A Pilot Study of the Combination of 5-Azacitidine and All-trans Retinoic Acid in Biochemically Recurrent Prostate Cancer.

Purpose: Biochemical recurrence (BCR) after definitive local therapy remains a major clinical challenge in prostate cancer (PCa), with heterogeneous disease trajectories and few established strategies to delay further progression without prolonged androgen deprivation. This pilot study evaluated the combination of 5-azacitidine (AZA) and all-trans retinoic acid (ATRA) to induce tumor dormancy and delay clinical progression in patients with BCR.

Experimental Design: In a prospective, open-label, randomized, single-institution pilot trial, patients with BCR of PCa and no recent hormonal or definitive therapy received low-dose AZA and sequential ATRA.

Characterization and predictive modelling of quasi-saturated hydraulic conductivity across land use systems in the Northwest Himalayas.

This study investigated the variation in soil hydrological properties-saturated water-holding capacity (SWHC), field capacity (FC), total porosity (TP), and saturated hydraulic conductivity (Ks)-across different land use systems in the Semalta watershed of the north Himalayan foothills. Soil samples were collected from four land use types (agriculture, barren land, deodar forest, and oak forest) at two depths (0-15 cm and 15-30 cm). Key parameters were measured using mini-disk infiltrometers and standard laboratory techniques.

Optimization of pore geometry and size of scaffold type structures for cell culture.

Biomedical scaffolds are essential for tissue engineering as they provide a structural framework for tissue regeneration. This study investigates the optimization of polylactic acid scaffolds' pore geometry, fabricated using fused deposition modeling, to enhance tissue regeneration. Computational fluid dynamics analysis determined the impact of side length and wall thickness on permeability and pressure drop, while mechanical testing assessed induced stress.

Harnessing the Power of AI in Cell and Genetic Engineering.

The synergistic integration of Artificial Intelligence (AI) techniques with bioinformatics, statistics, and biotechnology has ushered in a transformative era in the realms of cell and genetic engineering. This convergence represents a powerful alliance, combining the computational prowess of AI with the wealth of biological information harnessed through bioinformatics and statistical methodologies. The collaborative impact of these disciplines has redefined our approach to understanding, manipulating, and optimizing complex biological systems.

Change in cervical posture after maxillary protraction with facemask therapy: A retrospective study.

Introduction: The aim of this study was to investigate the effects of rapid maxillary expansion (RME) and facemask therapy on cervical vertebral column in growing patients with skeletal class III malocclusion.

Material And Methods: The pre- (T1) and post-treatment (T2) cephalometric records of eighteen subjects (10 girls, 8 boys; mean age, 9.47 ± 1.

Optimized breast cancer diagnosis using self-adaptive quantum metaheuristic feature selection.

Breast cancer is a leading cause of mortality among women and is increasing rapidly around the world. For early diagnosis of breast cancer, precise classification, and finding the best subset for cancer identification, evolutionary-based feature selection methods play a vital role in effective treatment. Previous studies have shown that existing evolutionary methods are complicated in correctly differentiating BC disease subtypes with high consistency, which seriously affects the performance of classification methods.

Virtual nurse support to enhance antipsychotic adherence in schizophrenia: A South African perspective.

Background: Patients with schizophrenia rely on antipsychotic medication, with adherence being critical for symptom management. Poor adherence leads to relapse, disability and increased healthcare costs.

Aim: This study investigated the impact on antipsychotic adherence among schizophrenia patients on the introduction of an intervention utilising a psychiatric nurse as a virtual treatment buddy.

Proximal Radioulnar Synostosis Post-radial Head Fracture: Surgical Excision and Anconeus Muscle Flap Interposition for Functional Restoration.

Adult proximal radioulnar synostosis is a rare complication where its manifestation is due to either post-surgery or post-traumatic effect causing limitation in the function of the forearm especially in supination and pronation. Most common occurrences of synostosis over the forearm region can be divided based on anatomical location, which involves the distal third, middle third, and proximal third forearm region. We report the case of a 42-year-old woman who developed proximal radioulnar synostosis following a conservatively treated radial head fracture 18 months earlier.

Spatial Variation and Adaptive Responses of Tall-Type Field Peas (Pisum sativum L.) Across Indian Subcontinent.

Understanding crop performance across diverse agro-ecologies is crucial for developing region-specific breeding strategies. This multi-location study examined the impact of diverse environments on crop eco-phenology and genotype-by-environment interactions (GEI) of tall-type field pea breeding lines. Empirical methods were employed to identify strategic locations that support higher yields and unique genotypic traits.

Adaptive responses of large-seeded lentils across diverse Indian climates.

A comprehensive understanding of crop responses to diverse environments is essential for designing efficient breeding programs. Currently, such insights are lacking for large-seeded lentils under Indian climatic conditions. Given that, this study aimed to assess the impacts of diverse climatic conditions on phenological developments and yield of large-seeded lentils.

Comparison of Peri-Oral and Masticatory Muscle Activity between Repaired Unilateral Cleft Lip and Palate and Non-Cleft Individuals - A Systematic Review.

Surgical intervention in patients with repaired unilateral cleft lip and palate (UCLP) leads to altered muscular activity and hinders the normal growth of the maxilla. To compare the activity of superior orbicularis oris and masticatory muscles between repaired unilateral cleft lip and palate and non-cleft individuals. A literature search was carried out on MEDLINE/PubMed, Cochrane Library, Science Direct, Semantic Scholar, and Google Scholar databases upto January 2024 resulting in 1320 studies.

Time-Reversal Symmetry Breaking Superconductivity in HfRhGe: A Noncentrosymmetric Weyl Semimetal.

Weyl semimetals are a novel class of topological materials with unique electronic structures and distinct properties. HfRhGe stands out as a noncentrosymmetric Weyl semimetal with unconventional superconducting characteristics. Using muon-spin rotation and relaxation (µSR) spectroscopy and thermodynamic measurements, a fully gapped superconducting state is identified in HfRhGe that breaks time-reversal symmetry at the superconducting transition.

Supracardiac type of total anomalous pulmonary venous connection: Diagnosis and demonstration by multidetector CT angiography.

Pulmonary venous developmental anomalies have historically been evaluated using echocardiography and catheter-based angiography. In recent years, however, multidetector CT angiography (MDCTA) and MR angiography have become increasingly important tools for detailed characterization of these anomalies. This case report provides an in-depth review of the radiologic findings in a 15-year-old patient diagnosed with the supracardiac type of Total Anomalous Pulmonary Venous Connection (TAPVC).

Treatment of pulp and paper mill effluent through combined aerobic and anaerobic suspended fixed-bed bioreactor.

This study explored using ultrafiltration (UF) membranes to treat pulp and paper mill wastewater, implementing a novel Taguchi experimental design to optimize operating conditions for pollutant removal and minimal membrane fouling. Researchers examined four factors: pH, temperature, transmembrane pressure, and volume reduction factor (VRF), each at three levels. Optimal conditions (pH 10, 25°C, 6 bar, VRF 3) led to a 35% reduction in flux due to fouling and high pollutant rejections: total hardness (83%), sulfate (97%), spectral absorption coefficient (SAC254) (95%), and chemical oxygen demand (COD) (89%).

Solar water splitting for hydrogen production using Zn electrodes: a green and sustainable approach.

The global transition towards clean and sustainable energy sources has led to an increasing interest in green hydrogen production. The present work focuses on the development and assessment of a solar-assisted green hydrogen production system. The basic objective of this work is to investigate the influence of solar radiation to drive the electrolysis process for green hydrogen production.

Prognostic Significance of Lymph Node Ratio in Predicting the Outcome of Oral Squamous Cell Carcinoma - A Retrospective Study.

Introduction: The lymph node status is a very important prognostic factor in head-and-neck cancer. The presence of metastatic lymph nodes will reduce the overall survival by 50%. Lymph node ratio (LNR) is defined as the ratio of the number of positive lymph nodes to the total number of lymph nodes dissected.

Antioxidant activities, dietary nutrients, and yield potential of bitter gourd ( L.) lines in diverse growing environments.

The biotic and abiotic stresses cause a significant decline in the yield and fruit quality traits, including antioxidants and minerals, of bitter gourd when grown in open fields. Protected cultivation technology has emerged to minimize such stresses. We investigated the effect of diverse environments (hi-tech greenhouse, naturally ventilated polyhouse, insect-proof net-house, and open field) and breeding lines on earliness, yield potential, antioxidant activities, and dietary nutrients.

MANCR lncRNA Modulates Cell-Cycle Progression and Metastasis by Cis-Regulation of Nuclear .

A significant number of the genetic alterations observed in cancer patients lie within nonprotein-coding segments of the genome, including regions coding for long noncoding RNAs (lncRNAs). LncRNAs display aberrant expression in breast cancer (BrCa), but the functional implications of this altered expression remain to be elucidated. By performing transcriptome screen in a triple negative BrCa (TNBC) isogenic 2D and 3D spheroid model, we observed aberrant expression of >1000 lncRNAs during BrCa progression.