Publications by authors named "Rong-Chen Dai"
Draft Genome of Naganishia uzbekistanensis from a Clinical Pulmonary Infection.
Mycopathologia
January 2025
This study presents the first high-quality assembled genome of Naganishia uzbekistanensis, derived from a clinical isolate CY11558 obtained from a patient with a postoperative pulmonary infection. This work provides an improved reference assembly for downstream research and diagnosis of infections caused by this species.
View Article and Find Full Text PDFComplete Genome Sequence of Candida mucifera from an Otitis Media Patient.
Mycopathologia
September 2024
Article Synopsis
- The study presents the first detailed genome analysis of a rare human yeast pathogen called Candida mucifera, identified in a patient suffering from chronic ear infections.
- Researchers found that this pathogen shows lower effectiveness to azole antifungals, which are commonly used to treat fungal infections.
- The findings suggest that Candida mucifera has similarities in drug resistance to its related species in the Trichomonascus ciferrii complex.
Genome-wide analysis of in vivo-evolved Candida auris reveals multidrug-resistance mechanisms.
Mycopathologia
April 2024
Article Synopsis
- Candida auris is a multidrug-resistant fungal pathogen causing outbreaks in China, and its resistance mechanisms are not fully understood, especially in strains developed in live hosts.
- The study analyzed 16 strains from two patients using whole-genome sequencing, revealing all belonged to the South Asian lineage with distinct mutations linked to antifungal resistance, particularly in the ERG11 and TAC1b genes.
- The findings indicate a potential transmission of C. auris and highlight the need for further research into the genetic mutations and resistance mechanisms to improve monitoring and treatment strategies.
Draft Genome Sequence of Candida saopaulonensis from a Very Premature Infant with Sepsis.
Mycopathologia
April 2024
The rare fungus Candida saopaulonensis has never been reported to be associated with human infection. We report the draft genome sequence of the first clinical isolate of C. saopaulonensis, which was isolated from a very premature infant with sepsis.
View Article and Find Full Text PDFInvasive diseases caused by the globally distributed commensal yeast Candida tropicalis are associated with mortality rates of greater than 50%. Notable increases of azole resistance have been observed in this species, particularly within Asia-Pacific regions. Here, we carried out a genetic population study on 1571 global C.
View Article and Find Full Text PDFEmergence of multiple fluconazole-resistant Candida parapsilosis sensu stricto clones with persistence and transmission in China.
J Antimicrob Chemother
January 2024
Article Synopsis
- This study investigates the characteristics and azole resistance mechanisms of Candida parapsilosis isolates in China.
- Out of 2318 isolates tested, 2.4% were resistant to fluconazole, especially prevalent among ICU patients, highlighting significant genetic clustering and transmission.
- Key mutations were identified, including Erg11Y132F, which contributes to resistance, along with others that play a role in increasing resistance levels and cross-resistance to different azoles.
Candia (Starmera) stellimalicola is a yeast species spread worldwide and recovered from varieties of ecological reservoirs, but human infections are rarely reported. In this study, we reported an intra-abdominal infection case caused by C. stellimalicola and described its microbiological and molecular characteristics.
View Article and Find Full Text PDFA pseudo-outbreak of funguria: Implication from whole genome sequencing assay.
Front Cell Infect Microbiol
March 2023
Background: Although the yeast () has been rarely reported in human infections, nosocomial outbreaks caused by this organism have been documented. Here we report a pseudo-outbreak of in a urology department of a Chinese hospital over a two-week period.
Methods: Three patients were admitted to the urology department of a tertiary teaching hospital in Beijing, China, from Nov to Dec 2018, for different medical intervention demands.
Traditional Chinese medicine treatment for COVID-19: An overview of systematic reviews and meta-analyses.
J Integr Med
September 2022
Background: Coronavirus disease 2019 (COVID-19) is a rapidly spreading disease that has caused an extensive burden to the world. Consequently, a large number of clinical trials have examined the efficacy of traditional Chinese medicine (TCM) for treating and preventing COVID-19, with coinciding proliferation of reviews summarizing these studies.
Objective: This study aimed to evaluate the methodological quality and evidence quality of systematic reviews and meta-analyses on the efficacy of TCM.