Long-Term Outcomes of BAV-0 Patients Compared With BAV-1 and TAV Patients After TAVR.

Background: Differences in long-term clinical outcomes following transcatheter aortic valve replacement (TAVR) in different anatomical subtypes of aortic valve stenosis (AS), specifically tricuspid aortic valves (TAV) and bicuspid aortic valves (BAV) of types 0 (BAV-0) and 1 (BAV-1), are not well understood.

Objectives: The authors sought to report and compare the long-term clinical outcomes among patients with different anatomical subtypes of AS undergoing TAVR.

Methods: We conducted an international retrospective cohort study involving patients who underwent TAVR for severe AS at 3 large, high-volume heart centers in China, Germany, and Denmark before October 2018.

Ultrasound-induced modifications in structure, antioxidant activity and functionality of whey protein isolate-propolis polyphenol conjugates.

In this study, whey protein isolate was conjugated with polyphenols via free radical reactions, using ultrasound treatment to enhance the bio-functional properties of the resulting conjugates. Ultrasound at 270 W for 20 min significantly improved the degree of conjugation compared to the traditional free radical method, as evidenced by higher levels of total phenolic and flavonoid content. Structural analysis revealed that the conjugates produced with ultrasound exhibited reduced α-helix content but increased β-turn and random coil structures, along with enhanced fluorescence intensity and surface hydrophobicity.

Benth-Associated Endophytes: A Multifaceted Exploration of Its Bioactive Molecules.

Unlabelled: Endophytes associated with medicinal plants hold substantial promise as a novel source for therapeutics development. In this study, 11 endophytic fungi and 9 endophytic bacteria were isolated from the roots of . In the preliminary screening, the ethyl acetate extract of the FG-Z21 displayed strong inhibitory effects against drug-resistant bacteria and Methicillin-resistant (MRSA) with MIC values of 1.

Temporal trends of transcatheter aortic valve replacement outcomes in a high-volume center from China.

Since the first transcatheter aortic valve replacement (TAVR) was performed in China in 2010, TAVR has developed rapidly. However, the temporal trends in the 1-year prognosis after TAVR in China have not been described. This study enrolled patients treated at a high-volume Chinese TAVR center, West China Hospital, between 2015 and 2022, to analyze and characterize the temporal trends in 1-year outcomes.

Prognostic value of nutritional changes in older patients following transcatheter aortic valve replacement.

Objectives: Nutritional status, as one of the core characteristics of frailty, the impact of its changes on clinical outcomes in older patients following transcatheter aortic valve replacement (TAVR) remains unclear.

Design: A retrospective cohort study.

Setting: This study included a total of 781 patients who underwent TAVR at West China Hospital between 2012 and 2022.

Advanced Cardiac Patches for the Treatment of Myocardial Infarction.

Myocardial infarction is a cardiovascular disease characterized by a high incidence rate and mortality. It leads to various cardiac pathophysiological changes, including ischemia/reperfusion injury, inflammation, fibrosis, and ventricular remodeling, which ultimately result in heart failure and pose a significant threat to global health. Although clinical reperfusion therapies and conventional pharmacological interventions improve emergency survival rates and short-term prognoses, they are still limited in providing long-lasting improvements in cardiac function or reversing pathological progression.

Metagenomic analysis of individual mosquito viromes reveals the geographical patterns and drivers of viral diversity.

Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a meta-transcriptomic approach, we determined the viromes of 2,438 individual mosquitoes (81 species), spanning ~4,000 km along latitudes and longitudes in China.

Optimization of ultrasound-assisted extraction of fatty acids from royal jelly and its effect on the structural and antioxidant property.

Fatty acids are the key active components in royal jelly (RJ) with various biological activities. In this study, a novel ultrasound-assisted extraction (UAE) method was established to extract fatty acids from RJ and their structural and antioxidant property were further evaluated. The optimum extraction conditions were as follows: liquid-to-solid ratio of 10:1, ultrasonic power of 450 W and ultrasonic duration of 20 min, resulting in a better extraction yield of 16.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses.

Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Using a meta-transcriptomic approach, we analysed the virome of 2,438 individual mosquitos (79 species), spanning ~4000 km along latitudes and longitudes in China.

Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR-8/SVneo cells.

The accumulation of cadmium (Cd) in the human body through food chain can lead to adverse pregnancy outcomes. In this study, Cd cytotoxicity and its mechanisms in HTR-8/SVneo cells were investigated. Cd disrupted the cellular submicrostructure and inhibited the cell viability in a time- and dose-dependent manner.

Methylmercury cytotoxicity and possible mechanisms in human trophoblastic HTR-8/SVneo cells.

Methylmercury (MeHg) exposure during pregnancy can lead to adverse outcomes, including miscarriage and intrauterine growth retardation. In this study, MeHg cytotoxicity and its mechanisms in HTR-8/SVneo cells were investigated. MeHg inhibited HTR-8/SVneo cell viability and severely disrupted the cellular submicrostructure, showing a time-dose effect relationship.

Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes.

The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds.