Impacts of r-GO and N-doping on the structural, magnetic, optical and photocatalytic properties of CuAlO: enhanced crystal violet removal under solar light irradiation.

Designing a magnetically recyclable and visible-light-driven photocatalyst is of great importance in environmental remediation. Realizing efficient removal of persistent azo dyes from industrial wastewater is still a major challenge for researchers. In this context, herein, novel CuAlO and N/rGO nanohybrids, CA-N/GO(1-4), were synthesized an ultrasonic method and assessed for their efficiency toward the photocatalytic removal of crystal violet (CV) dye from simulated polluted water under visible irradiation.

A novel heuristic Morlet wavelet neural network design for the painlevé equation-II arising in nonlinear optics.

The current investigations present the novel structure of Morlet wavelet neural network (MWNN) for the numerical solutions of Painlevé equation-II arising in nonlinear optics. An error based fitness function is constructed using the sense of differential model and its initial or boundary conditions, which is further optimized through the hybrid computing terminologies of the global search genetic algorithm (GA) and local search interior-point algorithm (IPA), i.e.

Role of pharmacist in adverse drug reaction reporting: Enhancing antifungal safety and pharmacovigilance in cancer patients.

Globally, adverse drug reactions (ADRs) are considered as a serious public health problem. Cancer patients are more prone to ADRs due to altered physiological environment and polypharmacy. This study aimed to assess the role of pharmacists in reporting adverse drug reactions in cancer patients exposed to antifungal therapy in Pakistan.

Prophylactic cardiac denervation to prevent post-operative atrial fibrillation after coronary artery bypass grafting: a systematic review and meta-analysis.

Background: Despite revolutionary advances in the field of percutaneous coronary intervention (PCI), a significant number of patients with coronary artery disease (CAD) require coronary artery bypass grafting (CABG), which is associated with postoperative atrial fibrillation (POAF) risk. This meta-analysis evaluates the efficacy and safety of prophylactic cardiac denervation (PCD) during CABG to prevent POAF.

Methods: A systematic search was conducted across PubMed, CENTRAL, Web of Science, Scopus, and Embase until December 2024.

Unique Dermatological and Systemic Manifestations in a Classic Pediatric Case of Kindler Syndrome: A Case Report and Literature Review.

Kindler Syndrome (KS) is a rare, autosomal recessive genodermatosis caused by mutations in the FERMT1 gene, leading to skin fragility, blistering, photosensitivity, and progressive poikiloderma. We present a unique case of KS in a 6-year-old boy born to consanguineous parents, exhibiting uncommon dermatological, and systemic features. The patient developed multiple erythematous plaques, hemorrhagic crusting, and purulent discharge after birth, with a family history suggesting genetic predisposition.

An automated deep learning framework for brain tumor classification using MRI imagery.

The precise and timely diagnosis of brain tumors is essential for accelerating patient recovery and preserving lives. Brain tumors exhibit a variety of sizes, shapes, and visual characteristics, requiring individualized treatment strategies for each patient. Radiologists require considerable proficiency to manually detect brain malignancies.

Readmission Trends and Outcomes of Transcatheter Edge-to-Edge Repair of Mitral Regurgitation With and Without Atrial Fibrillation: A Propensity-Matched National Readmission Analysis.

Background: The use of transcatheter edge-to-edge repair (TEER) for symptomatic mitral regurgitation is steadily increasing. However, the outcomes of TEER among patients with atrial fibrillation (AF), including readmission trends, remain unknown.

Methods: The Nationwide Readmissions Database was queried between 2016 to 2020 to identify TEER patients with and without AF.

Phenobarbital versus valproate for generalized convulsive status epilepticus in adults. An updated systematic review and meta-analysis.

Background And Objectives: Status epilepticus (SE) is a neurological emergency with significant mortality and morbidity with generalized convulsive SE (GCSE) being the most prevalent. A meta-analysis reported an overall mortality rate of 15.9 % in adults and 3.

Impact of biodegradation on the mechanical and fatigue properties of 3D-printed PLA bone scaffolds.

A proper degradation rate of bone scaffolds ensures optimal mechanical support and effective tissue regeneration. The present study examines the degradation effects of simulated body fluids (SBF) on the compressive and fatigue strength of 3D-printed PLA bone scaffolds. Scaffolds with varying surface-to-volume (S/V) ratios and identical porosity (60 %) were immersed in Hanks' solution for a maximum period of 30 days.

Modified Robust Proportional Overlapping Score for feature selection in high-dimensional micro-array data.

High-dimensional microarray datasets often contain tens of thousands of genes but only a small number of samples, typically ranging from tens to a few hundred. This imbalance, known as the curse of dimensionality or the n ≪ p problem, hampers the learning process. To address this issue, this study introduces the Modified Robust Proportional Overlapping Score (MRPOS), an enhanced feature selection method based on robust measures of dispersion, specifically the Sn and Qn statistics by Rousseeuw and Croux.

Antifungal Resistance Among Candida Species: Diagnostic and Clinical Challenges in Specialized Cancer Care Hospital of Lahore.

Background: The increased consumption of antifungal agents increases the emergence of resistant fungal strains among immunocompromised patients. The present study aims to determine the antifungal consumption and resistance pattern among adult and pediatric cancer patients with systemic Candida infections.

Method: A descriptive, retrospective study was conducted by reviewing admitted patients' electronic medical records from 2019 to 2023.

Population pharmacokinetic analysis of intravenous voriconazole in cancer patients.

Purpose: The pharmacokinetics of voriconazole have been studied across various populations but data specific to the Pakistani cancer population has not yet been reported. The aim of present study was to explore and identify covariates that affect pharmacokinetics of intravenous voriconazole in Pakistani cancer population.

Methods: The therapeutic drug monitoring data from January1st, 2023 to December 31st, 2023 of cancer patients receiving intravenous voriconazole for systemic fungal infections were taken from electronic medical record of the hospital.

Deciphering Host-Pathogen Interactions: Role of in Tumorigenesis.

, a protozoan parasite affecting the gastrointestinal system, is primarily known for causing diarrhea, especially in those with weakened immune systems. However, there is increasingly persuasive evidence that it may be directly involved in tumorigenesis. This review examines some of the potential mechanisms through which infections can induce cancer, specifically chronic inflammation, manipulation of the immune system, and alteration of cell signaling pathways.

Therapeutic potential of Solanum surattense against hepatitis C virus in liver hepatoma cells.

Hepatitis C virus (HCV) causes chronic liver disease (CLD) and severe morbidity and mortality worldwide. For chronically infected HCV patients, direct-acting antivirals (DAAs) are the standard therapy. HCV treatment is still hindered by drug resistance due to resistance-associated substitutions (RASs).

The Spectrum of Diagnostic Findings in Postcardiotomy Tamponade.

• Localized tamponade can be seen following cardiac surgery. • Localized right atrial tamponade can cause functional TS. • Localized fluid collection fully compressing the RA can mimic the chamber itself.

Antifungal-drug interactions in oncology: A cross-sectional study highlighting the role of pharmacists.

Study Objective: Complex pharmacotherapy in cancer patients increases the likelihood of drug-drug interactions (DDIs). Pharmacists play a critical role in the identification and management of DDIs. The aim of present study was to evaluate the role of pharmacist in identifying antifungal drug interactions in cancer patients and providing relevant recommendations.

Development and nutritional evaluation of pomegranate peel enriched bars.

Pomegranate peel powder is used as a functional ingredient in the development of nutritional bars. Pomegranate (Punica granatum) is well known fruit belongs to punicaceae family having multiple health benefits, not only limited to its edible parts but also in its non-edible parts mostly the peel. Fruit wastes are rich source of nutrients, and can be used for the development of functional food products.

6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague-Dawley rats.

Background: Cancer remains a predominant cause of death worldwide. The advent of effective chemotherapy has enormously decreased the mortality rate and increased the life expectancy of cancer patients. However, the adverse effects allied with chemotherapy contribute to the development of neurotoxicity, anxiety, and depression.

Development of Timolol Maleate-Loaded Poloxamer-co-Poly (acrylic acid) based hydrogel for controlled drug delivery.

Free radical polymerization technique was used to formulate Poloxamer-188 based hydrogels for controlled delivery. A total of seven formulations were formulated with varying concentrations of polymer, monomer ad cross linker. In order to assess the structural properties of the formulated hydrogels, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), Scanning electron microscopy (SEM), and X-ray diffraction (XRD) were carried out.

Optimizing antifungal therapy: a systematic review of pharmacist interventions, stewardship approaches, and outcomes.

Introduction: Specific evidence regarding the pharmacist's role in antifungal stewardship (AFS) is emerging. This review aims to identify pharmacist-driven AFS interventions to optimize antifungal therapy.

Methods: A systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Enhanced anticancer and biological activities of environmentally friendly Ni/Cu-ZnO solid solution nanoparticles.

The study investigates the impact of incorporating Ni and Cu into the lattice of ZnO nanoparticles (NPs) to enhance their anticancer and antioxidant properties. Characterization techniques including pXRD, FTIR, UV-visible absorption spectroscopy, FESEM, and EDAX confirm the successful synthesis and structural modifications of Ni/Cu-ZnO NPs. Anticancer activity against breast cancer (MDA) and normal skin (BHK-21) cells reveals dose-dependent cytotoxicity, with Ni/Cu-ZnO NPs exhibiting higher efficacy against MDA cells while being less harmful to BHK-21 cells.

Enhanced forecasting of rice price and production in Malaysia using novel multivariate fuzzy time series models.

A significant portion of the world's population relies on rice as a primary source of nutrition. In Malaysia, rice production began in the early 1960s, which led to the cultivation of the country's most significant food crop up till the present day. Research on various aspects of the price and production of rice has been done by various methods in the past.

Sodium alginate based fast swelling nanogels for solubility enhancement of chlorthalidone; synthesis, characterization and biosafety evaluation.

Purpose of the study was to enhance the solubility of chlorthalidone, poorly soluble diuretic that has been the used for lowering high blood pressure for the past half-century. Solubility is a challenge for approximately 90% of drug candidates. Chlorthalidone is BCS Class IV drug whose poor solubility needs to be improved in order to optimize its efficacy.

Intelligent Wireless Charging Path Optimization for Critical Nodes in Internet of Things-Integrated Renewable Sensor Networks.

Wireless sensor networks (WSNs) play a crucial role in the Internet of Things (IoT) for ubiquitous data acquisition and tracking. However, the limited battery life of sensor nodes poses significant challenges to the long-term scalability and sustainability of these networks. Wireless power transfer technology offers a promising solution by enabling the recharging of energy-depleted nodes through a wireless portable charging device (WPCD).