Proteasomes suppress anticancer drug-induced cytotoxicity by inhibiting mitochondrial protein import and promoting ROS-BNIP3-mediated mitophagy.

Multidrug resistance (MDR) is associated with increased proteasome activity, which facilitates the clearance of damaged proteins and reduced mitochondrial activity, which contributes to quiescence. However, the mechanistic link between protein damage, mitochondrial dysfunction, and proteasome activity remains elusive. Here, we demonstrate that chemical drugs bind to newly synthesized mitochondrial proteins, which are largely unfolded and are coimported into the mitochondrion before appearing in the lysosome and/or nucleus.

Exploring gender-related clinical and immunological profiles in Sjögren's disease in a Chinese cohort.

Background: Sjӧgren's disease (SjD) is a complex and heterogeneous disease with female predominance. However, gender-related differences in the clinical and immunological profiles of SjD patients have not been fully explored, especially after adjusting for confounding factors such as age and disease duration. This study aims to investigate these gender-specific differences in a Chinese cohort.

Natural environmental factors at birth on risk for rheumatoid arthritis: the impact of season, temperature, latitude, and sunlight exposure.

Background: Environmental factors contribute to approximately 41% of the risk of rheumatoid arthritis (RA). Previous studies have focused on anthropogenic environmental factors, while much less attention has been given to natural environmental factors. Our study explored the potential influence of natural environmental factors at birth on the risk of RA.

Dietary protein and multiple health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.

Background & Aims: Numerous studies have evaluated the effects of dietary protein on specific health outcomes. The aim of our umbrella review was to summarize the existing evidence between the intake of dietary proteins and multiple health outcomes, and assess their strength and validity.

Methods: Our study was registered at PROSPERO (No.

Long-term PM exposure and various health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.

Adverse effects from exposure to particulate matter <2.5 μm in diameter (PM) on health-related outcomes have been found in a range of experimental and epidemiological studies. This study aimed to assess the significance, validity, and reliability of the relationship between long-term PM exposure and various health outcomes.

Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies.

Background And Aims: The coronavirus disease 2019 (COVID-19) pandemic is severely threatening and challenging public health worldwide. Epidemiological studies focused on the influence of outdoor air pollution (AP) on COVID-19 risk have produced inconsistent conclusions. We aimed to quantitatively explore this association using a meta-analysis.

Air pollution and metabolic syndrome risk: Evidence from nine observational studies.

Background And Aims: Globally, the number of metabolic syndrome (MetS) cases has increased substantially over time. However, the association between air pollution (AP) and MetS risk has been contradictory in observational studies. This is the first reported meta-analysis quantitatively exploring the aforementioned association.

Imaging characteristics of coronavirus disease 2019 (COVID-19) in pediatric cases: a systematic review and meta-analysis.

Background: The confirmed coronavirus disease 2019 (COVID-19) cases, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have exceeded 21 million (with more than 775,000 fatalities), and the number of children with COVID-19 is also increasing. This study aimed to summarize the chest imaging characteristics of pediatric COVID-19 cases and provide a reference for the diagnosis and control of pediatric COVID-19.

Methods: The study protocol was registered in PROSPERO, number CRD42020177391.

Research Progress on Surface Treatments of Biodegradable Mg Alloys: A Review.

Mg alloys have attracted extensive attention in the biomedical fields owing to their great biocompatibility, suitable mechanical properties, and biodegradability, etc. However, the fast degradation rate restricts the application of Mg alloys. Thus, the surface treatment of Mg alloys is considered as one of the most effective ways to enhance the corrosion resistance of Mg alloys.