Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
No prior studies have shown that gaping reactions are produced with the avoidance of conditioned taste caused by cisplatin and emetine. Therefore, we tried to demonstrate it using a taste reactivity test in rats and found the gaping reactions induced when saccharin is readministered after gustatory conditioning that paired saccharin with cisplatin or emetine. Since conditioned gaping reactions indicate the aversion to saccharin taste and conditioned nausea, the present study suggest that the taste aversion is induced by cisplatin and emetine. It was also found that with intraperitoneal injections of emetine alone, gaping almost never occurs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.physbeh.2023.114278 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral squamous cell carcinoma cancer stem cells have different drug sensitive to pharmacological NFκB and histone deacetylation inhibition.
Am J Cancer Res
December 2023
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas Piracicaba, SP, Brazil.
Article Synopsis
- * Studies indicate that cancer stem cells (CSCs) in OSCC exhibit resistance to CDDP, leading researchers to explore new therapeutic approaches targeting these cells.
- * The research assessed the effects of the NFκB inhibitor emetine and the HDAC inhibitor SAHA on OSCC CSCs, showing that both inhibitors can disrupt these resistant cells by enhancing histone acetylation and inhibiting the NFκB pathway, with combined treatment yielding similar results to emetine alone.
Up-regulation of TNF-alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma.
J Cell Physiol
February 2024
Department of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Tumor resistance remains an obstacle to successfully treating oral squamous cell carcinoma (OSCC). Cisplatin is widely used as a cytotoxic drug to treat solid tumors, including advanced OSCC, but with low efficacy due to chemoresistance. Therefore, identifying the pathways that contribute to chemoresistance may show new possibilities for improving the treatment.
View Article and Find Full Text PDFConditioned nausea induced by cisplatin and emetine identified by a taste reactivity test in rats.
Physiol Behav
October 2023
Oral Physiology, Department of Oral Functional Science, Division of Oral Medical Science, Faculty of Dental Medicine and Graduate school of Dental Medicine, Hokkaido University, Japan. Electronic address:
No prior studies have shown that gaping reactions are produced with the avoidance of conditioned taste caused by cisplatin and emetine. Therefore, we tried to demonstrate it using a taste reactivity test in rats and found the gaping reactions induced when saccharin is readministered after gustatory conditioning that paired saccharin with cisplatin or emetine. Since conditioned gaping reactions indicate the aversion to saccharin taste and conditioned nausea, the present study suggest that the taste aversion is induced by cisplatin and emetine.
View Article and Find Full Text PDFRepurposing NFκB and HDAC inhibitors to individually target cancer stem cells and non-cancer stem cells from mucoepidermoid carcinomas.
Am J Cancer Res
April 2023
Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry Ann Arbor, Michigan, USA.
Article Synopsis
- Drug resistance in mucoepidermoid carcinomas (MEC) leads to issues like tumor recurrence and metastasis, primarily driven by cancer stem cells (CSCs).
- Previous research indicated that tumors use NFkB signaling for chemotherapy resistance, and targeting the epigenome can help manage CSC populations.
- The study found that using low doses of NFkB inhibitor emetine and HDAC inhibitor SAHA is effective against MEC CSCs; also, combining emetine with Cisplatin (CDDP) is a promising strategy for treating the non-CSC tumor cells in MEC.
Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinoma.
Commun Biol
January 2023
Oncogenetics, Dept. of Human Genetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, Netherlands.
Fanconi anaemia (FA) is a rare chromosomal-instability syndrome caused by mutations of any of the 22 known FA DNA-repair genes. FA individuals have an increased risk of head-and-neck squamous-cell-carcinomas (HNSCC), often fatal. Systemic intolerance to standard cisplatin-based protocols due to somatic-cell hypersensitivity underscores the urgent need to develop novel therapies.
View Article and Find Full Text PDF