The mediating effect of social adaptation and the moderating effect of prosocial behavior on the relationship between physical activity and psychological capital.

This study aims to explore the relationship between physical activity, social adaptation, pro-social behavior, and psychological capital, and to examine the mediating role of social adaptation in the influence of physical activity on psychological capital and the moderating role of pro-social behavior on this mediating effect. In this study, a cross-sectional study design was used to conduct a questionnaire survey on 415 students from a 211 university in Ningxia, and their physical activity, psychological capital, social adaptation and prosocial data were collected during the break. In addition, this study conducted Harman single factor test, independent sample t test, descriptive statistics, correlation analysis, and moderated mediating effect model analysis on the data.

Validation of a Novel Coronary Angiography-Derived Quantitative Functional Assessment Compared with Wire-Based FFR and IMR: The Prospective Multicenter FAIR Study.

Synchronous computation of coronary angiography-derived fractional flow reserve (CAG-FFR) and coronary angiography-derived index of microcirculatory resistance (CAG-IMR) is a novel coronary angiography-based method for on-site assessment of suspected myocardial ischemia in patients with coronary artery disease (CAD). This trial is a prospective, multicenter, controlled study designed to assess the diagnostic performance of CAG-FFR and CAG-IMR in patients with suspected myocardial ischemia using wire-based FFR and IMR as reference standards. The functional parameters were calculated using a reduced order computational fluid dynamics solver that incorporates thrombolysis in myocardial infarction (TIMI) frame count and aortic pressure recorded by a disposable invasive pressure sensor.

Conversion therapy with sintilimab combined with chemotherapy and apatinib in stage IV gastric cancer.

In selected patients with stage IV gastric cancer, radical surgery after conversion therapy may increase survival benefit; however, there is currently no standard protocol for conversion therapy. We explored the feasibility and efficacy of sintilimab plus two-drug chemotherapy (S-1 plus nab-paclitaxel) and apatinib as conversion therapy in patients with stage IV gastric cancer in China. This was a prospective, single-arm, single-center, phase 2 study.

Modeling and simulation of steam-enhanced extraction: Parameter effect of injected steam-air mixture on NAPL remediation at contaminated sites.

Steam enhanced extraction (SEE) shows great potential for the remediation of sites contaminated by non-aqueous phase liquids (NAPLs). The condensation of the injected steam, which is induced by subsurface temperature gradients, is recognized as crucial in hindering the remediation of NAPLs. To quantitatively examine the complex process for an optimal design, this study formulates a thermo-hydro-concentration-moisture coupled two-phase flow model.

Three cytochrome P450 88A subfamily enzymes, CYP88A108, CYP88A164, and CYP88A222, act as β-amyrin 11-oxidases involved in triterpenoid biosynthesis in Melia azedarach L.

Melia azedarach L. serves as an important source of timber and bioactive triterpenoids, notably tetracyclic limonoids and pharmacologically active pentacyclic triterpenes such as β-amyrin derivatives. Although limonoid biosynthesis has been extensively characterized, the enzymatic machinery governing pentacyclic triterpene formation remains poorly defined.

Identification of esophageal cancer tumor antigens and immune subtypes for guiding vaccine development.

Background: Esophageal cancer (ESCA) is a highly aggressive malignancy characterized by poor prognosis, primarily due to late diagnosis and limited treatment efficacy. Immunotherapies, such as vaccines, necessitate a more comprehensive understanding of the tumor immune microenvironment and tumor-specific antigens. The immune heterogeneity of ESCA, which is shaped by immune cell infiltration and antigen presentation, remains largely unexplored, particularly in terms of its interactions with autoimmune mechanisms.

Ultrasonic flow ratio measured immediately after successful rotational atherectomy with stent implantation predicts major adverse cardiovascular events.

Introduction: The potential role of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) and ultrasonic flow ratio (UFR) in predicting adverse outcomes in patients with successful rotational atherectomy (RA) and stent placement remains to be defined.

Methods: A total of 68 patients with highly calcific lesions, who underwent both QFR and UFR measurements after PCI with both RA and stenting, were enrolled. The major adverse coronary events (MACE) of 62 patients who completed 12-month follow-up were analyzed.

Intravascular lithotripsy vs. rotational atherectomy on coronary microcirculation: a retrospective multicenter propensity-matched multicenter study.

Background: Coronary microvascular dysfunction (CMD) predicts poor prognosis in patients with coronary artery disease (CAD). However, the impact of intravascular lithotripsy (IVL) on CMD remains unclear, and no studies have directly compared IVL and rotational atherectomy (RA) in the context of CMD.

Objective: This study aimed to evaluate CMD, as indicated by angiographic microvascular resistance (AMR), in patients undergoing IVL- or RA-assisted PCI for heavily calcified coronary lesions.

From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death and mitochondrial dysfunction, particularly ferroptosis and mitochondrial injury. Recent studies have indicated that ferroptosis and mitochondrial damage play crucial roles in the onset and progression of DCM, though their precise regulatory mechanisms remain unclear. Of particular interest is the interaction between ferroptosis and mitochondrial damage, as well as their synergistic effects, which are not fully understood.

MiR-371b-5p reduces osteosarcoma cell migration and proliferation to induce apoptosis by targeting FUT4.

In our previous study (PMID: 34671604), we found that miR-317b-5b not only exerted anti-tumor effect, but also downregulated FUT4 expression in human myeloma cell line 143B. This study aims to investigate the biological function of miR-371b-5p in osteosarcoma progression and the role of FUT4 in this process. For investigations, the human osteosarcoma cell lines (SaOS2, 143B, KHOS and U2OS) as well as the human osteoblast cell line (hFOB1.

Prognostic value of angiography-derived microcirculatory resistance in patients undergoing rotational atherectomy- a multi-center study.

Background: Rotational atherectomy (RA) is predominantly performed to treat severely calcified lesions in patients with coronary atherosclerotic heart disease (CAD). Studies focusing on the assessment of postoperative coronary microvascular dysfunction (CMD) after RA and related prognosis are scarce.

Aims: We investigated the predictive risks of microvascular dysfunction and postoperative major adverse cardiovascular events (MACE) in patients after RA.

Music of Different Tones Maintains Intestinal Immunity by Regulating the Intestinal Barrier and Intestinal Microbiota.

Music as an environmental factor can maintain intestinal health in animals, but it is unclear whether this effect is influenced by the tones of the music. In this study, 100 Kunming white mice were randomly divided into control group (C group) with no music, and three music groups were exposed to Mozart K.448 in D, A and G tone (D group, A group and G group), respectively.

The potential value of microRNA-409-5p-mediated negative regulation of USP7 in the diagnosis and treatment of acute myocardial infarction.

Purpose: This study aimed to explore the effects of ubiquitin-specific peptidase 7 (USP7) on acute myocardial infarction (AMI) and the negative regulation of USP7 by microRNA-409-5p (miR-409-5p).

Methods: Clinical data were collected from patients admitted to the Cardiology Department of Yan'an Hospital of Kunming City between July 2020 and July 2021. The participants included patients with AMI (AMI; n = 30), stable angina pectoris (SAP; n = 30), and chest pain syndrome (CPS; n = 30) and healthy controls (n = 30).

Singlet-Oxygen-Driven Cooperative Photocatalytic Coupling of Biomass Valorization and Hydrogen Peroxide Production Using Covalent Organic Frameworks.

Traditional HO photocatalysis primarily depends on photoexcited electrons and holes to drive oxygen reduction and water oxidation, respectively. However, singlet oxygen (O), often underappreciated, plays a pivotal role in HO production. Meanwhile, photocatalytic biomass conversion has attracted attention, yet studies combining HO synthesis with biomass valorization remain rare and typically yield low-value products.

[Kinematics and plantar pressure analysis of human body during sit-to-stand in adults].

Sit-to-stand is an indispensable functional activity in human daily life, which requires high muscle strength, not only to control the lower limbs, but also to ensure the stable ascension of the trunk. This paper describes in detail the trajectory and speed of the joints through the human sit-to-stand test, analyzes the change rule of the angle of the joints, the angular velocity and the position of the center of mass in the human sit-to-stand, and records in detail the change of the plantar pressure of the subjects in this process. Through the study on joint motion and plantar pressure changes in the process of sit-to-stand, this paper summarizes the kinematics of human body in this process, aiming to provide a basis through the results of this paper for the design of human sit-to-stand assistive devices, which may be used in the future to analyze the sit-to-stand state of patients with lower limb disorders, and carry out the corresponding treatment and rehabilitation training.

Expedited conveyance of out-of-hospital-cardiac arrest patients with STEMI and shockable rhythms to Cardiac Arrest Centres - A feasibility pilot study of the British Cardiovascular Intervention Society conveyance algorithm.

Background And Aims: Guidelines suggest non-traumatic out-of-hospital cardiac arrest (OHCA) be conveyed to cardiac arrest centres (CAC). We hypothesised that (a) a pre-hospital conveyance algorithm based on initial presenting rhythm following OHCA is feasible and (b) that would demonstrate survival advantage.

Methods: This observational pilot study included all consecutive patients with OHCA from suspected cardiac aetiology from the county of Essex, United Kingdom from April 2022-April 2023.

An automated method of streamlining waiting list by clinical risk fast-tracking for patients awaiting TAVR: SWIFT TAVR algorithm.

Introduction: Transcatheter aortic valve replacement (TAVR) is increasingly in demand for treating severe aortic stenosis in a variety of surgical risk profiles. This means increasing wait times and elevated morbidity and mortality on the waitlist. To address this, we developed the SWIFT TAVR algorithm to prioritize patients based on clinical risk and reduce wait times.

Improving primary healthcare quality in China through training needs analysis.

The diagnosis and treatment capability levels of healthcare professionals directly affect the overall quality of medical services. Enhancing these capability levels requires strengthening the professional skill training of healthcare workers, especially those in primary care settings in economically underdeveloped areas. To understand the actual needs for professional skill training among primary healthcare workers, thereby providing data support for targeted training initiatives.

Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer's disease.

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder affecting millions of people worldwide, with no effective treatment currently available. In recent decades, various traditional Chinese medicines (TCMs) and their active ingredients have shown the potential to attenuate the pathogenesis of AD in cellular and animal models. However, the effects of TCM formulas, which are typically administered in practice, have been less studied.

Characteristics of volatile organic compounds under different operating conditions in a petrochemical industrial zone and their effects on ozone formation.

The petrochemical industry is one of the major sources of volatile organic compounds (VOCs) emissions. Current research on VOC pollution characteristics in petrochemical industrial areas predominantly focuses on normal operating conditions, overlooking VOC pollution during overhaul. This study comparatively analyzes the pollution characteristics of VOCs, the potential sensitivity of O formation, and the pollution sources during normal production (PI), partial instrument overhaul (PII), and large-scale instrument overhaul (PIII) at a typical petrochemical industrial enterprise A (PEA) in Northwest China.

Circulating microRNA-409-5p and USP7 are associated with left ventricular remodeling in patients with acute myocardial infarction.

Background: Our previous study demonstrated that microRNA-409-5p (miR-409-5p) and its target ubiquitin-specific protease 7 (USP7) were involved in hypoxia-induced cardiomyocyte injury and ischemic left ventricular remodeling (LVR) in rats. This study aimed to probe into the relationship between plasma miR-409-5p and USP7 levels and LVR and dysfunction in patients with acute myocardial infarction (AMI).

Methods: Sixty patients with acute myocardial infarction (AMI) and 60 cases with chronic coronary syndrome (CCS) were enrolled.

Intermittent cold stimulation acclimates broilers to acute cold stress by affecting cardiac lipid metabolism.

Objective: This study aimed to investigate whether intermittent cold stimulation can induce adaptation in broilers to acute cold stress (ACS) by regulating the lipid metabolism of hearts.

Methods: CS0 were kept at normal rearing temperature, while CS3 and CS5 were exposed to 3°C for 3 and 5 hours, respectively, on alternate days lower than CS0 from 15d to 35d. On 50d, broilers in three groups were exposed to ACS at 10°C for 12 hours (Y12).

WITHDRAWN: Photothermally reinforced chemodynamic therapy in the treatment of osteosarcoma by polydopamine-modified, copper peroxide loaded ZIF8 nanoparticles.

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