Emerging trends and global collaboration in Paclitaxel resistance research for breast cancer: a comprehensive bibliometric study.

Paclitaxel, a compound that targets microtubules in cancer cells and inhibits mitosis, has been used as a first-line treatment for recurrent or metastatic breast cancer for over three decades. Research into paclitaxel resistance has yielded thousands of articles. However, this body of research has not been analyzed systematically and quantitatively.

Curcumin suppresses metastasis of triple-negative breast cancer cells by modulating EMT signaling pathways: An integrated study of bioinformatics analysis.

This study aimed to use bioinformatics approaches for predicting the anticancer mechanisms of curcumin on triple-negative breast cancer (TNBC) and to verify these predictions through in vitro experiments. Initially, the Cell Counting Kit-8 (CCK8) assay was employed to rigorously investigate the influence of curcumin on the proliferative capacity of TNBC cells. Subsequently, flow cytometry was employed to meticulously assess the impact of curcumin on cellular apoptosis and the cell cycle regulation.