Rational Molecular Design of π-Extended Thiazolothiazole for High-Performance UV-OPDs Seamlessly Integrated with CMOS.

Vacuum-deposited organic photodiodes (OPDs) offer unique advantages-including narrowband selectivity and compatibility with standard fabrication processes-but achieving ultraviolet (UV) selectivity in such devices remains a key challenge. This is due to the need to reconcile two competing design requirements: 1) strong π-π stacking for efficient charge transport, and 2) limited π-conjugation to retain a wide bandgap suitable for UV absorption and vacuum deposition. Here, we report a molecular design strategy for UV-selective OPDs based on thiazolothiazole (Tz)-based small molecules with tailored backbone planarity and conjugation length.

Therapeutic effects of miR-937-3p by targeting NTN1 expression and regulating apoptosis in an Aβ-induced neuronal cell death.

MicroRNAs (miRNAs) have multiple functions that regulate gene expression in various species. Few studies have explored the effects of miRNAs on the pathogenesis of Alzheimer's disease (AD); however, the potential neuroprotective effects of miRNAs on AD, particularly by targeting neuronal markers, remain unclear. In this study, we suggested potential neuroprotective roles for miR-937-3p in an in vitro AD model, which has not been extensively studied.

Kinematics and aerodynamics of in-flight drinking in bats.

Bats, the only mammals with powered flight, provide inspiration to engineer highly manoeuvrable flapping wing aerial vehicles due to their ability in performing several complex manoeuvres. While straight flight manoeuvres have been extensively studied, drinking flight manoeuvres have not. We have studied two insectivorous bat species in terms of wing kinematics and aerodynamics during drinking flight: and .

Macropore absorbent with bihydrophilic layers for the recovery of low-sulfur fuel oil.

Conventional absorbent pads are widely employed for oil spill cleanup; however, their microporous structures face challenges in absorbing low-sulfur fuel oil (LSFO), especially at lower temperatures when LSFO solidifies owing to its high-viscosity shear stress. In this study, we developed a macroporous absorbent with bihydrophilic layers (MABL), i.e.

Tm4sf19 inhibition ameliorates inflammation and bone destruction in collagen-induced arthritis by suppressing TLR4-mediated inflammatory signaling and abnormal osteoclast activation.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and abnormal osteoclast activation, leading to bone destruction. We previously demonstrated that the large extracellular loop (LEL) of Tm4sf19 is important for its function in osteoclast differentiation, and LEL-Fc, a competitive inhibitor of Tm4sf19, effectively suppresses osteoclast multinucleation and prevent bone loss associated with osteoporosis. This study aimed to investigate the role of Tm4sf19 in RA, an inflammatory and abnormal osteoclast disease, using a mouse model of collagen-induced arthritis (CIA).

Hierarchically-structured ratchet skimmer with superhydrophilicity for continuous recovery of high-viscosity oil.

Oil spill accidents have series environmental and economic impacts, increasing the demand for efficient technologies to recover oil from contaminated waters. In this study, a hierarchically structured ratchet surface with superhydrophilicity was presented as a novel oil skimming mechanism for the recovery of high-viscosity oil, particularly low-sulfur fuel oil (LSFO), which has recently been used as marine fuel in open water environments. The interaction between the superhydrophilic ratchet and oil provides favorable conditions for oil retention at the water surface.

Monitoring Multiple Behaviors in Beef Calves Raised in Cow-Calf Contact Systems Using a Machine Learning Approach.

The monitoring of pre-weaned calf behavior is crucial for ensuring health, welfare, and optimal growth. This study aimed to develop and validate a machine learning-based technique for the simultaneous monitoring of multiple behaviors in pre-weaned beef calves within a cow-calf contact (CCC) system using collar-mounted sensors integrating accelerometers and gyroscopes. Three complementary models were developed to classify feeding-related behaviors (natural suckling, feeding, rumination, and others), postural states (lying and standing), and coughing events.

Comparison of the Short Time Effect of an Oral Hygiene Education in Four Sessions via Quantitative Light-Induced Fluorescence Technology Versus Disclosing Agents in Children: A Randomized, Crossover Clinical Trial.

Objectives: The aim of this study is to compare the effectiveness of Qscan plus™ (AIOBIO, Seoul, Korea) based on quantitative light-induced fluorescence (QLF) technology and disclosing agents in oral health programs in children.

Methods: A randomized crossover study was conducted for Korean children aged 6-11 years. Fifty-eight participants (29 to use Qscan plus™ first and 29 to use the disclosing agent first) were enrolled in this study.

Capillary Skimming of Floating Microplastics via a Water-Bridged Ratchet.

Floating microplastics (MPs) have recently become a major concern in marine pollution; however, current filter-based technology is hardly effective for directly removing such MPs from the water surface because of specific mesh size and clogging issues. This paper introduces a new skimming concept for removing floating MPs utilizing capillary force mediated by the elevation of a hydrophilic ratchet at the air-water interface. MPs floating near the ratchet surface are spontaneously forced toward the ratchet with a concave water meniscus, driven by the Cheerios effect.

A sexually transmitted sugar orchestrates reproductive responses to nutritional stress.

Seminal fluid is rich in sugars, but their role beyond supporting sperm motility is unknown. In this study, we found Drosophila melanogaster males transfer a substantial amount of a phospho-galactoside to females during mating, but only half as much when undernourished. This seminal substance, which we named venerose, induces an increase in germline stem cells (GSCs) and promotes sperm storage in females, especially undernourished ones.

The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial.

Functional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov.

High-throughput drug screening using a library of antibiotics targeting cancer cell lines that are resistant and sensitive to gemcitabine.

Gemcitabine is a nucleoside analog widely used as an anticancer agent against several types of cancer. Although gemcitabine sometimes shows excellent effectiveness, cancer cells are often poorly responsive to or resistant to the drug. Recently, specific strains or dysbiosis of the human microbiome were correlated with drug reactivity and resistance acquisition.

MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.

The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Developing mouse incisors allows inspection of the role of the stem cell niche to provide specific insights into essential developmental phases. Microtubule-associated serine/threonine kinase family member 4 (Mast4) knockout (KO) mice showed abnormal incisor development with low hardness, as the size of the apical bud was decreased and preameloblasts were shifted to the apical side, resulting in amelogenesis imperfecta.

A Low-Noise Low-Power 0.001Hz-1kHz Neural Recording System-on-Chip With Sample-Level Duty-Cycling.

Advances in brain-machine interfaces and wearable biomedical sensors for healthcare and human-computer interactions call for precision electrophysiology to resolve a variety of biopotential signals across the body that cover a wide range of frequencies, from the mHz-range electrogastrogram (EGG) to the kHz-range electroneurogram (ENG). Existing integrated wearable solutions for minimally invasive biopotential recordings are limited in detection range and accuracy due to trade-offs in bandwidth, noise, input impedance, and power consumption. This article presents a 16-channel wide-band ultra-low-noise neural recording system-on-chip (SoC) fabricated in 65nm CMOS for chronic use in mobile healthcare settings that spans a bandwidth of 0.

Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.

Background: Multinucleation is a hallmark of osteoclast formation and has a unique ability to resorb bone matrix. During osteoclast differentiation, the cytoskeleton reorganization results in the generation of actin belts and eventual bone resorption. Tetraspanins are involved in adhesion, migration and fusion in various cells.

N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer.

KIAA1324 is a transmembrane protein largely reported as a tumor suppressor and favorable prognosis marker in various cancers, including gastric cancer. In this study, we report the role of N-linked glycosylation in KIAA1324 as a functional post-translational modification (PTM). Loss of N-linked glycosylation eliminated the potential of KIAA1324 to suppress cancer cell proliferation and migration.

Vactosertib, a novel TGF-β1 type I receptor kinase inhibitor, improves T-cell fitness: a single-arm, phase 1b trial in relapsed/refractory multiple myeloma.

Functional blockade of the transforming growth factor-beta (TGF-β) signaling pathway improves the efficacy of cytotoxic and immunotherapies. We conducted a phase 1b study to determine the safety, efficacy, and maximal tolerated dose (200 mg po bid) of the potent, orally-available TGF-β type I receptor kinase inhibitor vactosertib in relapsed and/or refractory multiple myeloma patients who had received ≥2 lines of chemoimmunotherapy. Vactosertib combined with pomalidomide was well-tolerated at all doses, had a manageable adverse event profile and induced durable responses with 80% progression-free survival (PFS-6) at 6 months, while pomalidomide alone historically achieved 20% PFS-6.

SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata.

Background: Silent information regulator 1 (SIRT1), a type III histone deacetylase, is involved in various cutaneous and systemic autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. However, little is known about the role of SIRT1 in the development of alopecia areata (AA).

Objectives: This study investigated whether SIRT1 regulates the hair follicle immune system and is involved in AA pathogenesis.

Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation.

The signaling pathways governing acetaminophen (APAP)-induced liver injury have been extensively studied. However, little is known about the ubiquitin-modifying enzymes needed for the regulation of APAP-induced liver injury. Here, we examined whether the Pellino3 protein, which has E3 ligase activity, is needed for APAP-induced liver injury and subsequently explored its molecular mechanism.