Multiple-Channel Funnel Adapted Sensing Tube (MFAST) for the Simple and Duplex Detection of Parasites.

Leishmaniasis poses a significant global health threat, infecting millions of people annually, particularly in tropical and subtropical regions. Timely and accurate detection of the species is crucial for effective treatment and control of this debilitating disease. This study introduces the multi-channel funnel adapted sensing tube (MFAST) chip, a simple diagnostic tool designed for the rapid detection of .

Sheath-enhanced concentration and on-chip detection of bacteria from an extremely low-concentration level.

Microfluidic-based sheath flow focusing methods have been widely used for efficiently isolating, concentrating, and detecting pathogenic bacteria for various biomedical applications due to their enhanced sensitivity and exceptional integration. However, such a microfluidic device usually needs complicated device fabrication and sample dilution, hampering the efficient and sensitive identification of target bacteria. In this study, we develop and fabricate a sheath-assisted and pneumatic-induced nano-sieve device for achieving the improved on-chip concentration and sensitive detection of (MRSA).

Instrument-Free Point-of-Care Diagnostic for Leishmania Parasites.

Background/objective: Leishmaniasis is the second deadliest parasitic disease in the world, after malaria, with an estimated 1.6 million new cases each year. While cutaneous leishmaniasis can result in permanent scars from lesions after treatment, the mucocutaneous and visceral diseases can result in life-altering and life-threatening complications.

Durable Antimicrobial Microstructure Surface (DAMS) Enabled by 3D-Printing and ZnO Nanoflowers.

Numerous studies have been trying to create nanomaterial-based antimicrobial surfaces to prevent infections due to bacterial growth. One major challenge in real-world applications of these surfaces is their mechanical durability. In this study, we introduce durable antimicrobial microstructure surface (DAMS), which integrates DLP 3D-printed microstructures with zinc oxide (ZnO) nanoflowers.

Durable Antimicrobial Microstructure Surface (DAMS) Enabled by 3D-Printing and ZnO Nanoflowers.

A. Numerous studies have been trying to create nanomaterials based antimicrobial surfaces to combat the growing bacterial infection problems. Mechanical durability has become one of the major challenges to applying those surfaces in real life.

Transitional responses of tree growth to climate warming at the southernmost margin of high latitudinal permafrost distribution.

The marked increase in temperature warming and permafrost degradation has raised apprehensions about the fate of forests of boreal forests in permafrost regions. However, the impact of climate on tree growth is not limited to direct effects but also involves complex interactions with permafrost. The degradation of permafrost poses a threat to forest growth that has received insufficient attention thus far, after analyzing the impact of permafrost degradation and climate on Dahurican larch (Larix gmelinii) growth from six forest sites with two maximum active layer thickness (ALT) classifications (more and less than tree root length) across the southern margin of the permafrost region.

Pneumatic nano-sieve for CRISPR-based detection of drug-resistant bacteria.

The increasing prevalence of antibiotic-resistant bacterial infections, particularly methicillin-resistant (MRSA), presents a significant public health concern. Timely detection of MRSA is crucial to enable prompt medical intervention, limit its spread, and reduce antimicrobial resistance. Here, we introduce a miniaturized nano-sieve device featuring a pneumatically-regulated chamber for highly efficient MRSA purification from human plasma samples.

Pneumatic Nano-Sieve for CRISPR-based Detection of Drug-resistant Bacteria.

The increasing prevalence of antibiotic-resistant bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA), presents a significant public health concern. Timely detection of MRSA is crucial to enable prompt medical intervention, limit its spread, and reduce antimicrobial resistance. Here, we introduce a miniaturized nano-sieve device featuring a pneumatically-regulated chamber for highly efficient MRSA purification from human plasma samples.

Superhydrophobic Rotation-Chip for Computer-Vision Identification of Drug-Resistant Bacteria.

The transport, distribution, and mixing of microfluidics often require additional instruments, such as pumps and valves, which are not feasible when operated in point-of-care (POC) settings. Here, we present a simple microfluidic pathogen detection system known as Rotation-Chip that transfers the reagents between wells by manually rotating two concentric layers without using external instruments. The Rotation-Chip is fabricated by a simple computer numerical control (CNC) machining process and is capable of carrying out 60 multiplexed reactions with a simple 30 or 60° rotation.

Tree growth is connected with distribution and warming-induced degradation of permafrost in southern Siberia.

Hemiboreal and boreal forests growing at the southern margin of the permafrost distribution are vulnerable to climate warming. However, how climate warming threatens the growth of dominant tree species that are distributed on permafrost remains to be determined, particularly in synchrony with warming-induced permafrost degradation. Tree growth in the permafrost region of southern Siberia was hypothesized to be highly sensitive to temperature increasing and warming-induced permafrost degradation.

Analysis of 2,4-epibrassinolide created an enhancement tolerance on Cd toxicity in Solanum nigrum L.

Contamination of soils with cadmium (Cd) is a serious problem worldwide. Solanum nigrum L. is reported as a Cd hyperaccumulator, but its enrichment capacity is limited.