Publications by authors named "Samarthkumar Thakkar"

Adjunctive thrombectomy during percutaneous coronary intervention (PCI) involves the mechanical removal of thrombus prior to balloon inflation and stent deployment .This has been a topic of ongoing debate in the management of ST-elevation myocardial infarction (STEMI), with prior studies yielding mixed outcomes. In this retrospective cohort study utilizing the TriNetX network, we analyzed data from hospitalized STEMI patients who underwent PCI between January 1, 2016, and December 31, 2023, stratifying them based on the use of adjunctive thrombectomy.

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Introduction: Advances in cardiac implanted electronic devices (CIED) have significantly improved outcomes for patients with heart failure. However, there is a bereft of recent real- world data on the relative effectiveness of cardiac resynchronization therapy with pacing and defibrillator (CRT-D) and continuous resynchronization therapy with pacing (CRT-P) in patients with nonischemic cardiomyopathy (NICM). We hypothesized that the addition of defibrillation therapy in patients with NICM would offer no significant benefit.

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Purpose Of Review: This review explores the epidemiology, clinical traits, and diagnosis of Transcatheter Aortic Valve Replacement-Associated Infective Endocarditis (TAVR-IE) and mitral transcatheter edge-to-edge repair infective endocarditis (TEER-IE), focusing on a multimodal imaging approach. It addresses the rising prevalence of TAVR and TEER, emphasizing the need to understand long-term complications and clinical consequences, which poses significant challenges despite advancements in valve technology.

Recent Findings: Studies report a variable incidence of TAVR-IE and TEER-IE influenced by diverse patient risk profiles and procedural factors.

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Article Synopsis
  • - McLeod's syndrome (MLS) is an X-linked genetic disorder linked to the XK gene that results in neurological issues and heart problems, specifically cardiomyopathy.
  • - The case discussed involves a 44-year-old White male experiencing a severe heart failure flare-up due to MLS.
  • - Treatment included following standard medical guidelines and using an implantable cardioverter defibrillator, leading to improvement in his heart's ejection fraction.
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Background: High-grade or complete atrioventricular block (AVB) requiring permanent pacemaker (PPM) implantation is a known complication of transcatheter aortic valve replacement (TAVR). Wenckebach AVB induced by rapid atrial pacing (RAP) after TAVR was previously demonstrated in an observational analysis to be an independent predictor for PPM. We sought to investigate the utility of both pre- and post-TAVR RAP in predicting PPM implantation.

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The management of concomitant mitral valve (MV) disease in patients with hypertrophic cardiomyopathy (HCM) remains controversial. The 2020 American Heart Association/American College of Cardiology HCM guidelines recommend that MV replacement (MVR) at the time of myectomy should not be performed for the sole purpose of relieving outflow obstruction. At the national level, limited data exist on the surgical outcomes of MV repair/replacement in patients with HCM who underwent septal myectomy (SM).

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There is a paucity of data about the sex differences in acute coronary syndrome (ACS) outcomes in patients with prior mediastinal radiation. The National Inpatient Sample database from years 2009 to 2020 were queried for ACS hospitalizations of patients with prior mediastinal radiation. The primary outcome was MACCE (major cardiovascular events), and secondary outcomes included other clinical outcomes.

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Objective: To assess the effect of atrial fibrillation (AF) on outcomes in hospitalizations for non-traumatic intracerebral hemorrhage (ICH).

Patients And Methods: We queried the National Inpatient Sample database between January 1, 2016, and December 31, 2019, to identify hospitalizations with an index diagnosis of non-traumatic ICH using ICD-10 code I61. The cohort was divided into patients with and without AF.

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Background: Influenza disproportionately affects individuals with underlying comorbidities. Long-term follow-up studies have shown that patients with cancer with influenza have higher mortality. However, very little is known about the in-hospital mortality and cardiovascular outcomes of influenza infection in cancer hospitalisations.

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Background: Influenza disproportionately affects individuals with underlying comorbidities. Long-term follow-up studies have shown that patients with cancer with influenza have higher mortality. However, very little is known about the in-hospital mortality and cardiovascular outcomes of influenza infection in cancer hospitalisations.

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A 62-year-old male presented to the emergency department with acute viral bronchitis and worsening of his chronic dyspnea on exertion. Incidentally, a murmur was detected on physical examination. Extensive work-up, including coronary computed tomography angiography, revealed a rare combination and potential association between severe bicuspid aortic valve stenosis and coronary-pulmonary artery fistulas.

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Background: The use of cannabis has massively increased among younger patients due to increasing legalization and availability.

Methods: We performed a retrospective nationwide study using the Nationwide inpatient sample (NIS) database to analyze the trends of acute myocardial infarction (AMI) in young cannabis users and related outcomes among patients aged 18-49 years from 2007 to 2018, using ICD-9 and ICD-10 codes.

Results: Out of 819,175 hospitalizations, 230,497 (28%) admissions reported using cannabis.

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Background: Atrial fibrillation (AF) is relatively less frequent in younger patients (age < 50). Recently, studies have suggested that early restoration of sinus rhythm may lead to improved outcomes compared with rate control, however the efficacy of catheter ablation for AF in young is scarce.

Methods: We included all hospitalized patients between 18 and 50 years with a diagnosis of AF from the Nationwide Readmission Database 2016-2017 from the Healthcare Cost and Utilization Project.

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Article Synopsis
  • Research on endovascular treatment (EVT) for acute limb ischemia (ALI) in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) is limited.
  • A study analyzed hospitalizations from 2015 to 2017, revealing that patients with advanced CKD (stages III-V) faced significantly higher in-hospital mortality and complications compared to those without CKD.
  • The findings highlight that patients with severe CKD and ESRD have worse health outcomes and increased healthcare costs after EVT for ALI, indicating the need for better treatment guidelines for these patients.
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  • The prevalence of hospitalizations for ventricular tachycardia (VT) in young adults under 45 years is increasing, with significant rises in all-cause mortality rates and cardiac arrest incidents over different four-year periods from 2005 to 2018.
  • Data was analyzed from over 5 million hospitalizations, revealing a concerning trend in both the number of young adults admitted with VT and associated economic burdens, such as increased hospital costs.
  • The study found that while the average age of those hospitalized remained relatively stable, the demographic consistently showed a higher percentage of males and White individuals, highlighting potential disparities in risk factors related to race and gender.
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Article Synopsis
  • The study compared outcomes of patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) and complex coronary disease who underwent either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG).
  • No significant differences in major cardiac adverse events (MACE) or survival rates were found between PCI and CABG after 30 days.
  • However, during long-term follow-up, PCI was linked to a higher risk of MACE compared to CABG, although both procedures had similar rates of stroke and all-cause mortality.
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Background There is a paucity of data on the feasibility of same-day discharge (SDD) following transcatheter aortic valve implantation (TAVI) at a national level. Methods and Results This study used data from the Nationwide Readmission Database from the fourth quarter of 2015 through 2019 and identified patients undergoing TAVI using the claim code 02RF3. A total of 158 591 weighted hospitalizations for TAVI were included in the analysis.

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Current guidelines recommend 6-12 months of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) followed by aspirin monotherapy indefinitely. We aimed to assess the efficacy and safety of clopidogrel vs aspirin in the post-PCI population after completing DAPT. We systematically searched 5 electronic databases to identify studies comparing clopidogrel with aspirin following completion of DAPT after PCI.

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Major bleeding has been identified as one of the most common complications after transcatheter aortic valve implantation (TAVI) with some suffering gastrointestinal bleeding (GIB). This study aimed at assessing the incidence and predictors of GIB after TAVI in the United States. We performed a retrospective analysis of data from the National Inpatient Sample database from 2011 to 2018.

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Background: The level of representation of women in cardiology remains low compared to that of men, particularly in leadership positions. We evaluated gender disparity in the authorship of Canadian Cardiovascular Society (CCS) guidelines.

Methods: All CCS guidelines from 2001-2020 were identified.

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Contemporary data on gender differences in outcomes after transcatheter aortic valve implantation (TAVI), after stratification by age, remain limited. We studied age-stratified (60 to 70, 71 to 80, and 81 to 90 years) inhospital outcomes by gender after TAVI from the National Inpatient Sample database between 2012 and 2018. We analyzed National Inpatient Sample data using the International Classification of Diseases, Clinical Modification, Ninth Revision, and Tenth Revision claims codes.

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