Computational identification of membrane proteins for vaccine design against drug-resistant Moraxella catarrhalis.

Moraxella catarrhalis is a Gram-negative diplococcus bacterium and a common respiratory pathogen, implicated in 15-20% of otitis media (OM) cases in children and chronic obstructive pulmonary disease (COPD) in adults. The rise of drug-resistant Moraxella catarrhalis has highlighted the urgent need for the potent vaccine strategies to reduce its clinical burden. Despite a mortality rate of 13%, there is no FDA-approved vaccine for this pathogen.

A comprehensive review on superficial mycoses, classification, conventional/new therapeutic approaches and fungal-drug resistance.

Mycoses (fungal infections) are highly emerging threat to public health globally. Among six million fungal species, less than 1 % is pathogenic and infects peoples. Most of them affecting skin, nail and hair, which are very common diseases known as superficial mycosis.

Correction: Development of a subunit vaccine against the cholangiocarcinoma causing : a computational approach.

[This corrects the article DOI: 10.3389/fimmu.2024.

Genome-wide identification, expression patterns and functional analysis of TALE (Three Amino-Acid Loop Extension) transcription factors in Arabidopsis thaliana.

Background: Members of the TALE gene family play a crucial part as transcription factors, governing flower organs development, organ morphogenesis, flower meristem organization, and the development of fruits. However, detailed genome-wide study and functional analysis of TALE transcription factors has not yet been conducted in the model plant A. thaliana.

Preparation, Characterization and Removal of Acid Blue 129 and Erioglaucine Dyes from Aqueous Solution by Corn Cob Based Activated Carbon.

Herein, corn cobs (maize) have been converted into an activated carbon by subjecting to carbonization which were then treated with 1:1 solution of HCl and HNO and finally passed through CH solution and finally activated at a high temperature of 400◦C. The obtained activated sample was subjected to XRD, EDX, and SEM analysis. The surface area was estimated as 913 m/g using a reported method in literature.

Synthesis of aceclofenac and L-Arginine salt, characterization and bioactivities.

Molecular salt synthesis is promising technique for increasing the bioavailability and solubility of the FDA-drugs. The present investigations focus on the synthesis of aceclofenac salt in a 1:1 molar ratio, employing the rapid solvent evaporation precipitation technique in conjunction with the coformor l-arginine. The salt was characterized through Fourier Transform Infrared (FTIR), Differential Scanning Calorimeter (DSC), Powder X-ray Diffraction (PXRD) and Thermo Gravimetric Analysis (TGA).

Effect of convective drying temperature and tray load density on bioactive compounds, antioxidant properties, and functional quality of radish Sango microgreens.

This study examined the effects of convective drying parameters, including temperature (40, 50, and 60 °C) and tray loading density (0.057 and 0.113 g/cm), on the bioactive compounds, antioxidant properties, and structural characteristics of radish sango microgreens powder.

Corrigendum: Computational analysis of Ayurvedic metabolites for potential treatment of drug-resistant .

[This corrects the article DOI: 10.3389/fcimb.2025.

Computational analysis of Ayurvedic metabolites for potential treatment of drug-resistant .

This study explored the effectiveness of secondary metabolites of referred traditional Ayurvedic plants in treating fungal infections, particularly targeting . Recognized as a global health threat, this fungus is notorious for its resistance to several antifungal treatments. The inhibition of lanosterol 14α-demethylase causes the depletion of ergosterol, ultimately resulting in the inhibition of fungal cell growth.

Characterization of Volatile Compounds and Biological Effects Capacities of Moroccan Thymus capitatus L., Essential Oils: In Vitro and In Silico Approaches.

The present study investigated the phytochemical composition of Thymus capitatus L. essential oil (TCEO) harvested in Morocco using GC-MS-MS analysis. Both in vitro and in silico approaches were combined to investigate the antioxidant, antibacterial, antidiabetic, dermatoprotective, and neuroprotective properties of TCEO as well as to identify the main compounds responsible of the promising properties.

Synthesis, and evaluation of amide derivatives as prospective antimicrobial and antileishmanial agents.

This study focused on the synthesis, antimicrobial, and antileishmanial evaluation of seven amide derivatives ( to ). The target compounds were synthesized from cysteine methyl ester and various substituted aromatic and aliphatic carboxylic acids. The final products were characterized using physical and spectro-analytical techniques (FT-IR, H NMR).

Redox cycling of sulfur via microbes in soil boosts the bioavailability of nutrients to Brassica napus.

Deficiency of sulfur (S) has been recognized for both dry and wetland plants as a significant growth limiting factor. S-oxidizers enhance the oxidation rate of S and increase sulfate (SO4 - 2) production by making them available in critical growth stages, resulting in higher plant growth and yield. A two-phase study was undertaken to assess the effectiveness of microbial redox reactions on soil nutrient bioavailability and crop growth.

Exploring cotton plant compounds for novel treatments against brain-eating Naegleria fowleri: An In-silico approach.

To find potential inhibitors of Naegleria fowleri S-adenosyl-L-homocysteine hydrolase (NfSAHH), a brain-eating parasite, structure-based drug design was adopted. N. fowlerica causes primary amebic meningoencephalitis (PAM), a fatal central nervous system (CNS) disorder if untreated.

Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer.

Platelet-derived growth factor alpha (PDGFRA) plays a significant role in various malignant tumors. PDGFRA expression boosts thyroid cancer cell proliferation and metastasis. Radiorefractory thyroid cancer is poorly differentiated, very aggressive, and resistant to radioiodine therapy.

Trace level detection of Pb ion using organic ligand as fluorescent-on probes in aqueous media.

In this study, an optical sensor, JA/(2,6-di((E)-benzylidene)cyclohexan-1-one), was synthesized and characterized using H NMR and FT-IR spectroscopy. The sensor exhibited high efficiency and selectivity in detecting Pb ions, even in the presence of potential interfering ions such as Mn, Cu, Co, Cr, Ni, Ce, Hg, and Cd in aqueous solutions. The interaction of JA with Pb resulted in a significant enhancement of fluorescence intensity, suggesting the formation of a stable complex.

Integrative physiological, biochemical, and proteomic analysis of the leaves of two cotton genotypes under heat stress.

Cotton (Gossypium hirsutum L.), a crucial global fibre and oil seed crop faces diverse biotic and abiotic stresses. Among these, temperature stress strongly influences its growth, prompting adaptive physiological, biochemical, and molecular changes.

Core-genome guided novel therapeutic targets identification and chimeric vaccine designing against Rickettsia rickettsii.

Rocky Mountain Spotted Fever, caused by the gram-negative intracellular bacteria Rickettsia rickettsii, is a serious tick-borne infection with a fatality rate of 20-30%, if not treated. Since it is the most serious rickettsial disease in North America, modified prevention and treatment strategies are of critical importance. In order to find new therapeutic targets and create multiepitope vaccines, this study integrated subtractive proteomics with reverse vaccinology.

Immunomodulatory properties of Giloy () leaves and its applications in value-added products.

In Ayurvedic texts, Giloy ( have been known as the most potent and important medicinal product. Giloy leaves have been used for centuries to cure various ailments and diseases in the human body. This review highlights that giloy leaves have immunomodulatory properties and can be used to develop functional food products.

Peptide-based vaccine design against Hendra virus through immunoinformatics approach.

The Hendra virus (HeV) has resulted in epidemics of respiratory and neurological illnesses in animals. Humans have contracted diseases with high fatality rates as a result of infected domestic animals, but effective vaccinations and therapies are currently not available against HeV. Herein, we analyzed the proteome of HeV and constructed an effective and innovative multi-epitope vaccine using immunoinformatics techniques.

Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery.

Free radical polymerization technique was used to formulate Poloxamer-188 based hydrogels for controlled delivery. A total of seven formulations were formulated with varying concentrations of polymer, monomer ad cross linker. In order to assess the structural properties of the formulated hydrogels, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), Scanning electron microscopy (SEM), and X-ray diffraction (XRD) were carried out.

Soil health in Moroccan olive agroecosystems: The bioindication role of terrestrial nematode dynamics.

Terrestrial nematodes are important soil microorganisms that modulate biological processes in soil ecosystems. Thus, these microorganisms have strong potential as soil health bioindicators. This study aimed to investigate their distribution patterns in Moroccan olive agroecosystems and to evaluate their structural and functional dynamics shaping soil disturbance status.

Screening Asian Medicinal Plants for SARS-CoV-2 Inhibitors: A Computational Approach.

This work aimed to evaluate the antiviral potential of compounds from Asian medicinal plants against SARS-CoV-2's main protease and spike glycoprotein, identifying dual inhibitors from these plants that target both proteins through advanced virtual screening, molecular dynamics simulations, and pharmacophore analysis. An in-house library of 335 antiviral natural products was prepared from the selected medicinal plants. Following the virtual screening of this library against the main protease and spike glycoprotein, top compounds were subjected to downstream analysis for evaluating druggability potential and toxicity analysis.

Exploring the genomic potential of Kytococcus schroeteri for antibacterial metabolites against multi-drug resistant Mycobacterium tuberculosis.

The versatile bacterium Kytococcus schroeteri is known for producing putative secondary metabolites. These include antimicrobials and other therapeutically significant compounds. The emergence of antibiotic-resistant pathogens has necessitated the exploration of possible sources for novel drug candidates.

Computer-aided rational design of a mRNA vaccine against Guanarito mammarenavirus.

Purpose: Guanarito mammarenavirus (GTOV) is a highly pathogenic virus that leads to Venezuelan hemorrhagic fever (VHF). Despite being a severe disease, there are currently no commercially available drugs or vaccines for its prevention.

Methods: Here we computationally formulated a mRNA vaccine construct (VC) from the genome of GTOV to produce immunity against its infections.

Probiotic significance of strains: a comprehensive review on health impacts, research gaps, and future prospects.

A rising corpus of research has shown the beneficial effects of probiotic on human health, contributing to the growing popularity of these microorganisms in recent decades. The gastrointestinal and urinary tracts are home to these bacteria, which play a vital role in the microbial flora of both humans and animals. The probiotic, i.