The efficacy of endoscopic submucosal dissection for 10-20 mm rectal neuroendocrine tumors based on resection margin status.

Background: Current guidelines recommend that rectal neuroendocrine tumors (NETs) smaller than 10 mm can be treated by endoscopic resection, whereas tumors larger than 20 mm should be treated by surgical resection. However, the optimal treatment of 10-20 mm rectal NETs remains controversial. We aimed to evaluate the efficacy of endoscopic submucosal dissection (ESD) for 10-20 mm rectal NETs based on resection margin status.

Validation of a clinical scoring model and proposal of a classification system to guide endoscopic resection strategies for cardial submucosal tumors.

Background And Aims: A scoring model was proposed to support endoscopic decision-making for cardial submucosal tumors (SMTs). The aim of this study is to perform a multicenter validation of the clinical scoring model and to introduce a new clinical classification system for cardial SMTs.

Methods: A multicenter analysis of endoscopic decision-making for cardial submucosal tumors (SMTs) was conducted.

Predictors for Achieving Textbook Outcomes After Endoscopic Resection of Giant Submucosal Tumors in the Esophagus and Cardia.

Background And Aims: Endoscopic resection for submucosal tumors (SMTs) in the esophagus and cardia is challenging with hazards of adverse events and the exploration of its achieving textbook outcome (TO) was unknown. We aim to investigate the predictors of TO for giant SMTs with a long diameter ≥ 7 cm or a transverse diameter ≥ 3.5 cm.

Feasibility and safety of endoscopic resection for duodenal gastrointestinal stromal tumors.

Background And Study Aims: Endoscopic resection for duodenal gastrointestinal stromal tumors (GISTs) is still considered a great challenge with a high risk of complications. This study aimed to evaluate effectiveness and safety of endoscopic resection for duodenal GIST.

Patients And Methods: Between June 2013 and August 2024, we performed a retrospective study of patients with duodenal GISTs who underwent endoscopic resection at Zhongshan Hospital.

Endoscopic management of esophagomediastinal fistula following peroral endoscopic myotomy.

Objectives: Esophagomediastinal fistula (EMF) is a rare but important major adverse event (mAE) after peroral endoscopic myotomy (POEM), which is scarcely reported. This study aimed to offer a comprehensive analysis of the evaluation and management of EMF following POEM.

Method: From June 2015 to December 2023, we retrospectively reviewed patients with achalasia receiving POEM.

Feasibility and safety of endoscopic submucosal dissection for the anal canal lesions.

Background And Aims: We aimed to evaluate the technical safety, efficacy, and feasibility of endoscopic submucosal dissection (ESD) for anal canal lesions (ACLs) and compare outcomes between lesions involving the dentate line (IDL) and those above the dentate line (ADL) to guide clinical decision-making.

Methods: We retrospectively investigated 102 patients with ACLs who underwent ESD from August 2010 to August 2023. We collected and analyzed clinicopathologic characteristics, procedure-related parameters, outcomes, and follow-up data.

Expert-AI Collaborative Training for Novice Endoscopists: A Path to Enhanced Efficiency.

Background: Esophagogastroduodenoscopy (EGD) is essential for diagnosing upper gastrointestinal disorders. Traditional training for novice endoscopists is often inefficient and inconsistent. This study evaluates the effectiveness of an AI-assisted system (EndoAdd) in improving EGD training.

Association of Increased Epstein-Barr Virus Reactivation With Imbalanced Immunity and Myenteric Neuron Loss in Achalasia.

Background And Aim: Viral infection has been postulated as a potential etiology of achalasia, yet the definitive role of viral involvement remains elusive. This study aims to elucidate virus infections and to analyze their relationships with clinical characteristics, immunological alterations, and neuron loss.

Methods: We investigated viral infections in achalasia patients (n = 288) and controls (n = 71).

Management of Tunnel Infection Following Upper Gastrointestinal Endoscopic Submucosal Tunneling Procedures.

Objectives: Tunnel infection is a rare but major adverse event after endoscopic submucosal tunneling procedures (ESTPs), which is scarcely reported. This study aims to offer a comprehensive analysis of the evaluation and management of tunnel infection following ESTP.

Method: From August 2010 to December 2023, we retrospectively analyzed 4398 patients with achalasia receiving peroral endoscopic myotomy (POEM) and 2214 patients with upper gastrointestinal tumors receiving submucosal tunneling endoscopic resection (STER).

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing.

Background: Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival. To address this clinical need, we developed GutSeer, a blood-based assay combining DNA methylation and fragmentomics for multi-GI cancer detection.

Peroral endoscopic myotomy for symptomatic blown-out myotomy following previous myotomy for achalasia.

Blown-out myotomy (BOM) may impair the discharge of esophageal contents, leading to recurrent symptoms following myotomy. This study aimed to evaluate the safety and effectiveness of salvage peroral endoscopic myotomy (POEM) for symptomatic BOM.Between August 2011 and August 2022, 77 patients with recurrent achalasia with BOM and 168 with recurrent achalasia without BOM underwent POEM and were retrospectively enrolled.

Scoring system supporting suture decision-making for duodenal submucosal tumors.

Background: In recent years, endoscopic resection (ER) has been employed for the excision of submucosal tumors (SMTs). Nonetheless, ER in the duodenum is linked to elevated risks of both immediate and delayed hemorrhagic complications and perforations. Satisfactory suturing is crucial for reducing the occurrence of complications.

A retrospective study on endoscopic submucosal dissection for the treatment of ileocecal valve lesions.

Background: Endoscopic submucosal dissection (ESD) for ileocecal valve (ICV) lesions poses unique technical challenges because of its anatomic complexity. This study aimed to evaluate the effectiveness and safety of ESD for ICV lesions.

Methods: From December 2016 to June 2023, the clinic characteristics and outcomes of ESD on 51 ICV lesions and 84 cecal lesions were reviewed.

Unsedated emergent ERCP is feasible and efficient for acute cholangitis in old patients over 80 years.

Background: Acute cholangitis in elderly patients poses unique challenges due to comorbidities and frailty, necessitating timely intervention. This study evaluates the feasibility and efficiency of unsedated emergent endoscopic retrograde cholangiopancreatography (ERCP) in patients over 80 years with acute cholangitis.

Methods: A retrospective analysis of elderly patients (≥ 80 years) presenting with acute cholangitis who underwent unsedated emergent ERCP between January 2020 and December 2023 was conducted.

Eye-tracking dataset of endoscopist-AI teaming during colonoscopy: Retrospective and real-time acquisition.

Recent studies have demonstrated that integrating AI into colonoscopy procedures significantly improves the adenoma detection rate (ADR) and reduces the adenoma miss rate (AMR). However, few studies address the critical issue of endoscopist-AI collaboration in real-world settings. Eye-tracking data collection is considered a promising approach to uncovering how endoscopists and AI interact and influence each other during colonoscopy procedures.

Endoscopic retrograde appendicitis therapy for management of chronic fecalith appendicitis.

Background And Aims: Chronic appendicitis is a condition with chronic abdominal pain or mild attacks of appendicitis, seriously affecting the patient's quality of life. Endoscopic retrograde appendicitis therapy (ERAT) has emerged as a promising, non-invasive treatment for acute uncomplicated appendicitis. Here, we aim to assess the safety and efficacy of ERAT for chronic fecalith appendicitis.

Repeat peroral endoscopic myotomy: technical difficulty and risk factors.

Background And Aims: Repeat peroral endoscopic myotomy (Re-POEM) appears to be a promising salvage option for patients with persistent or recurrent symptoms after initial POEM, but it may be more technically challenging. Here we aim to evaluate the safety and technical difficulty of Re-POEM.

Methods: Between July 2012 and October 2023, 158 achalasia patients underwent Re-POEM and were retrospectively enrolled.