Ameloblastic fibrosarcoma in adolescence: A rare case of a malignant odontogenic tumor.

A female patient, 15 years old, presented to the primary health unit with a complaint of vestibular and lingual swelling in the mandibular region, with a duration of 5 months. Imaging analysis revealed a destructive lesion with poorly defined margins. After an incisional biopsy, the lesion showed expansive and rapid growth.

Experimental assessment of photodynamic therapy effects on 4NQO-induced rat tongue carcinogenesis: Clinical, morphological, and immunohistochemical analysis.

The present study aimed to evaluate the safety of photodynamic therapy (PDT) during oral carcinogenesis using a 4-nitroquinoline 1-oxide (4NQO) rat model, which serves as a surrogate for tobacco-induced oral cancer. Forty male Wistar rats received 4NQO (25 ppm) in drinking water for either 12 or 20 weeks to induce oral lesions. Animals were divided into two groups: Control and PDT.

Deciphering NOTCH1 as a Biomarker in Adenoid Cystic Carcinoma: Insights From a Systematic Review With Meta-Analysis.

Background: Most studies suggest that NOTCH1 alterations are associated with prognosis in adenoid cystic carcinoma (ACC), but findings remain fragmented. We conducted an integrative analysis to evaluate the prognostic value of NOTCH1-related biomarkers in ACC.

Methods: A comprehensive search was conducted across multiple databases.

Validation of Current Staging Systems in HNCSCC: A Multinational Cohort Study.

Importance: Risk stratification of cutaneous squamous cell carcinoma (CSCC) is central to effective management. Despite advancements in the 8th edition of the American Joint Committee on Cancer (AJCC8) staging system, the distinctiveness of T-stages remains limited.

Objective: To evaluate the effectiveness of the Brigham and Women's Hospital (BWH) and the AJCC8 staging systems in predicting poor outcomes in head and neck (HN) CSCC.

Non-Profit Organizations Advocating for Head and Neck Cancer Patients: A Scoping Review.

Purpose: To identify and characterize non-profit organizations (NPOs) from English-speaking countries providing advocacy to individuals with head and neck cancer (HNC) and critically analyze the multifaceted roles played by these NPOs for patients, caregivers, healthcare professionals, and researchers.

Methods: A scoping review was conducted through PubMed, Scopus, EMBASE, Web of Science, Google Scholar, ProQuest, and open databases. The data collected on the NPOs were: information on origin, founder background, cancer types addressed, mission, and information and services offered.

Germline Variations in Patients With Oral Squamous Cell Carcinoma-Systematic Review.

Objective: Integrate studies on germline variations (GV) in patients with oral squamous cell carcinoma (OSCC), aiming to assess the highest frequencies of which genes were altered in patients with this diagnosis.

Methods: An electronic search was conducted in four databases and in the gray literature, following the PRISMA 2020 recommendations. Case reports, case series, case-control studies, cross-sectional studies, prospective cohort studies, and retrospective cohort studies reporting GV in patients with OSCC were included for data extraction.

Blue Nevus of The Palate: A Case Image.

A 54-year-old female patient was referred to the oral surgery department of a public university with a complaint of a dark spot on the palate that had been present for eight months. Clinical examination revealed a well-circumscribed, darkly pigmented macule measuring approximately 1.5 cm × 1 cm located in the posterior hard palate.

Intraoral Basal Cell Carcinoma: Controversies and Insights From a Systematic Review.

Background: The existence of intraoral basal cell carcinoma (IOBCC) remains controversial, despite reported cases in the literature.

Materials And Methods: A systematic search of four electronic databases and grey literature was conducted. Strict inclusion criteria were established to define a true case of IOBCC, including Ber-EP4 positivity to distinguish it from peripheral ameloblastoma and the absence of a history of skin lesions-either nearby, which could indicate direct infiltration, or at distant sites, which could suggest metastasis rather than a true primary IOBCC.

Oral histiocytic sarcoma: A case report and literature review.

Histiocytic sarcoma (HS) is a rare and aggressive malignancy derived from mature histiocytes, accounting for less than 1% of hematologic disorders. Clinically, HS varies from localized disease with a solitary mass to disseminated disease, often associated with other hematolymphoid neoplasms. Its aggressive nature results in poor outcomes, with a median survival of six months in disseminated cases.

Shedding light on Brazil's contribution to photobiomodulation research in oral medicine: a bibliometric study.

The aim of this study was to verify the role of Brazilian researchers in publications related to photobiomodulation (PBM) in the field of oral medicine. We examined ten years from 2012 to 2022 across 16 journals. Our analysis included scientific publications with a Brazilian author either in the first or last position and publications from international collaborations.

Oral adverse effects of head and neck radiotherapy with/without chemotherapy in a southern Brazil hospital.

The aim of this study was to evaluate the main oral adverse effects and their relationship with dental care before radiotherapy (RT) and combined RT and chemotherapy (RT+CT). Additionally, we assessed the association of other risk factors with the development of these adverse effects. This paper is a retrospective cross-sectional analytical study of data from medical records of patients with head and neck cancer (HNC) who underwent RT or RT+CT attended at the stomatology unit in a southern Brazil hospital.

Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model.

The present investigation aimed to assess the safety of photobiomodulation (PBM) on the oral carcinogenesis process induced by 4NQO, focusing on cell proliferation and apoptosis. Sixty-six Wistar rats received systemic 4NQO for 12 (n = 33) and 20 weeks (n = 33), divided into Control group, PBM 0.3 J, and PBM 1 J.

Second Events After Curative-Intent Treatment for Lip Cancer: Navigating the Path of Follow-Up Care.

Objective: We aimed to investigate the pattern, risk, and treatment of subsequent events after curative-intent treatment of lip cancer.

Methods: This retrospective cohort study included 313 patients treated for lip cancer from 2011 to 2021 in a tertiary oncological center.

Results: After a median follow-up time of 29.

Disruption of oncogenic pathways in mucoepidermoid carcinoma: CREB inhibitor 666.15 as a potential therapeutic agent.

Objectives: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour with around 50 % of cases carrying the CRTC1-MAML2 translocation. The CREB pathway has been associated with the transforming activity of this translocation. The aim of this study was to determine the effects of CREB inhibition on MEC cell behaviour in vitro.

Pleomorphic adenoma and carcinoma ex-pleomorphic adenoma tumorigenesis: A proteomic analysis.

Objectives: To conduct a comprehensive proteomic analysis of normal salivary gland tissue, pleomorphic adenoma (PA), and carcinoma ex-pleomorphic adenoma (CXPA), and validate the proteomic findings using immunohistochemistry.

Methods: Six normal salivary gland tissues, seven PA and seven CXPA samples underwent laser microdissection followed by liquid chromatography coupled to mass spectrometry. Protein identification and quantification were performed using MaxQuant software.

Modulation of gene expression in skin wound healing by photobiomodulation therapy: A systematic review in vivo studies.

Background: Wound healing is a multistep process involving coordinated responses of a variety of cell types, cytokines, growth factors, and extracellular matrix (ECM) components leading to the physiological restoration of tissue integrity. Photobiomodulation therapy (PBMT) has been highlighted as an approach to improve the healing process, nonetheless at the molecular level, the effects of PBMT are not entirely understood.

Aim: To systematically review publications that investigated gene expression after PBMT during in vivo skin repair.

Impact of photobiomodulation for prevention of oral mucositis on the quality of life of patients with head and neck cancer: a systematic review.

The aim of this study was to perform a systematic review to evaluate the impact of photobiomodulation therapy (PBMT) for the prevention of oral mucositis (OM) on the quality of life (QoL) of patients with head and neck cancer (HNC) undergoing radiation therapy. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The search strategy was performed in five electronic databases (Cochrane, Embase, PubMed, Scopus, and Web of Science).

Virtual learning object about oral ulcerative lesions: controlled educational intervention study.

The aim of this study was to develop a virtual learning object (VLO) to teach undergraduate dental students about the diagnostic and therapeutic approaches to oral ulcerative lesions. The VLO was developed with information on the diagnostic process, lesion classification, and clinical-surgical management of oral ulcerative lesions. The VLO content was initially validated by a group of specialists.

Ewing's sarcoma of the head and neck: A systematic review.

Objective: The aim of the present study was to conduct a systematic review of head and neck Ewing sarcoma (ES) concerning patients' demographic and clinical features, histopathological findings, treatment, follow-up, and survival rate.

Materials And Methods: An electronic search was undertaken in four databases. Articles describing case reports or case series were included.

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study.

The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information.

Foreign body reactions related to orofacial esthetic fillers: A systematic review.

The aim of this study was to systematically review the clinicopathological data regarding foreign body reactions (FBR) related to esthetic procedures in the orofacial region. Electronic searches were performed in six databases and in gray literature using PEO acronym for the review question. Case series and case reports describing FBR related to esthetic procedures in the orofacial region were included.