Lactate dehydrogenase A: a potential new target for tumor drug resistance intervention.

Tumor drug resistance is a crucial scientific and technological issue that urgently needs to be addressed in cancer treatment. In recent years, research on Lactate dehydrogenase A (LDHA) in the field of tumor drug resistance has progressively deepened, with breakthrough advancements achieved. Due to their metabolic characteristics, tumors often exhibit abnormal LDHA expression, which meets their growth requirements by promoting glycolysis and lactate production.

Dual-specific phosphatases-8: a new target for clinical disease intervention.

Dual-specific phosphatase-8 (DUSP8), identified as the first gene in a genome-wide association study (GWAS), is implicated in cellular oxidative stress, proliferation, apoptosis, and drug resistance through its negative regulation of the dephosphorylation activities of JNK, ERK, and p38 within the MAPK pathway. Recent studies have shown that DUSP8 plays a pivotal role in the progression of several human diseases, notably colorectal cancer, diabetic kidney disease, and breast cancer. This suggests that DUSP8 may represent a novel target for clinical intervention in these diseases.

Mitochondria: a new intervention target for tumor invasion and metastasis.

Mitochondria, responsible for cellular energy synthesis and signal transduction, intricately regulate diverse metabolic processes, mediating fundamental biological phenomena such as cell growth, aging, and apoptosis. Tumor invasion and metastasis, key characteristics of malignancies, significantly impact patient prognosis. Tumor cells frequently exhibit metabolic abnormalities in mitochondria, including alterations in metabolic dynamics and changes in the expression of relevant metabolic genes and associated signal transduction pathways.

Mitochondrial respiratory chain component NDUFA4: a promising therapeutic target for gastrointestinal cancer.

Gastrointestinal cancer, one of the most common cancers, continues to be a major cause of mortality and morbidity globally. Accumulating evidence has shown that alterations in mitochondrial energy metabolism are involved in developing various clinical diseases. NADH dehydrogenase 1 alpha subcomplex 4 (NDUFA4), encoded by the NDUFA4 gene located on human chromosome 7p21.