Sensitivity analysis for time-to-event data accounting for intra-individual variability in time-varying covariates with missing data.

The Delta-Adjusted (DA) approach in multiple imputation (MI) is applied under several key assumptions in the Cox hazard model, where two time-dependent covariates have missing observations. Missingness in these covariates is assumed to be not missing at random (NMAR) and is modeled through delta adjustments, with different delta values specified to capture deviations from the missing at random (MAR) assumption. Within the MI framework, missing values are imputed under various plausible missingness scenarios while preserving the relationship between time-dependent covariates and the event-time outcome.

Analysis of yield stability and genotype-environment interaction for open-pollinated tomato varieties in the Kashmir Himalaya using the AMMI model.

This study investigates the yield stability and adaptability of sixteen open-pollinated tomato (Solanum lycopersicum Mill.) genotypes across multiple environments in the Kashmir Valley, employing Additive Main Effect and Multiplicative Interaction (AMMI) analysis to examine genotype-environment interactions (GEI). A Randomized Complete Block Design (RCBD) with three replications was implemented at six locations over two years, representing the region's diverse environmental conditions.

RRM2B deficiency causes dATP and dGTP depletion through enhanced degradation and slower synthesis.

Mitochondrial DNA (mtDNA) replication requires a steady supply of deoxyribonucleotides (dNTPs), synthesized de novo by ribonucleotide reductase (RNR). In nondividing cells, RNR consists of RRM1 and RRM2B subunits. Mutations in cause mtDNA depletion syndrome, linked to muscle weakness, neurological decline, and early mortality.

Isolation and characterization of novel bacterial strain from sewage sludge and exploring its potential for hydrogen production.

Hydrogen (H) energy has garnered significant attention due to its numerous advantages. Nonetheless, for future commercialization, it is imperative to screen and identify strains with enhanced H-producing capacities. In order to attain a high and consistent production performance, the conversion of biomass sources into H requires careful selection of the most appropriate H-producing bacteria.

Bloodstream infections in cancer patients in central India: pathogens and trends of antimicrobial resistance over a 5-year period.

Bloodstream infection (BSI) is a common complication with a high fatality rate in cancer patients. There are notable variations in the epidemiology of BSI over time and among different countries. Infections due to multidrug-resistant organisms (MDROs) such as extended-spectrum beta-lactamases (ESBLs) and carbapenem-resistant (CRE) are increasing.

Computational study of the performance of a solar dryer for improvement in the shelf life of the food materials.

In this study, the thermal and drying characteristics of a thin layer food sample were investigated. An indirect type, simple, efficient, and economically feasible solar dryer was fabricated and used for food preservation. However, a dynamic model of a fabricated solar dryer was also presented to gain a better insight into the drying and thermal actions.

The impact of informality and institutional quality on environmental footprint: The case of emerging economies in a comparative approach.

The endeavor to implement the 2030 Agenda of national and international stakeholders became increasingly impetuous, considering the wide range of uncertainties and risks. The new humans-centered development model built on the prominence of environmental and social values seeks to reinforce communities' resilience and mitigate environmental risks, leaving no one behind. For this to happen, solid and effective institutions, the right environmental policies, and a safe statutory labor framework are the sine qua non.

An Overview of Pulses Production in India: Retrospect and Prospects of the Future Food with an Application of Hybrid Models.

Forecasts are valuable to countries to make informed business decisions and develop data-driven strategies. The production of pulses is an integral part of agricultural diversification initiatives because it offers promising economic opportunities to reduce rural poverty and unemployment in developing countries. Pulses are the cheapest source of protein needed for human health.

dNTP concentrations do not increase in mammalian cells in response to DNA damage.

A recent publication reported a uniform ∼5- to 6-fold increase in dNTP pools 30 min after exposure to ionizing radiation. Das et al. were not able to reproduce these results.

Towards enhancement of fungal hydrolytic enzyme cocktail using waste algal biomass of Oscillatoria obscura and enzyme stability investigation under the influence of iron oxide nanoparticles.

Development of low-cost and economic cellulase production is among the key challenges due to its broad industrial applications. One of the main topics of research pertaining to sustainable biomass waste based biorefinaries is the development of economic cellulase production strategies. The main cause of the increase in cellulase production costs is the use of commercial substrates; as a result, the cost of any cellulase-based bioprocess can be decreased by employing a productive, low-cost substrate.

Machine learning and automatic ARIMA/Prophet models-based forecasting of COVID-19: methodology, evaluation, and case study in SAARC countries.

Machine learning (ML) has proved to be a prominent study field while solving complex real-world problems. The whole globe has suffered and continues suffering from Coronavirus disease 2019 (COVID-19), and its projections need to be forecasted. In this article, we propose and derive an autoregressive modeling framework based on ML and statistical methods to predict confirmed cases of COVID-19 in the South Asian Association for Regional Cooperation (SAARC) countries.

A scoping study of the medication therapy related pharmacist services in the Western Pacific Region.

Objectives: To identify the preferred terminologies, nature of services, perceived benefits and barriers to medication therapy-related pharmacist services in the Western Pacific region to facilitate the development of a framework for medication therapy management.

Method: A survey was completed by hospital and community pharmacists purposively selected by the national pharmacist associations.

Key Findings: Pharmaceutical care was the preferred term with services predominantly related to medication safety and public health.

Fungal Endophytes: an Accessible Source of Bioactive Compounds with Potential Anticancer Activity.

Endophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host plants without showing any immediate negative effects on them. Among numerous natural alternative sources, fungal endophytes produce a wide range of structurally diverse bioactive metabolites including anticancer compounds. Considering the production of bioactive compounds in low quantity, genetic and physicochemical modification of the fungal endophytes is performed for the enhanced production of bioactive compounds.

Study on Blood Serum Levels of Heavy and Trace Metals in Chronic Non-Healing Wounds.

Wound healing is a complex, highly regulated process that is important in sustaining the skin barrier function. The etiologic relation of specific metals is not adequately described for chronic non-healing wounds. The aim of this study was to estimate heavy and trace metals in chronic non-healing wound and their association with wound healing The levels of zinc, selenium, copper, magnesium, chromium, cadmium, iron, and lead were estimated in serum of chronic non-healing wound patients using atomic absorption spectrophotometry.

A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans.

Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals. We express the modern human and the ancestral enzymes and show that whereas the activity and stability are unaffected by the amino acid substitution, the ancestral enzyme produces more reactive oxygen species and increases cellular levels of transcripts encoding cytokines.

State of the art in total pulse production in major states of India using ARIMA techniques.

Pulses are staple protein-rich food for Indian vegetarians, and India is one of the largest producers in the world. The present investigation is an attempt to study the trend in the production of total pulses in India using the autoregressive integrated moving average (ARIMA) method. For stochastic trend estimation, yearly data were used for the period from 1961 to 2019.

Correction of amygdalar dysfunction in a rat model of fragile X syndrome.

Fragile X syndrome (FXS), a commonly inherited form of autism and intellectual disability, is associated with emotional symptoms that implicate dysfunction of the amygdala. However, current understanding of the pathogenesis of the disease is based primarily on studies in the hippocampus and neocortex, where FXS defects have been corrected by inhibiting group I metabotropic glutamate receptors (mGluRs). Here, we observe that activation, rather than inhibition, of mGluRs in the basolateral amygdala reverses impairments in a rat model of FXS.

Plant associated fungal endophytes as a source of natural bioactive compounds.

Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds. Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds.

Integrated process approach for degradation of p-cresol pollutant under photocatalytic reactor using activated carbon/TiO nanocomposite: application in wastewater treatment.

Over the years, biodegradation has been an effective technique for waste water treatment; however, it has its own limitations. In order to achieve a higher degradation efficacy, integrated processes are being focus in this area. Therefore, the present study is targeted towards the coupling of biodegradation and photocatalytic degradation of p-cresol.

Technological advances for improving fungal cellulase production from fruit wastes for bioenergy application: A review.

Fruit wastes can be imperative to elevate economical biomass to biofuels production process at pilot scale. Because of the renewable features, huge availability, having low lignin content organic nature and low cost; these wastes can be of much interest for cellulase enzyme production. This review provides recent advances on the fungal cellulase production using fruit wastes as a potential substrate.

Immunogenicity and safety of two quadrivalent influenza vaccines in healthy adult and elderly participants in India - A phase III, active-controlled, randomized clinical study.

Background: This study was conducted to compare the immunogenicity and safety profile of two quadrivalent influenza vaccines (QIVs) in healthy adults (18-60 years) and elderly (>61 years) participants.

Method: This phase III study was conducted from March 2018 to April 2018 across 12 sites in India. In this randomized, observer-blind, active-controlled study, 480 participants were randomized to receive a single dose of test vaccine (subunit, inactivated influenza vaccine; Influvac® Tetra, Abbott) (n = 240) or reference vaccine (split virion, inactivated influenza vaccine; VaxiFlu-4, Zydus Cadilla Healthcare) (n = 240).

Nano-fibrous scaffold with curcumin for anti-scar wound healing.

Open deep cuts and wounds often take a long time to heal and may cause infection and scar formation. A simple biomimetic electrospun nano-fibrous antimicrobial dressing material loaded with dual anti-oxidants has been developed to address this problem. A composite nano-fibrous material (PVP-Ce-Cur NF) comprising polyvinyl pyrrolidone (PVP), cerium nitrate hexahydrate (Ce(NO)·6HO) and curcumin was developed using the electrospinning technique.