). This association stems from a complex interplay of biological and psychosocial factors, including the accumulation of uraemic toxins such as middle molecules, chronic inflammation, and the psychological burden of disease progression. Initiation of dialysis has been observed to alleviate depressive symptoms through multiple mechanisms: removal of uraemic toxins, improvement in physical health, and reduction in psychosocial stressors.

Navigating Hyperkalaemia- The A-to-H Clinical Strategy.

Hyperkalaemia is a life-threatening dyselectrolytaemia which is characterized by elevated serum potassium levels. It needs a systematic and overarching approach to effectively manage a case of hyperkalaemia. We propose a structured A-to-H approach to guide clinicians in managing hyperkalaemia, ensuring that no critical aspect is neglected or inadvertently missed.

Placental alkaline phosphatase (PLAP): Is it exclusively placental?

Background: Adverse pregnancies outcomes present a clinical dilemma in Perinatal medicine. This is partly due to lack of accuracy of current biomarkers to predict high-risk pregnancies at an earlier stage. The placental alkaline phosphatase (PLAP) carrying extracellular vesicles (EVs), and their cargo have been reported as a source of biomarkers for placental health and an indication of pre-eclampsia progression.

Gluconephrotic Syndrome: A Comprehensive Review.

This article provides an overview of the diabetic kidney disease paradigm, explaining important aspects such as prognostic markers, clinical assessments, and therapeutic options. The importance of the term gluconephrotic syndrome (GlucoNS) is emphasized, highlighting its significant influence on clinical evaluations, research procedures, screening techniques, and patient care. This term encapsulates nephrotic syndrome (NS) within the diabetic milieu, shedding light on the intricate relationship between renal complications and diabetes.

Tuberculosis in kidney transplant candidates and recipients.

Tuberculosis (TB) is the leading cause of infectious mortality and morbidity in the world, second only to coronavirus disease 2019. Patients with chronic kidney disease and kidney transplant recipients are at a higher risk of developing TB than the general population. Active TB is difficult to diagnose in this population due to close mimics.