98%
921
2 minutes
20
A 54-year-old female patient was referred to the oral surgery department of a public university with a complaint of a dark spot on the palate that had been present for eight months. Clinical examination revealed a well-circumscribed, darkly pigmented macule measuring approximately 1.5 cm × 1 cm located in the posterior hard palate. The lesion's location and size raised suspicion of malignancy. An incisional biopsy was performed, and histopathological analysis showed the presence of spindle cells containing light brown pigmented granules compatible with melanin. The final diagnosis was of blue nevus. The lesion was surgically excised, with satisfactory healing, and a follow-up period of 5 months. Blue nevus is a melanocytic lesion that typically presents as a small pigmented spot and is rare in the oral cavity. This case is notable due to the lesion's size and location and overlapping features commonly associated with malignancy, posing a diagnostic challenge, particularly for pathologists who infrequently review melanocytic lesions. This highlights the critical role of histopathological analysis in establishing a definitive diagnosis. Additionally, careful clinical follow-up is essential to monitor healing and detect any potential recurrence.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209113 | PMC |
http://dx.doi.org/10.1007/s12105-025-01821-y | DOI Listing |
Cureus
July 2025
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ioannina, Ioannina, GRC.
Metastatic melanoma to the parotid gland is rare and represents a significant diagnostic challenge due to its atypical presentation, often resembling benign conditions, resulting in delays in diagnosis. Early and accurate detection is crucial for optimizing patient outcomes. We report the case of a 27-year-old woman who presented with a slowly growing, painless mass in her right parotid gland, which had been enlarging over the past three months.
View Article and Find Full Text PDFExp Dermatol
August 2025
The Kittner Skin Cancer Screening & Research Institute, Sheba Medical Center, Ramat Gan and School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Negative pigment network (NPN) is a dermoscopic structure frequently associated with melanoma. Though commonly observed in Spitz naevi (SN) and Spitzoid melanoma (SM), its reflectance confocal microscopy (RCM) correlates have been primarily studied in non-Spitzoid melanocytic neoplasms. This study aimed to identify clinical, dermoscopic, and RCM features associated with dermoscopic NPN in Spitzoid neoplasms and explore its histopathological correlates.
View Article and Find Full Text PDFJ Ultrasound
August 2025
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
Angiomas and blue nevi are common benign skin lesions with overlapping clinical appearances that can mimic malignancy, such as melanoma. This study evaluates the role of dermoscopy-assisted high-frequency ultrasound (DA-HFUS) in characterizing these lesions. Five cases (2 angiomas, 3 blue nevi) were examined using the Dermus SkinScanner, a handheld 33 MHz device with integrated optical guidance.
View Article and Find Full Text PDFAm J Dermatopathol
August 2025
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, NY.
Background: The 23-gene expression signature (GES) assay (myPath Melanoma) is a well-established molecular test for analyzing challenging melanocytic lesions, alongside fluorescence in situ hybridization (FISH) and single nucleotide polymorphism (SNP) array. However, routine use of these tests is often limited by high costs, long turnaround times, significant tissue requirements, and limited accessibility. This study aimed to evaluate the diagnostic concordance of PRAME immunohistochemistry (IHC) and the GES assay in difficult melanocytic lesions to determine whether PRAME IHC, widely available in pathology laboratories, could serve as a surrogate for GES.
View Article and Find Full Text PDFReports (MDPI)
August 2025
Department of Plastic Surgery and Burns Treatment, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
: Osteonevus of Nanta is a rare histological phenomenon characterized by bone formation within a benign melanocytic nevus, most commonly in intradermal nevi of the head and neck. Although osteonevus of Nanta is rare, ossification in a cellular blue nevus is even more uncommon. To date, only one case of a cellular blue nevus with ossification has been documented.
View Article and Find Full Text PDF