Publications by authors named "Shaoyi Su"
Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective therapy for Parkinson's disease (PD). However, the therapeutic mechanisms remain incompletely understood, particularly regarding the extracellular space (ECS), a critical microenvironment where molecular diffusion and interstitial fluid (ISF) dynamics are essential for neural function. This study aims to explore the regulatory mechanisms of the ECS in the substantia nigra (SN) of PD rats following STN-DBS.
View Article and Find Full Text PDFNeurochemical imbalance is a contributing factor to neurological symptoms in multiple sclerosis (MS). The matured myelin sheath is crucial for substance transportation within the extracellular space (ECS) and for maintaining local homeostasis. Therefore, we hypothesize that disturbed ECS transportation following demyelinating lesions might lead to neurochemical imbalance in MS.
View Article and Find Full Text PDFFunctional Connectivity Encodes Sound Locations by Lateralization Angles.
Neurosci Bull
February 2025
Article Synopsis
- - The study examines how the brain processes sound location through a specific auditory "where" pathway, revealing that regions in this pathway react to sounds from opposite sides of the body through opponent hemifield coding.
- - Researchers used functional magnetic resonance imaging (fMRI) while participants passively listened to sounds coming from five different horizontal angles to analyze the functional connectivity patterns in the auditory pathway.
- - The findings suggest that sound location is represented not just by brain activation patterns but also through the angles of sound lateralization, with connections between visual and auditory regions contributing to this representation.
A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid.
Sci China Life Sci
October 2024
Article Synopsis
- * A new modified method, called m-EAI, effectively speeds up the drainage of interstitial fluid and reduces harmful inflammatory substances in the brain following a stroke.
- * Results from a study using a rat model show that m-EAI led to lower levels of key inflammatory markers and improved outcomes in terms of brain damage and recovery, suggesting it could be a promising strategy for treatment alongside other neuroprotective therapies.
The brain extracellular space (ECS), an irregular, extremely tortuous nanoscale space located between cells or between cells and blood vessels, is crucial for nerve cell survival. It plays a pivotal role in high-level brain functions such as memory, emotion, and sensation. However, the specific form of molecular transport within the ECS remain elusive.
View Article and Find Full Text PDFConditioned nausea induced by cisplatin and emetine identified by a taste reactivity test in rats.
Physiol Behav
October 2023
No prior studies have shown that gaping reactions are produced with the avoidance of conditioned taste caused by cisplatin and emetine. Therefore, we tried to demonstrate it using a taste reactivity test in rats and found the gaping reactions induced when saccharin is readministered after gustatory conditioning that paired saccharin with cisplatin or emetine. Since conditioned gaping reactions indicate the aversion to saccharin taste and conditioned nausea, the present study suggest that the taste aversion is induced by cisplatin and emetine.
View Article and Find Full Text PDFConditioned taste aversion (CTA) is established by pairing a taste solution as a conditioned stimulus (CS) with visceral malaise as an unconditioned stimulus (US). CTA decreases the taste palatability of a CS. The bed nucleus of the stria terminalis (BNST) receives taste inputs from the brainstem.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how lesions in the area postrema and selective vagotomy of afferent fibers affect nausea caused by emetine in rats.
- Rats were conditioned to avoid a 0.1% saccharin solution after being injected with emetine, with three groups being tested: one with afferent vagotomy, one with area postrema lesions, and a control group.
- Results showed that the control and vagotomy groups developed taste avoidance quickly, while the area postrema lesion group did not acquire any taste avoidance, highlighting the area postrema's critical role in nausea induction.
Objectives: The aim of the present study was to demonstrate the effective dose of emetine for inducing nausea and/or emesis, and the effects of emetine on the excitability of central neurons in the area postrema (AP) and the nucleus tractus solitarius (NTS).
Methods: Rats were used as experimental animals. We measured the conditioned taste aversion (CTA) induced by the intraperitoneal administration of emetine solution (0.