Publications by authors named "Adnan Kharsa"
Background: Familial hypercholesterolemia (FH) is a genetic condition characterized by high levels of low-density lipoprotein (LDL) and early atherosclerotic cardiovascular disease.
Case Summary: Our patient was a 61-year-old woman who had been referred to a cardiologist for LDL levels >200 mg/dL for more than a decade. She tested positive for a pathogenic LDLR mutation and was diagnosed with FH.
Effect of sodium glucose cotransporter 2 inhibitors on atrial tachy-arrhythmia burden in patients with cardiac implantable electronic devices.
J Cardiovasc Electrophysiol
August 2023
Article Synopsis
- - The study investigates the impact of sodium glucose cotransporter 2 inhibitors (SGLT2i) on atrial tachyarrhythmias (ATA) in patients with cardiac implantable electronic devices (CIEDs), revealing a notable reduction in ATA hospitalizations linked to SGLT2i use.
- - Analyzing data from 13,888 patients over 24,442 years of follow-up, results show a 22% decrease in ATA risk and all-cause mortality among SGLT2i users, particularly in heart failure patients, but no significant effect on ventricular tachyarrhythmias (VTA).
- - The findings suggest that SGLT2i can significantly lower ATA and mortality
Biological Life-Stage and the Burden of Cardiac Events in Women With Congenital Long QT Syndrome.
Circ Arrhythm Electrophysiol
December 2022
Article Synopsis
- The study compared outcomes of patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) and complex coronary disease who underwent either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG).
- No significant differences in major cardiac adverse events (MACE) or survival rates were found between PCI and CABG after 30 days.
- However, during long-term follow-up, PCI was linked to a higher risk of MACE compared to CABG, although both procedures had similar rates of stroke and all-cause mortality.
Article Synopsis
- A 51-year-old man with a history of diffuse lymphadenopathy presented with chest pain and a rash on his lower legs.
- After undergoing various diagnostic tests including imaging, lab tests, and biopsy, he was diagnosed with rheumatoid vasculitis.
- His condition was notably complicated by an unusual case of constrictive pericarditis.
There are limited data regarding the utility of troponin testing in patients presenting with non-cardiovascular (CV) symptoms as the primary manifestation. The study population comprised 2057 patients who presented to the emergency department (ED) of a US healthcare system with non-CV symptoms as the primary manifestation between January and September 2018. We compared the effect of high-sensitivity cardiac troponin T (hs-cTnT) (n = 901) after its introduction vs.
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- Recurrent gastrointestinal bleeding (GIB) is a frequent issue for patients who have undergone left ventricular assist device (LVAD) implantation, prompting the need for effective prevention strategies.
- This study conducted a network meta-analysis of 13 observational studies to compare the effectiveness of six different pharmacologic interventions aimed at preventing GIB.
- The findings indicated that thalidomide, omega-3 fatty acids, octreotide, and danazol significantly reduced the risk of recurrent GIB, while ACE inhibitors/ARBs and digoxin showed no notable benefits.
Meta-analysis of Safety and Efficacy of Anticoagulation versus no Anticoagulation in Octogenarians and Nonagenarians with Atrial Fibrillation.
High Blood Press Cardiovasc Prev
May 2021
Introduction: The role of anticoagulation in octogenarians and nonagenarians with atrial fibrillation (AF) is controversial due to the lack of evidence from randomized controlled trials (RCTs), owing to the under representation of these patients in clinical trials.
Aim: In the present meta-analysis we aim at comparing the clinical benefits and risk of anticoagulation (AC) with no AC in octogenarians and nonagenarians.
Methods: We systematically searched MEDLINE/PubMed, EMBASE/Ovid, and Web of Science databases from the inception to October, 2020.
Article Synopsis
- - The study investigates right ventricular failure (RVF) after left ventricular assist device (LVAD) surgery, focusing on measuring changes in right ventricle strains using echocardiography techniques.
- - It analyzed 17 studies, finding that patients experiencing RVF had significantly lower right ventricle global longitudinal strain (RVGLS) and right ventricle free wall strain (RVFWS) compared to those who did not develop RVF.
- - The results suggest that TTE-derived strains could help predict RVF, while different findings were observed with transesophageal echocardiography (TEE).
Background: This meta-analysis aims to evaluate the utility of speckle tracking echocardiography (STE) as a tool to evaluate for cardiac sarcoidosis (CS) early in its course. Electrocardiography and echocardiography have limited sensitivity in this role, while advanced imaging modalities such as cardiac magnetic resonance (CMR) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) are limited by cost and availability.
Methods: We compiled English language articles that reported left ventricular global longitudinal strain (LVGLS) or global circumferential strain (GCS) in patients with confirmed extra-cardiac sarcoidosis versus healthy controls.
Article Synopsis
- The study compares two treatment methods for ST-elevation myocardial infarction (STEMI) patients with multivessel coronary artery disease: percutaneous coronary intervention (PCI) targeting only the culprit lesion versus multivessel PCI.
- Analyzing data from nine randomized controlled trials with a total of 6,930 patients, the findings suggest that while multivessel PCI reduces cardiac mortality, reinfarction, and major adverse cardiovascular events (MACE), it does not show a significant advantage in overall mortality.
- The trial sequential analysis indicates that while there is evidence supporting the benefits of multivessel PCI for certain outcomes like revascularization, the evidence for a benefit in cardiac mortality and reinfarction remains inconclusive.