Distinct cerebral amyloid angiopathy patterns in adult Down syndrome.

Introduction: Cerebral amyloid angiopathy (CAA) is an important component of the neuropathology of adult Down syndrome (DS); however, there is a paucity of its systematic in-depth analysis.

Materials And Methods: Eleven adult DS cases were analyzed for the presence, type, severity (Vonsattel grade), extension (Love grade), and advancement (Thal stage) of CAA using amyloid-beta immunohistochemistry. Hemorrhagic and iron pathologies were assessed by Perls staining, with double-stainings for co-localization.

Facilitators, barriers, and future direction of high-fidelity simulation in nursing education: a qualitative descriptive study.

Background: As simulation-based education has emerged as a crucial alternative for developing integrated practical skills in a safe environment, several foundations have been established in recent years. Now that simulation education has become more established, researchers have identified the need to explore the barriers, facilitators, and future directions of high-fidelity simulation education. The purpose of this study was to enhance our understanding of the barriers and strategies in utilizing high-fidelity simulation in nursing education, specifically regarding its facilitators, barriers, and future directions from the perspective of a nursing educator.

Conformal CEI formation induced by oxygen-functionalized conductive agents on Mn-rich olivine cathodes.

LiMnFePO (LMFP, 0 < < 1) suffers from low electronic conductivity and Mn dissolution. Reduced graphene oxide (rGO) improves electronic conductivity and acts as a sacrificial oxygen source, enabling conformal CEI formation oxidation of surface functional groups, thereby enhancing the interfacial stability and cycling performance of LMFP electrodes.

The potential of proteomics for in-depth molecular investigations of progressive supranuclear palsy.

Introduction: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder. The lack of comprehension about the pathogenesis of the disease, its heterogeneity, and the complex clinical evaluation in early stages, limit the development of effective treatments for PSP patients and highlight the need of further research on the field.

Areas Covered: In this work, we review the current knowledge of the physio- and neuropathology of PSP, its clinical features, diagnosis markers, and treatment options.

Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy.

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by four-repeat (4R) tau protein deposition. The substantia nigra (SN) and midbrain tegmentum nuclei (MBT) are consistently affected. Lymphocyte infiltrates are scarce in the brains of patients with neurodegenerative diseases, although a few reports have described their presence in the α-synucleinopathy Parkinson's disease (PD).

Ageing-related tau astrogliopathy severely affecting the substantia nigra.

Aims: Astrocytic tau pathology is a major feature of tauopathies and ageing-related tau astrogliopathy (ARTAG). The substantia nigra (SN) is one of the important degenerative areas in tauopathies with parkinsonism. Nigral tau pathology is usually reported as neuronal predominant with less prominent astrocytic involvement.

The importance of prion research.

Over the past four decades, prion diseases have received considerable research attention owing to their potential to be transmitted within and across species as well as their consequences for human and animal health. The unprecedented nature of prions has led to the discovery of a paradigm of templated protein misfolding that underlies a diverse range of both disease-related and normal biological processes. Indeed, the "prion-like" misfolding and propagation of protein aggregates is now recognized as a common underlying disease mechanism in human neurodegenerative disorders such as Alzheimer's and Parkinson's disease, and the prion principle has led to the development of novel diagnostic and therapeutic strategies for these illnesses.

SNCA and TPPP transcripts increase in oligodendroglial cytoplasmic inclusions in multiple system atrophy.

Multiple system atrophy (MSA) is characterized by glial cytoplasmic inclusions (GCIs) containing aggregated α-synuclein (α-syn) in oligodendrocytes. The origin of α-syn accumulation in GCIs is unclear, in particular whether abnormal α-syn aggregates result from the abnormal elevation of endogenous α-syn expression in MSA or ingested from the neuronal source. Tubulin polymerization promoting protein (TPPP) has been reported to play a crucial role in developing GCI pathology.

Cellular iron deposition patterns predict clinical subtypes of multiple system atrophy.

Background: Multiple system atrophy (MSA) is a primary oligodendroglial synucleinopathy, characterized by elevated iron burden in early-affected subcortical nuclei. Although neurotoxic effects of brain iron deposition and its relationship with α-synuclein pathology have been demonstrated, the exact role of iron dysregulation in MSA pathogenesis is unknown. Therefore, advancing the understanding of iron dysregulation at the cellular level is critical, especially in relation to α-synuclein cytopathology.

The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases.

Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha-synuclein, and TDP-43. Accumulating evidence supports the contribution of iron in disease pathologies, but the delineation of its pathogenic role is yet challenged by the complex involvement of iron in multiple neurotoxicity mechanisms and evidence supporting a reciprocal influence between accumulation of iron and protein pathology.

Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin-Proteasome Pathways in Lewy Body Disease.

Lewy body diseases (LBDs) feature α-synuclein (α-syn)-containing Lewy bodies, with misfolded α-syn potentially propagating as seeds. Using a seeding amplification assay, we previously reported distinct α-syn seeding in LBD cases based on the area under seeding curves. This study revealed that LBD cases showing different α-syn seeding kinetics have distinct proteomics profiles, emphasizing disruptions in mitochondria and lipid metabolism in high-seeder cases.

Toward Digital Twin Development for Implant Placement Planning Using a Parametric Reduced-Order Model.

Real-time stress distribution data for implants and cortical bones can aid in determining appropriate implant placement plans and improving the post-placement success rate. This study aims to achieve these goals via a parametric reduced-order model (ROM) method based on stress distribution data obtained using finite element analysis. For the first time, the finite element analysis cases for six design variables related to implant placement were determined simultaneously via the design of experiments and a sensitivity analysis.

Neuronal SNCA transcription during Lewy body formation.

Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in familial Parkinson's disease. A contradictory concept proposes early loss of the physiological α-syn as the major driver of neurodegeneration. There is a paucity of data on SNCA transcripts in various α-syn immunoreactive cytopathologies.

Distinct involvement of the cranial and spinal nerves in progressive supranuclear palsy.

The most frequent neurodegenerative proteinopathies include diseases with deposition of misfolded tau or α-synuclein in the brain. Pathological protein aggregates in the PNS are well-recognized in α-synucleinopathies and have recently attracted attention as a diagnostic biomarker. However, there is a paucity of observations in tauopathies.

4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy.

Progressive Supranuclear palsy (PSP) is a 4-repeat (4-R) tauopathy. We hypothesized that the molecular diversity of tau could explain the heterogeneity seen in PSP disease progression. To test this hypothesis, we performed an extensive biochemical characterisation of the high molecular weight tau species (HMW-Tau) in 20 different brain regions of 25 PSP patients.

Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer's Disease Associated with Down Syndrome.

Limited comparative data exist on the molecular spectrum of amyloid-beta (Aβ) and tau deposition in individuals with Down syndrome (DS) and sporadic Alzheimer's disease (sAD). We assessed Aβ and tau deposition severity in the temporal lobe and cerebellum of ten DS and ten sAD cases. Immunohistochemistry was performed using antibodies against eight different Aβ epitopes (6F/3D, Aβ, Aβ, Aβ, Aβ, Aβ, pyroglutamate Aβ at third glutamic acid (Aβ), phosphorylated- (p-)Aβ at 8th serine (Aβ)), and six different pathological tau epitopes (p-Ser202/Thr205, p-Thr231, p-Ser396, Alz50, MC1, GT38).

Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy.

Microtubule-associated protein tau (MAPT) aggregates in neurons, astrocytes and oligodendrocytes in a number of neurodegenerative diseases, including progressive supranuclear palsy (PSP). Tau is a target of therapy and the strategy includes either the elimination of pathological tau aggregates or reducing MAPT expression, and thus the amount of tau protein made to prevent its aggregation. Disease-associated tau affects brain regions in a sequential manner that includes cell-to-cell spreading.

Paradoxical Impacts of Social Relationship on Well-Being During the COVID-19 Pandemic.

Social interaction is an important source of psychological and physical well-being during normal times. However, following the COVID-19 outbreak, which spreads rapidly from person to person, social interaction poses a fatal threat to one's health and life. Therefore, several countries including South Korea implemented an intense social distancing mandate to prevent the spread of the virus.

Cell-Specific Dysregulation of Iron and Oxygen Homeostasis as a Novel Pathophysiology in PSP.

Objective: Progressive supranuclear palsy (PSP) is a 4R-tauopathy showing heterogeneous tau cytopathology commencing in the globus pallidus (GP) and the substantia nigra (SN), regions also associated with age-related iron accumulation. Abnormal iron levels have been extensively associated with tau pathology in neurodegenerative brains, however, its role in PSP pathogenesis remains yet unknown. We perform the first cell type-specific evaluation of PSP iron homeostasis and the closely related oxygen homeostasis, in relation to tau pathology in human postmortem PSP brains.

Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease.

In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause remains unclear. Here, we used the Collaborative Cross (CC) forward genetics mouse platform to identify modifier genes of neuronal hyperexcitation. We found LAMP5 as a novel regulator of hyperexcitation in mice, critical for the survival of distinct interneuron populations.

Development of Core Educational Content for Heart Failure Patients in Transition from Hospital to Home Care: A Delphi Study.

Heart failure (HF) patients should be systematically educated before discharge on how to manage with standard written materials for patient self-management. However, because of the absence of readily available written materials to reinforce their learned knowledge, patients with HF feel inadequately informed in terms of the discharge information provided to them. This study aimed to develop core content to prepare patients with HF for transition from hospital to home care.

How Can We Increase Pro-environmental Behavior During COVID-19 Pandemic? Focusing on the Altruistic (vs. Egoistic) Concerns.

Would the life-threatening pandemic impact pro-environmental behavior? This study demonstrates the effects of coronavirus disease 2019 (COVID-19) on pro-environmental product consumption. Two experimental studies manipulated individuals' COVID-19 concerns and the presence/absence of pro-environmental prompts. In study 1, we found that consumers indicated lower purchase intention for a product with the environmental prompts when recalling COVID-19 concerns compared to normal situations.

Simultaneous Effects of Carboxyl Group-Containing Hyperbranched Polymers on Glass Fiber-Reinforced Polyamide 6/Hollow Glass Microsphere Syntactic Foams.

The hollow glass microsphere (HGM) containing polymer materials, which are named as syntactic foams, have been applied as lightweight materials in various fields. In this study, carboxyl group-containing hyperbranched polymer (HBP) was added to a glass fiber (GF)-reinforced syntactic foam (RSF) composite for the simultaneous enhancement of mechanical and rheological properties. HBP was mixed in various concentrations (0.

Protracted course progressive supranuclear palsy.

Background And Purpose: Progressive supranuclear palsy (PSP) encompasses a broader range of disease courses than previously appreciated. The most frequent clinical presentations of PSP are Richardson syndrome (RS) and PSP with a predominant Parkinsonism phenotype (PSP-P). Time to reach gait dependence and cognitive impairment have been proposed as prognostic disease milestones.