Familial Hypercholesterolemia: Still an Enigma.

Background: Familial hypercholesterolemia (FH) is a genetic condition characterized by high levels of low-density lipoprotein (LDL) and early atherosclerotic cardiovascular disease.

Case Summary: Our patient was a 61-year-old woman who had been referred to a cardiologist for LDL levels >200 mg/dL for more than a decade. She tested positive for a pathogenic LDLR mutation and was diagnosed with FH.

Trends in obesity-related ischemic heart disease mortality among adults in the United States from 1999 to 2020.

Background: Obesity is a critical risk factor for ischemic heart disease (IHD), affecting 42% of the U.S. population.

Acute Limb Ischemia Interventions.

Acute limb ischemia (ALI) is characterized by a sudden decrease in limb perfusion that threatens the viability of the limb. ALI can result from various causes including arterial embolism, thrombosis, or trauma. The diagnosis is predominantly clinical, guided by the "6 Ps" mnemonic-pain, pallor, pulse deficit, paralysis, paresthesia, and poikilothermia-and confirmed through imaging modalities if needed.

Temporal trends and procedural safety of mitral valve transcatheter edge to edge repair in patients with previous CABG.

Introduction: Mitral Valve Transcatheter Edge-to-Edge Repair (M-TEER) is a minimally invasive procedure for patients with symptomatic mitral regurgitation. Its outcomes in patients with a history of coronary artery bypass grafting (CABG) remain unclear.

Methodology: We analyzed data from the Nationwide Inpatient Sample, using ICD-10-CM codes for M-TEER and CABG.

Outcomes of mitral valve transcatheter edge to edge repair in patients with coronary chronic total occlusion.

Introduction: It remains unknown whether the concomitant coronary chronic total occlusion (CTO) would affect the outcomes of the Mitral valve Trans-catheter Edge to edge-to-edge repair (M-TEER) procedure.

Methodology: Study population was extracted from the Nationwide Inpatient Sample Data using the International Classification of Diseases and clinical modifications/procedure coding system codes for M-TEER and CTO. Primary outcomes were in-hospital all-cause mortality and net cardiac periprocedural complications.